Prostaglandin F2 alpha mediates platelet-activating factor-stimulated atrial natriuretic factor release from the isolated rat heart.

Endocrinology ◽  
1993 ◽  
Vol 133 (3) ◽  
pp. 1108-1115 ◽  
Author(s):  
T E Rayner ◽  
B N Chen ◽  
J W McLoughlin ◽  
M F Menadue ◽  
R J Norman ◽  
...  
Keyword(s):  
Rat Heart ◽  
Atrial Natriuretic Factor ◽  
Platelet Activating Factor ◽  
Isolated Rat Heart ◽  
Prostaglandin F2 Alpha ◽  
Natriuretic Factor ◽  
Isolated Rat ◽  
Factor Release ◽  
Atrial Natriuretic

Platelet-activating factor stimulates the release of atrial natriuretic factor from the rat heart

1991 ◽  
Vol 130 (2) ◽  
pp. 281-288 ◽  
Author(s):  
T. E. Rayner ◽  
M. F. Menadue ◽  
J. R. Oliver
Keyword(s):  
Rat Heart ◽  
Atrial Natriuretic Factor ◽  
Isolated Heart ◽  
Platelet Activating Factor ◽  
Natriuretic Factor ◽  
Paf Receptor ◽  
Factor Α ◽  
Paf Receptor Antagonist ◽  
Atrial Natriuretic

ABSTRACT Atrial natriuretic factor (α-ANF(99–126); ANF) is released from atrial cells following atrial distension, myocardial infarction and periods of ischaemic or tachyarrhythmias. In this report we demonstrate that platelet-activating factor (PAF) stimulates ANF release from the isolated perfused rat heart and following i.v. injection to conscious unrestrained rats. ANF release peaked at 145% above baseline following injection of 2·5 nmol PAF into the isolated heart while administration of 2 nmol in vivo produced a 135% increase in plasma ANF levels. The PAF receptor antagonist BN52021 (10 μmol/l) attenuated this stimulated release, with the results suggesting a role for PAF in ANF secretion following release from damaged myocardium or as a humoral factor originating from the kidney. Journal of Endocrinology (1991) 130, 281–288

Control of atrial natriuretic factor release from a rat heart-lung preparation

1987 ◽  
Vol 252 (3) ◽  
pp. R498-R502 ◽  
Author(s):  
J. R. Dietz
Keyword(s):  
Rat Heart ◽  
Atrial Natriuretic Factor ◽  
Venous Return ◽  
Sodium Concentration ◽  
Aortic Pressure ◽  
Plasma Sodium ◽  
Natriuretic Factor ◽  
Time Period ◽  
Lung Preparation ◽  
Atrial Natriuretic

These experiments examined the effects of altering venous return, aortic pressure, or perfusate sodium concentration on the release of atrial natriuretic factor (ANF) from a rat heart-lung preparation. Changes in perfusate ANF concentration during each time period (delta ANF) were used as an index of ANF secretion. Raising the height of the venous return reservoir from 2-3 to 5-7 cm above the heart increased delta ANF from 88 +/- 19 to 748 +/- 154 pg X ml-1 X 10 min-1 (P less than 0.01, n = 7). In control experiments where the height of the reservoir was not increased, delta ANF was unchanged (65 +/- 35 vs. 43 +/- 26 pg X ml-1 X 10 min-1, n = 6). Increasing aortic pressure from 60 to 100 mmHg increased ANF from 43 +/- 10 to 107 +/- 20 pg X ml-1 X 15 min-1 (P less than 0.05, n = 6). Separate groups of heart-lung preparations were perfused with solutions with sodium concentrations of 132 +/- 1, 144 +/- 2, or 166 +/- 1 meq/l (n = 8/group). delta ANF was 45 +/- 14, 50 +/- 17, and 52 +/- 22 pg X ml-1 X 10 min-1, respectively. These values were not significantly different. These results suggest that ANF plays a role in the control of blood volume and blood pressure but do not support a role for ANF in the control of plasma sodium concentration.

Identification of the Released form of Atrial Natriuretic Factor by the Perfused Rat Heart

1986 ◽  
Vol 182 (1) ◽  
pp. 137-141 ◽  
Author(s):  
G. Thibault ◽  
R. Garcia ◽  
J. Gutkowska ◽  
C. Lazure ◽  
N. G. Seidah ◽  
...  
Keyword(s):  
Rat Heart ◽  
Atrial Natriuretic Factor ◽  
Perfused Rat Heart ◽  
Natriuretic Factor ◽  
Atrial Natriuretic
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