A first-in-human dose-escalation study of the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of oral 2-hydroxyoleic acid (2-OHOA) in adult patients (pt) with advanced solid tumors including grade III/IV glioblastoma multiforme (GBM).

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 2513-2513 ◽  
Author(s):  
Desamparados Roda ◽  
Yvette Drew ◽  
Analia Azaro ◽  
Alan David Smith ◽  
Alastair Greystoke ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Solid Tumors ◽  
Dose Escalation ◽  
Adult Patients ◽  
Advanced Solid Tumors ◽  
Dose Escalation Study ◽  
Human Dose ◽  
Grade Iii

scholarly journals Phase I, First‐in‐Human, Dose‐Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Vorolanib in Patients with Advanced Solid Tumors

2018 ◽  
Vol 24 (4) ◽  
pp. 455 ◽  
Author(s):  
Johanna C. Bendell ◽  
Manish R. Patel ◽  
Kathleen N. Moore ◽  
Cynthia C. Chua ◽  
Hendrik‐Tobias Arkenau ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Dose Escalation ◽  
Advanced Solid Tumors ◽  
Dose Escalation Study ◽  
Human Dose

First-in-human dose escalation study of oral ONC201 in advanced solid tumors.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. TPS2623-TPS2623 ◽  
Author(s):  
Mark N. Stein ◽  
Tina M. Mayer ◽  
Rebecca Anne Moss ◽  
Ann W. Silk ◽  
Nancy Chan ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Dose Escalation ◽  
Advanced Solid Tumors ◽  
Dose Escalation Study ◽  
Human Dose

Abstract C137: First-in-human dose escalation study of oral ONC201 in advanced solid tumors

2015 ◽  
Author(s):  
Mark N. Stein ◽  
Rebecca Moss ◽  
Tina Mayer ◽  
Ann W. Silk ◽  
Nancy Chan ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Dose Escalation ◽  
Advanced Solid Tumors ◽  
Dose Escalation Study ◽  
Human Dose

scholarly journals A Phase I, Multicenter, Open-Label, First-in-Human, Dose-Escalation Study of the Oral Smoothened Inhibitor Sonidegib (LDE225) in Patients with Advanced Solid Tumors

2014 ◽  
Vol 20 (7) ◽  
pp. 1900-1909 ◽  
Author(s):  
Jordi Rodon ◽  
Hussein A. Tawbi ◽  
Anne L. Thomas ◽  
Ronald G. Stoller ◽  
Christian P. Turtschi ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Dose Escalation ◽  
Advanced Solid Tumors ◽  
Open Label ◽  
Dose Escalation Study ◽  
Human Dose

A phase 1 dose-escalation study of BBI503, a first-in-class cancer stemness kinase inhibitor in adult patients with advanced solid tumors.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 2527-2527 ◽  
Author(s):  
Scott Andrew Laurie ◽  
Derek J. Jonker ◽  
William Jeffery Edenfield ◽  
Joe Stephenson ◽  
Deborah Keller ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Dose Escalation ◽  
Kinase Inhibitor ◽  
Phase 1 ◽  
Adult Patients ◽  
Advanced Solid Tumors ◽  
Cancer Stemness ◽  
Dose Escalation Study

A first-in-human dose escalation study of PEGylated recombinant human IL-10 (AM0010) in advanced solid tumors.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 3017-3017 ◽  
Author(s):  
Jeffrey R. Infante ◽  
Aung Naing ◽  
Kyriakos P. Papadopoulos ◽  
Karen A. Autio ◽  
Patrick Alexander Ott ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Dose Escalation ◽  
Advanced Solid Tumors ◽  
Dose Escalation Study ◽  
Human Dose

scholarly journals A first-in-human dose-escalation study of ME-143, a second generation NADH oxidase inhibitor, in patients with advanced solid tumors

2013 ◽  
Vol 32 (1) ◽  
pp. 87-93 ◽  
Author(s):  
Shubham Pant ◽  
Howard A. Burris ◽  
Kathleen Moore ◽  
Johanna C. Bendell ◽  
Carla Kurkjian ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Dose Escalation ◽  
Second Generation ◽  
Nadh Oxidase ◽  
Oxidase Inhibitor ◽  
Advanced Solid Tumors ◽  
Dose Escalation Study ◽  
Human Dose
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