For the needs of laboratory equipment management, combined with development of RFID, a laboratory equipment management system is designed based on RFID. System design is briefly described. UHF RFID reader design is described in detail. The anti-collision algorithm of ISO 18000-6C protocol is partially improved, so that the reader is able to make real-time adaptations of the anti-collision algorithm using IAP according to the quantity of laboratory equipments, thus raising the efficiency of algorithm recognition. Experimental results prove that the system design has reliability, stability and certain practical value.