Impaired Immunocompetence in Patients with Malignant Gliomas

Neurosurgery ◽  
1982 ◽  
Vol 10 (5) ◽  
pp. 571-573 ◽  
Author(s):  
Massimo A. Gerosa ◽  
Alessandro Olivi ◽  
Mark L. Rosenblum ◽  
Gian Piero Semenzato ◽  
Antonio Pezzutto
Keyword(s):  
T Lymphocyte ◽  
Peripheral Blood ◽  
Radiation Treatment ◽  
Malignant Gliomas ◽  
Suppressor Cells ◽  
Lymphocyte Subpopulations ◽  
Helper Cells ◽  
T Lymphocyte Subpopulations ◽  
Suppressor Lymphocytes

Abstract T-lymphocyte subpopulations (Tg or “suppressor cells” and Tm or “helper cells”) in the peripheral blood of 16 patients with malignant intracranial gliomas were analyzed. The number of Tm-lymphocytes was very close to normal in both preand postoperative samples, whereas Tg-lymphocytes were significantly increased preoperatively (18.55 ± 1.11 vs. 12.72 ± 1.19, p < 0.001) and were still slightly higher than normal after operation and radiation treatment. These preliminary findings suggest a possible role of T-suppressor lymphocytes in the impairment of cell-mediated immunocompetence that has been observed repeatedly in patients with malignant gliomas.

T lymphocyte subpopulations in the bone marrow and peripheral blood of untreated patients with myeloma

1981 ◽  
Vol 11 (2) ◽  
pp. 129-137
Author(s):  
Rosario Giustolisi ◽  
Patrizia Guglielmo ◽  
Michele Rizzo ◽  
Elio Cacciola
Keyword(s):  
Bone Marrow ◽  
T Lymphocyte ◽  
Peripheral Blood ◽  
Lymphocyte Subpopulations ◽  
T Lymphocyte Subpopulations

Ferritin in normal human peripheral blood T-lymphocyte subpopulations

1984 ◽  
Vol 86 (1) ◽  
pp. 255-260 ◽  
Author(s):  
X. López-Karpovitch ◽  
M.R. Padrós-Semorile ◽  
X. Alvarez-Hernández
Keyword(s):  
T Lymphocyte ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Lymphocyte Subpopulations ◽  
T Lymphocyte Subpopulations ◽  
Normal Human ◽  
Normal Human Peripheral Blood

Characterization of rhesus macaque peripheral blood T-lymphocyte subpopulations

1983 ◽  
Vol 4 (5-6) ◽  
pp. 517-532 ◽  
Author(s):  
L.R. Ellingsworth ◽  
B.I. Osburn ◽  
L.G. Hayashi ◽  
C.A. Holmberg
Keyword(s):  
Rhesus Macaque ◽  
T Lymphocyte ◽  
Peripheral Blood ◽  
Lymphocyte Subpopulations ◽  
T Lymphocyte Subpopulations

Levels of selected T lymphocyte subpopulations in peripheral blood of mares which experienced early embryonic death

2010 ◽  
Vol 120 (1-4) ◽  
pp. 71-77 ◽  
Author(s):  
Leszek Krakowski ◽  
Cezary H. Krawczyk ◽  
Zygmunt Wrona ◽  
Roman Dąbrowski ◽  
Łukasz Jarosz
Keyword(s):  
T Lymphocyte ◽  
Peripheral Blood ◽  
Lymphocyte Subpopulations ◽  
T Lymphocyte Subpopulations ◽  
Embryonic Death

scholarly journals Lymphokine(s) from isolated T lymphocyte subpopulations support multilineage hematopoietic colony and megakaryocytic colony formation

Blood ◽  
1986 ◽  
Vol 68 (5) ◽  
pp. 991-995 ◽  
Author(s):  
L Kanz ◽  
GW Lohr ◽  
AA Fauser
Keyword(s):  
B Lymphocytes ◽  
T Lymphocyte ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Growth And Development ◽  
Bone Marrow Cells ◽  
Lymphocyte Subpopulations ◽  
Neutrophilic Granulocytes ◽  
Hematopoietic Progenitors ◽  
T Lymphocyte Subpopulations

Abstract Conditioned medium derived from peripheral mononuclear low-density cells stimulated with phytohemagglutinin (PHA) supports the growth of noncommitted hematopoietic progenitors from marrow and peripheral blood cells. These immature progenitors (CFU-GEMM) can be identified in culture as multilineage hematopoietic colonies containing erythroblasts, eosinophilic, basophilic and neutrophilic granulocytes, megakaryocytes, macrophages, and T and B lymphocytes. In this report, we describe the effect of lymphokines released from purified T lymphocyte preparations of helper (T4) and suppressor/cytotoxic (T8) phenotype derived from peripheral blood on the growth of multilineage hematopoietic colonies and megakaryocytic colonies. It was found that PHA-stimulated lymphocytes of T4 phenotype and, to a lesser extent, of T8 phenotype elaborate lymphokine(s) that support the growth and development of multilineage colonies (CFU-GEMM), granulopoietic colonies (CFU-C), erythroid bursts (BFU-E) and megakaryocytic colonies (CFU-M) by nonadherent and T cell-depleted bone marrow cells.

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