Identifying biomarkers specific to bone metastases in castrate-resistant prostate cancer.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 5092-5092
Author(s):  
Maahum Ali Haider ◽  
Colm Morrissey ◽  
Ilsa Coleman ◽  
Xiaotun Zhang ◽  
Lisha Brown ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastases ◽  
Castrate Resistant Prostate Cancer ◽  
Castrate Resistant

scholarly journals Current perspectives on bone metastases in castrate-resistant prostate cancer

2018 ◽  
Vol 37 (1) ◽  
pp. 189-196 ◽  
Author(s):  
Christopher Logothetis ◽  
Michael J. Morris ◽  
Robert Den ◽  
Robert E. Coleman
Keyword(s):  
Prostate Cancer ◽  
Bone Metastases ◽  
Castrate Resistant Prostate Cancer ◽  
Castrate Resistant

scholarly journals Bone-Targeted Therapies in Metastatic Castration-Resistant Prostate Cancer: Evolving Paradigms

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Joelle El-Amm ◽  
Ashley Freeman ◽  
Nihar Patel ◽  
Jeanny B. Aragon-Ching
Keyword(s):  
Prostate Cancer ◽  
Bone Metastases ◽  
Kinase Inhibitors ◽  
Targeted Agents ◽  
Pain Palliation ◽  
Castration Resistant Prostate Cancer ◽  
Humanized Monoclonal Antibody ◽  
Castrate Resistant Prostate Cancer ◽  
Castrate Resistant ◽  
Overall Survival Benefit

Majority of patients with metastatic castrate resistant prostate cancer (mCRPC) develop bone metastases which results in significant morbidity and mortality as a result of skeletal-related events (SREs). Several bone-targeted agents are either in clinical use or in development for prevention of SREs. Bisphosphonates were the first class of drugs investigated for prevention of SREs and zoledronic acid is the only bisphosphonate that is FDA-approved for this indication. Another bone-targeted agent is denosumab which is a fully humanized monoclonal antibody that binds to the RANK-L thereby inhibiting RANK-L mediated bone resorption. While several radiopharmaceuticals were approved for pain palliation in mCRPC including strontium and samarium, alpharadin is the first radiopharmaceutical to show significant overall survival benefit. Contemporary therapeutic options including enzalutamide and abiraterone have effects on pain palliation and SREs as well. Other novel bone-targeted agents are currently in development, including the receptor tyrosine kinase inhibitors cabozantinib and dasatinib. Emerging therapeutics in mCRPC has resulted in great strides in preventing one of the most significant sources of complications of bone metastases.

SU-D-303-01: Spatial Distribution of Bone Metastases In Metastatic Castrate-Resistant Prostate Cancer

2015 ◽  
Vol 42 (6) ◽  
pp. 3214-3215 ◽  
Author(s):  
T Perk ◽  
T Bradshaw ◽  
S Harmon ◽  
S Perlman ◽  
G Liu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Spatial Distribution ◽  
Bone Metastases ◽  
Castrate Resistant Prostate Cancer ◽  
Castrate Resistant
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