Higher Iron Intake Is Independently Associated with Obesity in Younger Japanese Type-2 Diabetes Mellitus Patients

We aimed to analyze the association between dietary iron intake and obesity assessed by BMI after adjustment for nutrient intake (macronutrients and fiber) and food groups. The study design was cross-sectional. Patients with type-2 diabetes (n = 1567; 63.1% males; mean age 62.3 ± 11.6 years) were included in the study. To assess diet, consumption of typical food groups was determined by a food frequency questionnaire. Obesity was defined as BMI ≥ 25 kg/m2. We performed a binary regression analysis between quartiles of iron intake and obesity by quartiles of age group. A direct linear association was found for the highest quartile of iron intake and obesity in the younger age group of 30 to 54 years (OR = 3.641, 95% CI = 1.020–12.990; p trend = 0.011). Multivariate analysis using food groups as opposed to nutrients revealed a positive trend for obesity in the younger age group after adjusting for lifestyle factors, energy intake and bean and vegetable intake (p trend = 0.023). In all participants, an inverse association was observed before adjustment by vegetable intake (OR = 0.453, 95% CI = 0.300–0.684; p trend = 0.001). Higher iron intake was associated with obesity independent of macronutrient and fiber intake but only in the youngest quartile of age group examined.

Gambaran Kejadian Anemia Pada Ibu Hamil : Literature Review

Pregnant women are very susceptible to anemia due to lack of food reserves and before pregnancy they were already anemic. Pregnant women need more iron intake than before pregnancy. Problems in pregnant women are problems in pregnancy that can cause anemia. This literature review aims to determine the description of the incidence of anemia in pregnant women from various articles. This study uses a descriptive method with a literature review approach. Search articles through PubMed and Google Scholar according to keywords and then analyzed according to inclusion and exclusion criteria and found 5 articles and reviewed using the Joanna Instrument (JBI). The description of the incidence of anemia in pregnant women showed anemia as many as 258 respondents (35.3%) and those who experienced anemia were not as many as 472 respondents (64.7%). In this literature review, it was concluded that most pregnant women did not experience anemia.Keywords: Anemia, Pregnant Women AbstrakIbu hamil sangat rentan mengalami anemia karena cadangan makanan kurang dan pada saat sebelum hamil sudah mengalami anemia. Ibu hamil membutuhkan asupan zat besi yang lebih banyak dibandingkan saat sebelum hamil. Permasalahan pada ibu hamil adalah masalah – masalah dalam kehamilan yang dapat menimbulkan anemia. Literatur Review ini bertujuan untuk mengetahui Gambaran Kejadian Anemia Pada Ibu Hamil dari berbagai artikel. Penelitian ini menggunakan metode deskriptif dengan pendekatan literature review. Pencarian artikel melalui PubMed dan Google Scholar sesuai dengan kata kunci kemudian dianalisa sesuai dengan keriteria inklusi dan ekslusi dan ditemukan 5 artikel dan di review menggunakan Instrument Joanna (JBI). Gambaran kejadian Anemia pada ibu hamil didapatkan hasil anemia sebanyak 258 responden (35,3%) dan yang mengalami tidak anemia sebanyak 472 responden (64,7%). Dalam penelitian literature review ini disimpulkan bahwa sebagian besar ibu hamil tidak mengalami anemia.Kata kunci : Anemia, Ibu Hamil

Complementary Feeding and Iron Status: “The Unbearable Lightness of Being” Infants

The complementary feeding (CF) period that takes place between 6 and 24 months of age is of key importance for nutritional and developmental reasons during the transition from exclusively feeding on milk to family meals. In 2021, a multidisciplinary panel of experts from four Italian scientific pediatric societies elaborated a consensus document on CF, focusing in particular on healthy term infants. The aim was to provide healthcare providers with useful guidelines for clinical practice. Complementary feeding is also the time window when iron deficiency (ID) and iron deficiency anemia (IDA) are most prevalent. Thus, it is appropriate to address the problem of iron deficiency through nutritional interventions. Adequate iron intake during the first two years is critical since rapid growth in that period increases iron requirements per kilogram more than at any other developmental stage. Complementary foods should be introduced at around six months of age, taking into account infant iron status.

Pre-Clinical Insights into the Iron and Breast Cancer Hypothesis

Population studies, systematic reviews, and meta-analyses have revealed no relationship between iron status and breast cancer, a weak positive association, or a small protective effect of low iron status. However, in those studies, the authors concluded that further investigation was merited. The set of experiments reported here used preclinical models to assess the likely value of further investigation. The effects of iron status on the initiation and promotion stage of mammary carcinogenesis are reported. Using the classical model of cancer initiation in the mammary gland, 7,12 dimethyl-benz[α]anthracene-induced carcinogenesis was unaffected by iron status. Similarly, excess iron intake showed no effect on the promotion stage of 1-methyl-1-nitrosurea-induced mammary carcinogenesis, though iron deficiency exerted a specific inhibitory effect on the carcinogenic process. Though iron-mediated cellular oxidation is frequently cited as a potential mechanism for effects on breast cancer, no evidence of increased oxidative damage to DNA attributable to excess iron intake was found. The reported preclinical data fail to provide convincing evidence that the further evaluation of the iron–breast cancer risk hypotheses is warranted and underscore the value of redefining the referent group in population-based studies of iron–cancer hypotheses in other tissues.

