Clinically Relevant Drug Interactions with Systemic Antifungal Therapy

2005 ◽  
pp. 551-588
Keyword(s):  
Drug Interactions ◽  
Antifungal Therapy ◽  
Systemic Antifungal Therapy

Systemic Antifungal Therapy: New Options, New Challenges

2003 ◽  
Vol 23 (11) ◽  
pp. 1441-1462 ◽  
Author(s):  
Annie Wong-Beringer ◽  
Jane Kriengkauykiat
Keyword(s):  
Antifungal Therapy ◽  
New Challenges ◽  
Systemic Antifungal Therapy

Systemic antifungal therapy

2008 ◽  
pp. 186-197
Author(s):  
Joseph Taboada ◽  
Amy M Grooters
Keyword(s):  
Antifungal Therapy ◽  
Systemic Antifungal Therapy

Use of Antifungal Therapy in Hospitalized Patients II. Results after the Marketing of Fluconazole

1994 ◽  
Vol 28 (2) ◽  
pp. 261-270 ◽  
Author(s):  
Thaddeus H. Grasela ◽  
Mary T. Pasko ◽  
S. Diane Goodwin ◽  
Cynthia A. Walawander ◽  
Nicole Blackwelder ◽  
...  
Keyword(s):  
Phase I ◽  
Amphotericin B ◽  
Phase Ii ◽  
Antifungal Therapy ◽  
Antifungal Agent ◽  
Phase I Study ◽  
Antifungal Agents ◽  
Hospitalized Patients ◽  
Prescribing Patterns ◽  
Systemic Antifungal Therapy

OBJECTIVE: To evaluatethe prescribing patternsof antifungal agents in the hospital setting after the introduction of fluconazole, a new broad-spectrum bis-triazole antifungal agent. Also comparedare the prescribing patterns of antifungal agents prior to (phase I) and following (phase II) fluconazole marketing. DESIGN: A prospective cohort of hospitalized patients prescribed topical or systemic antifungal agents. Data were collected from December 1990 to April 1991. SETTING: Fifty-seven hospitals ranging in size from 100 to more than 500 beds. Sixty-three percentare affiliated with medical schools. PATIENTS: Participating pharmacists consecutively identified 15 patients receiving systemic antifungal therapy and 5 patients receiving topical antifungal therapy. INTERVENTIONS: Observational data on patient antifungal therapy, risk factors for fungal infections, comorbidities, concurrent medications, and culture data were collected. MEASURES: Differences in prescribing patterns before and after the marketing of fluconazole were assessed using t-tests and chi-square tests. RESULTS: Of 818 patients studied, 615 (75.2 percent) received systemic antifungal therapy. Five hundred forty-six patients received a single antifungal agent; 348 (63.7 percent) received fluconazole, 105 (19.2 percent) received ketoconazole, 92 (16.8 percent) received amphotericin B, and 1 (0.2 percent) received flucytosine. Sixty-nine patients received two or more systemic agents either concurrently or consecutively. The use of parenteral amphotericin B, alone or in combination with flucytosine and/or an azole, declined from 56.8 percent in the phase I study to 24.2 percent in the current study. The use of parenteral therapy also declined from 56.8 to 40.2 percent. Ketoconazole was used in more than 90 percent of the oral and esophageal infections in the phase I study, but its use declined to only 33 percent in this study. Fluconazole was used most frequently across all sites of presumed or documented infections, with the exception of fungemia. Of the presumed or proven systemic or blood infections, amphotericin B was used alone or in combination in 48.4 percent of the patients and fluconazole was used exclusively in 39.0 percent of the patients. Fluconazole was used more often than amphotericin B (22 vs. 3 patients, respectively) for prophylaxis of systemic infections. The overall use of antifungal prophylaxis also increased from the phase I (9.5 percent) to phase II (13.7 percent). CONCLUSIONS: The introduction of fluconazole had a major impact on the prescribing patterns of antifungal therapy. Although amphotericin B remained the preferred agent for treatment of suspected or proven systemic, central nervous system, or blood infections, use of fluconazole for these indications approached nearly 40 percent. Further studies are needed to address the role of fluconazole in the prophylaxis and treatment of systemic mycoses.

Overview of Oral Azole Drugs as Systemic Antifungal Therapy

1997 ◽  
Vol 18 (03) ◽  
pp. 301-309 ◽  
Author(s):  
Craig Hoesley ◽  
William Dismukes
Keyword(s):  
Antifungal Therapy ◽  
Systemic Antifungal Therapy

Oral Azole Drugs as Systemic Antifungal Therapy

1994 ◽  
Vol 330 (4) ◽  
pp. 263-272 ◽  
Author(s):  
Alastair J.J. Wood ◽  
Jackson A. Como ◽  
William E. Dismukes
Keyword(s):  
Antifungal Therapy ◽  
Systemic Antifungal Therapy

Failure of Empirical Systemic Antifungal Therapy in Mechanically Ventilated Critically Ill Patients

2015 ◽  
Vol 191 (10) ◽  
pp. 1139-1146 ◽  
Author(s):  
Sébastien Bailly ◽  
Lila Bouadma ◽  
Elie Azoulay ◽  
Maité Garrouste Orgeas ◽  
Christophe Adrie ◽  
...  
Keyword(s):  
Critically Ill ◽  
Antifungal Therapy ◽  
Critically Ill Patients ◽  
Mechanically Ventilated ◽  
Systemic Antifungal Therapy

Summary of ‘Systemic antifungal therapy for tinea capitis in children’

2011 ◽  
Vol 6 (5) ◽  
pp. 1772-1773
Author(s):  
Evidence-Based Child Health Editorial Office
Keyword(s):  
Antifungal Therapy ◽  
Tinea Capitis ◽  
Systemic Antifungal Therapy

Oral azole drugs as systemic antifungal therapy

1995 ◽  
Vol 32 (1) ◽  
pp. 119
Author(s):  
Kenneth Tomecki
Keyword(s):  
Antifungal Therapy ◽  
Systemic Antifungal Therapy
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