Interferon-gamma suppresses thyrotropin receptor promoter activity by reducing thyroid transcription factor-1 (TTF-1) binding to its recognition site

1996 ◽  
Vol 10 (7) ◽  
pp. 826-836 ◽  
Author(s):  
K. Ohe
Keyword(s):  
Transcription Factor ◽  
Interferon Gamma ◽  
Promoter Activity ◽  
Recognition Site ◽  
Thyrotropin Receptor ◽  
Thyroid Transcription Factor 1 ◽  
Thyroid Transcription Factor ◽  
Transcription Factor 1

scholarly journals Synergistic transcriptional activation of the thyrotropin receptor promoter by cyclic AMP-responsive-element-binding protein and thyroid transcription factor 1

1995 ◽  
Vol 310 (2) ◽  
pp. 491-496 ◽  
Author(s):  
A Saiardi ◽  
P Falasca ◽  
D Civitareale
Keyword(s):  
Transcription Factor ◽  
Cyclic Amp ◽  
Promoter Activity ◽  
Binding Protein ◽  
Specific Gene ◽  
Thyrotropin Receptor ◽  
Thyroid Transcription Factor 1 ◽  
Thyroid Transcription Factor ◽  
Responsive Element ◽  
Transcription Factor 1

In this study we have investigated the molecular mechanisms involved in hormonal induction of thyroid-specific transcription of the thyrotropin receptor (TSHr). A cyclic AMP-responsive element (CRE) has been characterized in the minimal TSHr promoter, and promoter activity shown to be also induced by thyroid transcription factor 1 (TTF-1). We here describe a cooperative effect between TTF-1 and CRE-binding protein on the TSHr promoter. Moreover we have identified a second TTF-1-binding site in the minimal promoter, which does not activate TSHr promoter activity but is required for the co-operative activation of the promoter. This report describes a new aspect of thyroid-specific gene expression, namely, how a generic extracellular signal can be interpreted in a thyroid-specific way.

scholarly journals Thyroid Transcription Factor-1 Activates the Promoter Activity of Rat Thyroid Na+/I−Symporter Gene

1997 ◽  
Vol 11 (11) ◽  
pp. 1747-1755 ◽  
Author(s):  
Toyoshi Endo ◽  
Masahiro Kaneshige ◽  
Minoru Nakazato ◽  
Masayuki Ohmori ◽  
Norikazu Harii ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Promoter Activity ◽  
Thyroid Transcription Factor 1 ◽  
Thyroid Transcription Factor ◽  
Rat Thyroid ◽  
Transcription Factor 1
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