In their recent letter entitled "Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease", Liu and colleagues report that in a genome-wide analysis of progression to dementia in Parkinson's disease (PD) the RIMS2 locus is a determinant of dementia in PD (1). In this study we have evaluated the nominated loci in a well-powered longitudinal clinical-genetic study of 2536 individuals in the Tracking Parkinson's and Oxford Discovery cohorts. We have not identified any association between the RIMS2 locus or other loci from the discovery phase and the development of Parkinson's dementia. Further work is needed to understand the biological determinants of this important aspect of Parkinson's and to guide the search for new treatments.
Evaluation Of The Rims2 Locus As A Risk Locus For Parkinson's Disease Dementia
