Background / Aim. In spite of continuous research efforts, specific
laboratory, neuropsychological or neurophysiological tests for the diagnosis
of Parkinson?s disease have not been established. The aims of the paper are
to determine the nature and extent of visual pathway disorders on ?pattern?
electroretinogram and visual evoked potentials in certain stages of
Parkinson's disease. Methods. The study was carried out in a group of 60
persons of both sexes, who were suffering from idiopathic Parkinson's
disease at the I-IV stage of the disease according to the Hoehn and Yahr
scale, and 30 healthy persons in the control group. The battery of
non-invasive neurophysiological tests was used to estimate the functional
status of the visual pathway: "pattern" electroretinography (PERG) and
visual evoked potentials (VEP). Results. In the early phase of PB there is a
linear increase in the latency of the wave N50 of the "pattern"
electroretinogram and the wave P100 of the visual evoked potentials with
significant extension of the latency of the N50 and P100 waves in subsequent
stages of Parkinson's disease. Diagnostic application of the "pattern"
electroretinography and visual evoked potentials enables the confirmation of
a disorder in the visual pathway function in Parkinson's disease.
Conclusions. These neurophysiological techniques may record early changes in
the function of retinal structures and the optic nerve in PD, which might be
significant both from the diagnostic and therapeutic aspects.