Editors' note: Migraine progression in subgroups of migraine based on comorbidities: Results of the CaMEO Study

Neurology ◽  
2020 ◽  
Vol 95 (15) ◽  
pp. 706.2-706
Author(s):  
James E. Siegler ◽  
Steven Galetta
Keyword(s):  



2019 ◽  
Vol 22 ◽  
pp. S283
Author(s):  
L. Li ◽  
L. Mueller ◽  
C. Hitchcock ◽  
R. Zyoud ◽  
J. Bell ◽  
...  


Cephalalgia ◽  
2017 ◽  
Vol 38 (4) ◽  
pp. 776-785 ◽  
Author(s):  
Radhouane Dallel ◽  
Amélie Descheemaeker ◽  
Philippe Luccarini

Background A subgroup of migraineurs experience an increase in attack frequency leading to chronic migraine. Methods We assessed in rats the roles of dose and repeat administration of systemic isosorbide dinitrate (ISDN), a nitric oxide donor, on the occurrence and development of cephalic/face and extracephalic/hindpaw mechanical allodynia as a surrogate of migraine pain, and the effect of acute systemic sumatriptan and olcegepant and chronic systemic propranolol on these behavioral changes. Results A single high (H-ISDN) but not low (L-ISDN) dose of ISDN induces a reversible cephalic and extracephalic mechanical allodynia. However, with repeat administration, L-ISDN produces reversible cephalic but never extracephalic allodynia, whereas H-ISDN induces cephalic and extracephalic allodynia that are both potentiated. H-ISDN-induced cephalic allodynia thus gains persistency. Sumatriptan and olcegepant block single H-ISDN-induced behavioral changes, but only olcegepant reduces these acute changes when potentiated by repeat administration. Neither sumatriptan nor olcegepant prevent chronic cephalic hypersensitivity. Conversely, propranolol blocks repeat H-ISDN-induced chronic, but not acute, behavioral changes. Conclusions Repeated ISDN administration appears to be a naturalistic rat model for migraine progression, suitable for screening acute and preventive migraine therapies. It suggests frequent and severe migraine attacks associated with allodynia may be a risk factor for disease progression.



2013 ◽  
Vol 53 (6) ◽  
pp. 930-934 ◽  
Author(s):  
Richard B. Lipton ◽  
Donald B. Penzien ◽  
Dana P. Turner ◽  
Todd A Smitherman ◽  
Timothy T. Houle


Neurology ◽  
2020 ◽  
Vol 95 (15) ◽  
pp. 707.2-708
Author(s):  
Richard B. Lipton ◽  
Kristina M. Fanning ◽  
Dawn C. Buse ◽  
Vincent T. Martin ◽  
Lee B. Hohaia ◽  
...  


2011 ◽  
pp. 5-9
Author(s):  
Juliane P. P. Mercante ◽  
Mario F. P. Peres ◽  
Marcio A. Bernik ◽  
Felipe Corchs ◽  
Vera Z. Guendler ◽  
...  

Background: Psychiatric conditions, mostly anxiety and mood disorders, are common in patients with chronic migraine. There has recently been extensive debate on migraine progression, but little is known about the role of psychiatric disorders in this respect. Objective: In order to evaluate the role of psychiatric disorders in migraine progression, we analyzed the temporal profile of migraine, mood and anxiety disorders, and years since onset of symptoms in chronic migraine (CM) patients. Methods: Fifty CM patients diagnosed according to the International Headache Society (2004) criteria were interviewed and diagnosed for mental disorders using the Structured Clinical Interview for DSM-IV (SCID-I/P). Results: Anxiety disorders preceded the onset of episodic migraine, which was followed by depression and daily headaches. Conclusions: Psychiatric comorbidity evaluation in chronic migraine may lead to better patient management and clinical outcomes. Patients with a history of anxiety, episodic migraine, and depression may be at risk of developing CM. Early treatment of anxiety, mood disorders, and episodic migraine may prevent disease progression to CM.



Neurology ◽  
2008 ◽  
Vol 71 (22) ◽  
pp. 1821-1828 ◽  
Author(s):  
M. E. Bigal ◽  
R. B. Lipton


2017 ◽  
Vol 95 (1) ◽  
pp. 15-22
Author(s):  
Vadim A. Akhmedov ◽  
O. V. Gaus

This review article highlights the modern views of manifestations associated with Hp infection. The data are presented about the negative impact of the infection on the state of the musculoskeletal system, the development of migraine, progression of diffuse liver disease and the risk of developing liver cancer. The paper also provides information on the possible effects of Helicobacter pylori infection on the formation of halitosis, tympanosclerosis, male reproductive health disorders, colorectal cancer, Alzheimer's and Parkinson's disease, pre-eclampsia during pregnancy, and idiopathic chronic urticaria. In addition, the negative relationship between Hp infection, bronchial asthma, and inflammatory bowel disease is considered.



2019 ◽  
Vol 59 (7) ◽  
pp. 974-976
Author(s):  
Dawn C. Buse ◽  
Jacob D. Greisman ◽  
Khosrow Baigi ◽  
Richard B. Lipton




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