Iron-Responsive Elements and Iron Regulatory Proteins

2001 ◽  
pp. 449-490
Keyword(s):  
Regulatory Proteins ◽  
Iron Regulatory Proteins ◽  
Iron Responsive Elements

The iron regulatory proteins are defective in repressing translation via exogenous 5′ iron responsive elements despite their relative abundance in leukemic cellular models

Metallomics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 639-649
Author(s):  
Emmanuel Pourcelot ◽  
Marine Lénon ◽  
Peggy Charbonnier ◽  
Fiona Louis ◽  
Pascal Mossuz ◽  
...  
Keyword(s):  
Relative Abundance ◽  
Regulatory Proteins ◽  
Iron Regulatory Proteins ◽  
Cellular Models ◽  
Iron Responsive Elements

Endogenous IRP outnumbers IRE-containing mRNA but fails to bind to transfected exogenous ones.

Iron-regulatory proteins, iron-responsive elements and ferritin mRNA translation

1999 ◽  
Vol 31 (10) ◽  
pp. 1139-1152 ◽  
Author(s):  
Andrew M Thomson ◽  
Jack T Rogers ◽  
Peter J Leedman
Keyword(s):  
Mrna Translation ◽  
Regulatory Proteins ◽  
Iron Regulatory Proteins ◽  
Iron Responsive Elements

scholarly journals Combinatorial mRNA Regulation: Iron Regulatory Proteins and Iso-iron-responsive Elements (Iso-IREs)

2000 ◽  
Vol 275 (52) ◽  
pp. 40659-40662 ◽  
Author(s):  
Elizabeth C. Theil ◽  
Richard S. Eisenstein
Keyword(s):  
Regulatory Proteins ◽  
Iron Regulatory Proteins ◽  
Mrna Regulation ◽  
Iron Responsive Elements

scholarly journals Iron Regulatory Proteins, Iron Responsive Elements and Iron Homeostasis

1998 ◽  
Vol 128 (12) ◽  
pp. 2295-2298 ◽  
Author(s):  
Richard S. Eisenstein ◽  
Kenneth P. Blemings
Keyword(s):  
Iron Homeostasis ◽  
Regulatory Proteins ◽  
Iron Regulatory Proteins ◽  
Iron Responsive Elements

scholarly journals Bacterial effector targeting of a plant iron sensor facilitates iron acquisition and pathogen colonization

2021 ◽  
Author(s):  
Yingying Xing ◽  
Ning Xu ◽  
Deepak D Bhandari ◽  
Dmitry Lapin ◽  
Xinhua Sun ◽  
...  
Keyword(s):  
Pseudomonas Syringae ◽  
Iron Uptake ◽  
Iron Acquisition ◽  
Iron Accumulation ◽  
Regulatory Proteins ◽  
Mineral Nutrient ◽  
Effector Protein ◽  
Iron Regulatory Proteins ◽  
Protein Levels ◽  
Pathogen Colonization

Abstract Acquisition of nutrients from different species is necessary for pathogen colonization. Iron is an essential mineral nutrient for nearly all organisms, but little is known about how pathogens manipulate plant hosts to acquire iron. Here, we report that AvrRps4, an effector protein delivered by Pseudomonas syringae bacteria to plants, interacts with and targets the plant iron sensor protein BRUTUS (BTS) to facilitate iron uptake and pathogen proliferation in Arabidopsis thaliana. Infection of rps4 and eds1 by P. syringae pv. tomato (Pst) DC3000 expressing AvrRps4 resulted in iron accumulation, especially in the plant apoplast. AvrRps4 alleviates BTS-mediated degradation of bHLH115 and ILR3(IAA-Leucine resistant 3), two iron regulatory proteins. In addition, BTS is important for accumulating immune proteins Enhanced Disease Susceptibility1 (EDS1) at both the transcriptional and protein levels upon Pst (avrRps4) infections. Our findings suggest that AvrRps4 targets BTS to facilitate iron accumulation and BTS contributes to RPS4/EDS1-mediated immune responses.

Abstract 2006: The contributions of iron regulatory proteins 1 and 2 to ferroptosis activation and ferroptotic cell death

2021 ◽  
Author(s):  
Evan Hermann ◽  
Thais Oliveira ◽  
McKale Montgomery
Keyword(s):  
Cell Death ◽  
Regulatory Proteins ◽  
Iron Regulatory Proteins

scholarly journals Dietary Iron Intake Modulates the Activity of Iron Regulatory Proteins and the Abundance of Ferritin and Mitochondrial Aconitase in Rat Liver

1997 ◽  
Vol 127 (2) ◽  
pp. 238-248 ◽  
Author(s):  
Opal S. Chen ◽  
Kevin L. Schalinske ◽  
Richard S. Eisenstein
Keyword(s):  
Rat Liver ◽  
Regulatory Proteins ◽  
Dietary Iron ◽  
Iron Intake ◽  
Iron Regulatory Proteins ◽  
Mitochondrial Aconitase
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