The Role of Xanthine Oxidase in Disease

1996 ◽  
pp. 33-44
Author(s):  
C Stevens ◽  
T Sahinoglu ◽  
B Bhatt ◽  
N Ali ◽  
D Blake
Keyword(s):  
Xanthine Oxidase

scholarly journals The role of superoxide in xanthine oxidase-induced autooxidation of linoleic acid.

1982 ◽  
Vol 257 (14) ◽  
pp. 8343-8347
Author(s):  
M J Thomas ◽  
K S Mehl ◽  
W A Pryor
Keyword(s):  
Linoleic Acid ◽  
Xanthine Oxidase

scholarly journals The Role of Molybdenum in Xanthine Oxidase and Related Enzymes

1969 ◽  
Vol 244 (10) ◽  
pp. 2658-2663 ◽  
Author(s):  
M P Coughlan ◽  
K V Rajagopalan ◽  
P Handler
Keyword(s):  
Xanthine Oxidase

scholarly journals Role of Xanthine Oxidase in the Reduction of Resazurin by Raw Milk

1961 ◽  
Vol 44 (3) ◽  
pp. 425-429 ◽  
Author(s):  
J.J.R. Campbell ◽  
Lynette B. Keur
Keyword(s):  
Xanthine Oxidase ◽  
Raw Milk

Biological Role of Xanthine Oxidase and Tetrazolium-Reductase Inhibitor

1973 ◽  
Vol 33 (3) ◽  
pp. 439-445 ◽  
Author(s):  
Rainer Fried ◽  
Lygia W. Fried ◽  
Donald R. Babin
Keyword(s):  
Xanthine Oxidase ◽  
Reductase Inhibitor ◽  
Biological Role

scholarly journals The Role of Xanthine Oxidase and Xanthine Dehydrogenase in Skin Ischemia

1994 ◽  
Vol 56 (2) ◽  
pp. 162-167 ◽  
Author(s):  
Riley Rees ◽  
Del Smith ◽  
Ti Dong Li ◽  
Belinda Cashmer ◽  
Warren Garner ◽  
...  
Keyword(s):  
Xanthine Oxidase ◽  
Xanthine Dehydrogenase

Histochemical localization and possible antibacterial role of xanthine oxidase in the bovine mammary gland

1988 ◽  
Vol 55 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Robert A. Collins ◽  
Keith R. Parsons ◽  
Terry R. Field ◽  
A. John Bramley
Keyword(s):  
Antibacterial Activity ◽  
Mammary Gland ◽  
Xanthine Oxidase ◽  
Histochemical Localization ◽  
Bovine Mammary Gland ◽  
Streptococcus Uberis ◽  
Antibacterial Assay ◽  
Secretory Tissue ◽  
Teat Canal

SummaryXanthine oxidase (XO) was demonstrated to be present in the teat canal and secretory tissue of the bovine mammary gland by histochemical techniques. Homogenates of these tissues were able to replace XO in an antibacterial assay with Streptococcus uberis. The action of XO on its substrate hypoxanthine was shown to provide an essential component for anti-streptococcal activity mediated by lactoperoxidase. A mechanism is proposed whereby the interaction of XO, lactoperoxidase and thiocyanate may provide antibacterial activity in the teat canal.

Free radicals in hypoxic rat diaphragm contractility: no role for xanthine oxidase

2001 ◽  
Vol 281 (6) ◽  
pp. L1402-L1412 ◽  
Author(s):  
Leo M. A. Heunks ◽  
Herwin A. Machiels ◽  
Ronney de Abreu ◽  
Xiao Ping Zhu ◽  
Henricus F. M. van der Heijden ◽  
...  
Keyword(s):  
Free Radicals ◽  
Xanthine Oxidase ◽  
Power Output ◽  
Harmful Effect ◽  
Force Generation ◽  
Muscle Performance ◽  
Rat Diaphragm ◽  
Shortening Velocity ◽  
Contraction Pattern

Recent evidence indicates that hypoxia enhances the generation of oxidants. Little is known about the role of free radicals in contractility of the rat diaphragm during hypoxia. We hypothesized that antioxidants improve contractility of the hypoxic rat diaphragm and that xanthine oxidase (XO) is an important source of free radicals in the hypoxic diaphragm. The effects of N-acetylcysteine (NAC; 18 mM), Tiron (10 mM), and the XO inhibitor allopurinol (250 μM) were studied on isometric and isotonic force generation during hypoxia (Po 2 ∼7 kPa). NAC and Tiron decreased maximal force generation, slowed the shortening velocity, and decreased the power output. Fatigue rate was decreased in the presence of either NAC or Tiron. Allopurinol did not alter the contractility or fatigability of the diaphragm. During hyperoxia (Po 2 ∼85 kPa), neither NAC nor allopurinol affected the contractility or fatigability of the diaphragm. Thus free radicals play a significant role in diaphragm contractility during hypoxia. Whether antioxidants exert a beneficial or harmful effect on muscle performance depends on the contraction pattern of the muscle. Free radicals generated by XO do not play a role in diaphragm contractility during either hypoxia or hyperoxia.

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