Total Recall: Production, Revolution, Simulation-Alienation Effect

In recent decades, postmodern, poststructuralist, and social constructivist theories, and the methodologies and methods they have informed, have been criticized for focusing primarily on human actors, discourses, and actions. Simultaneously, so-called posthuman theories have been developed that decentralize the human, reject an unquestioned use of the dualism of human/nonhuman, and emphasize the importance of the material world in the production of the social. A key concern for current qualitative inquiry is to develop methods that contribute to the critique of human-centered analysis. In this article, I explore what we learn about the material world when we do not use verbal methods or written data but image details of moveable formations, which are made into silhouettes using Karen Barad’s agential realism. After introducing posthuman methodology I perform a silhouettes analysis focusing on old age. The intention is to demonstrate that silhouettes analysis makes it possible to gain new insights into the features of materialities of old age in a way that classical image analysis would not allow. In addition, silhouettes analysis produces an alienation effect that disturbs practiced viewing habits and assumptions, and can thus serve as a research tool promoting reflection. I conclude with a discussion of the advantages and limitations of silhouettes analysis for gerontological and posthuman research.

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SARS-CoV-2 immunity and HIV infection: total recall?

The Lancet HIV ◽

10.1016/s2352-3018(21)00097-7 ◽

2021 ◽

Author(s):

Nicolas Dauby ◽

Charlotte Martin

Keyword(s):

Hiv Infection ◽

Total Recall

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CTNI-51. NEUROCOGNITIVE FUNCTION (NCF) OUTCOMES OF RTOG FOUNDATION 3508: A PHASE 3 TRIAL OF ABT-414 WITH CONCURRENT CHEMORADIATION AND ADJUVANT TEMOZOLOMIDE IN PATIENTS WITH EGFR-AMPLIFIED NEWLY DIAGNOSED GBM

Neuro-Oncology ◽

10.1093/neuonc/noaa215.217 ◽

2020 ◽

Vol 22 (Supplement_2) ◽

pp. ii54-ii54

Author(s):

Jeffrey S Wefel ◽

Minhee Won ◽

Andrew Lassman ◽

Yaakov Stern ◽

Tony Wang ◽

...

Keyword(s):

Learning And Memory ◽

Verbal Learning ◽

Concurrent Chemoradiation ◽

Reliable Change Index ◽

Newly Diagnosed ◽

Total Recall ◽

Phase 3 ◽

Delayed Recall ◽

Adjuvant Temozolomide ◽

Over Time

Abstract RTOG 3508/AbbVie M13-813/INTELLANCE-1 was a phase 3 trial of depatuximab-mafodotin (depatux-m, formerly ABT-414) that accrued 639 patients with EGFR-amplified newly diagnosed GBM. At the pre-specified interim OS analysis, the futility criteria were met and there was no survival benefit from adding depatux-m to SOC. Pre-specified secondary NCF analyses included time to decline in verbal learning and memory as assessed by the HVLT-R Total Recall based on the reliable change index. Exploratory NCF analyses examined changes in other HVLT-R outcomes over time. As corneal epitheliopathy causing visual impairment is a known toxicity of depatux-m, NCF tests that did not depend on visual acuity were employed. NCF testing occurred at baseline, day 1 of the first cycle of adjuvant depatux-m, every other cycle (i.e., 8 weeks) thereafter, and at progression. Compliance with test completion was 95% at screening and 80%, 70%, 58%, 51%, 47% thereafter through cycle 9. The most common reasons for missing data was site error. Time to HVLT-R Total Recall decline trended worse in the depatux-m arm compared to placebo but the difference was not significant (12 month deterioration: 41.2%, 95% CI: 3.50–47.2 vs 32.4%, 95% CI: 26.6- 38.4, p=0.052). The depatux-m arm, in comparison to the placebo arm, showed greater decline from baseline on the HVLT-R at the following time points: cycle 3 (Total Recall: mean= -1.8, SD=5.7 vs mean= -0.5, SD=5.5, respectively, p=0.046; Delayed Recall: mean= -1.1, SD=3.0 vs. mean= -0.2, SD=2.7, respectively, p=0.01), cycle 7 (Total Recall: mean= -0.6, SD=5.1 vs mean= 1.4, SD=5.0, respectively, p=0.009; Delayed Recall: mean -0.6, SD=3.0 vs. mean= 0.5, SD=2.7, respectively, p=0.01), and cycle 9 (Delayed Recall: mean=-0.4, SD=2.7 vs. mean= 0.8, SD=2.4, respectively, p=0.003). Depatux-m added to concurrent chemoradiation and adjuvant temozolomide was associated with faster time to deterioration and worse episodic learning and memory over time than placebo.

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