Mechanisms of Action of Chemical Carcinogens and Their Role in Structure–Activity Relationships (SAR) Analysis and Risk Assessment

Understanding the structure–activity relationships and mechanisms of action of membranolytic anticancer peptides could help them advance to therapeutic success.

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Formation of Categories from Structure−Activity Relationships To Allow Read-Across for Risk Assessment: Toxicity of α,β-Unsaturated Carbonyl Compounds

Chemical Research in Toxicology ◽

10.1021/tx8002438 ◽

2008 ◽

Vol 21 (12) ◽

pp. 2300-2312 ◽

Cited By ~ 50

Author(s):

Yana K. Koleva ◽

Judith C. Madden ◽

Mark T. D. Cronin

Keyword(s):

Risk Assessment ◽

Carbonyl Compounds ◽

Structure Activity Relationships ◽

Structure Activity

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Positive and Negative Allosteric Modulators ofN-Methyl-d-aspartate (NMDA) Receptors: Structure–Activity Relationships and Mechanisms of Action

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b01640 ◽

2018 ◽

Vol 62 (1) ◽

pp. 3-23 ◽

Cited By ~ 17

Author(s):

Erica S. Burnell ◽

Mark Irvine ◽

Guangyu Fang ◽

Kiran Sapkota ◽

David E. Jane ◽

...

Keyword(s):

Nmda Receptors ◽

Mechanisms Of Action ◽

Allosteric Modulators ◽

Structure Activity Relationships ◽

Structure Activity

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Risk assessment for mutagenic and carcinogenic activities of α,β-unsaturated carbonyl compounds by a screening strategy based on structure-activity relationships

Toxicology in Vitro ◽

10.1016/0887-2333(94)90048-5 ◽

1994 ◽

Vol 8 (4) ◽

pp. 707-710 ◽

Cited By ~ 3

Author(s):

E. Eder ◽

C. Hoffman ◽

C. Deininger ◽

S. Scheckenbach

Keyword(s):

Risk Assessment ◽

Carbonyl Compounds ◽

Screening Strategy ◽

Structure Activity Relationships ◽

Structure Activity

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Ferrocene-containing hybrids as potential anticancer agents: Current developments, mechanisms of action and structure-activity relationships

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.112109 ◽

2020 ◽

Vol 190 ◽

pp. 112109 ◽

Cited By ~ 11

Author(s):

Ruo Wang ◽

Huahong Chen ◽

Weitao Yan ◽

Mingwen Zheng ◽

Tesen Zhang ◽

...

Keyword(s):

Anticancer Agents ◽

Mechanisms Of Action ◽

Structure Activity Relationships ◽

Structure Activity

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Quantitative Structure-Activity Relationships and Possible Mechanisms of Action of Bispyridinium Oximes as Antidotes Against Pinacolyl Methylphosphonofluoridate

Toxicological Sciences ◽

10.1093/toxsci/3.4.271 ◽

1983 ◽

Vol 3 (4) ◽

pp. 271-277

Author(s):

CHINC-TANG SU ◽

CHIA-PIN TANG ◽

CHONG MA ◽

YU-SHAN SHIH ◽

CHONG-YEAN LIU ◽

...

Keyword(s):

Mechanisms Of Action ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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