Variability in Oral Iron Prescription and the Effect on Spanish Mothers’ Health: A Prospective Longitudinal Study

Background: No consensus exists regarding the hemoglobin (Hb) values that define postpartum anemia. Knowledge is currently lacking regarding prescription and consumption practices, which prevents evaluating the rational use of iron supplementation postpartum. Aim: In this study, our objective was to describe this practice and analyze its association with maternal health outcomes. Methods: A prospective observational study was conducted with 1010 women aged between 18 and 50. The hemoglobin value on the first postpartum day; the prescription schedule at hospital discharge; iron consumption; and data on hemoglobin, serum ferritin, maternal fatigue, type of breastfeeding, and perceived health six weeks after delivery were collected. Findings: Oral iron was prescribed to 98.1% of mothers with anemia and 75.8% without anemia. At the same Hb value, the maximum amount of total iron prescribed was between 8 and 10 times greater than the minimum amount. Iron intake was significantly lower than prescribed (p < 0.01). At six weeks, anemic mothers who took iron presented a 3.6-, 3-, and 2.4-times lower probability of iron deficiency, anemia, and abandoning breastfeeding, respectively. Discussion: Postpartum iron intake shows a protective effect on iron deficiency and anemia at six weeks, but not on fatigue or self-perceived health level. Conclusion: We conclude that there is wide variability in the prescription regimen. Oral iron supplementation can benefit mothers with anemia and harm those without. Subsequent studies should further explore the Hb figure that better discriminates the need for postpartum iron.

Duodenal Pseudomelanosis: A Literature Review

Duodenal pseudomelanosis (also known as pseudomelanosis duodeni) is a rare endoscopic incidental finding defined by a pigmentation limited to the apex of the intestinal villi, which requires histological confirmation. While its exact pathogenesis is still poorly understood, it appears free from clinical consequences. This condition is believed to be associated with oral iron intake, antihypertensive drugs containing a sulfur moiety (i.e., hydralazine, furosemide), and several chronic diseases (i.e., hypertension, end-stage renal disease, diabetes). However, the exact prevalence of these treatments and comorbidities among patients with duodenal pseudomelanosis is not clearly defined. Several case reports and case series about duodenal pseudomelanosis have been published in recent years. In this review, we aimed to clearly define its endoscopic and microscopic presentation; its epidemiology, associated comorbidities, and drugs; the most useful special histochemical techniques used to classify the nature of the pigmentation; and the most relevant differential diagnoses. In addition, by considering our findings, we also formulated a number of hypotheses about its pathogenesis.

Dietary Iron Consumption Estimates Among Women Of Reproductive Age In Kersa, Eastern Ethiopia: Cross-Sectional Study

Dietary iron inadequacy is a public health concern in developing countries. Women of reproductive age (WRA) are the most at risk for this micronutrient deficiency due to biological, socio-cultural, and dietary factors. This analysis aimed to assess estimated dietary intakes of iron (including heme and non-heme) and estimate bioavailability of dietary iron intake in Ethiopian women of reproductive age in Kersa district, Eastern Ethiopia. A total of 1140 randomly selected women from households in Kersa participated in this study. We used a non-quantitative food frequency questionnaire to assess total dietary iron consumption in WRA. Adjusted prevalence ratios (APRs) and 95% confidence intervals (CIs) were computed using modified Poisson regression to evaluate factors for inadequate dietary iron intake. The median usual iron consumption was 24.7 mg/d and 41.8 % of WRA were at risk for iron inadequacy. The following factors were associated with a greater likelihood for the risk of iron inadequacy: seasonal (APR 1.56; 95% CI 1.36-1.80) and part-time (APR 1.75; 95% CI 1.45-2.12) agricultural employment, market food source (APR 1.30; 95% CI 1.14-1.49), old age (APR 1.29; 95% CI 1.05-1.60) and low women’s dietary diversity (APR 2.34; 95% CI 1.88-2.91). Two-fifths of women had an inadequate dietary iron intake. Improving dietary diversity and food security, fortifying staple foods that have low iron bioavailability, and increasing animal-based foods and fruit consumption with meals would help to decrease the burden of iron dietary inadequacy and deficiency in WRA.

The Effect of Nutrition Education Using Pocketbook Media on Iron and Protein Intake

The provision of nutrition education for teenage girls is an alternative to increase protein and iron intake to prevent anemia. This study aims to determine nutrition education's effect using pocketbook media on protein and iron intake in teenage girls. The research design used was quasi-experimental with a control group pre and post-test design. Sampling was done by the purposive sampling method—statistical analysis using Paired Samples T-test, Wilcoxon, Independent Samples T-test, and Mann Whitney. This study indicates an influence of nutrition education using pocketbook media on protein intake (p = 0.000) and iron (p = 0.000) in the treatment group. There is no effect of nutrition education using PowerPoint on protein intake (p = 0.326) and substances iron (p = 0.52) in the control group. Statistically, there was a significant difference between protein intake (p = 0.000) and iron (p = 0.001) of the treatment and control groups. It is recommended that UKS and students work together to conduct nutrition education routinely so that the nutrition information delivered can be given to all students in the school to prevent nutritional anemia.