scholarly journals Novel role of Rac-Mid1 signaling in medial cerebellar development

Development ◽  
2017 ◽  
Vol 144 (10) ◽  
pp. 1863-1875 ◽  
Author(s):  
Takashi Nakamura ◽  
Takehiko Ueyama ◽  
Yuzuru Ninoyu ◽  
Hirofumi Sakaguchi ◽  
Narantsog Choijookhuu ◽  
...  
Keyword(s):  
Cerebellar Development

The role of noradrenergic fibres in the control of post-natal cerebellar development

1981 ◽  
Vol 207 (1) ◽  
pp. 200-208 ◽  
Author(s):  
J. Sievers ◽  
M. Berry ◽  
H. Baumgarten
Keyword(s):  
Cerebellar Development

The Role of Thyroid Hormone on Cerebellar Development

2008 ◽  
Vol 7 (4) ◽  
pp. 530-533 ◽  
Author(s):  
Noriyuki Koibuchi
Keyword(s):  
Thyroid Hormone ◽  
Cerebellar Development

scholarly journals Identification of limb-specific Lmx1b auto-regulatory modules with Nail-Patella Syndrome pathogenicity

2020 ◽  
Author(s):  
Endika Haro ◽  
Florence Petit ◽  
Charmaine U. Pira ◽  
Conor D. Spady ◽  
Lauren A. Ivey ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cerebellar Development ◽  
Loss Of Function ◽  
Disease Pathogenesis ◽  
Functional Allele ◽  
Regulatory Modules ◽  
Patient Families ◽  
Nail Dysplasia ◽  
Nail Patella Syndrome

AbstractLMX1B haploinsufficiency causes Nail-patella syndrome (NPS; MIM 161200), characterized by nail dysplasia, absent/hypoplastic patellae, chronic kidney disease, and glaucoma. Accordingly, in mice Lmx1b has been shown to play crucial roles in the development of the limb, kidney and eye. Although one functional allele of murine Lmx1b appears adequate for development, Lmx1b null mice display ventral-ventral distal limbs with abnormal kidney, eye and cerebellar development, more disruptive, but fully concordant with NPS. Interestingly, in Lmx1b functional knockouts (KOs), Lmx1b transcription in the limb is decreased nearly 6-fold indicating autoregulation. Herein, we report on two conserved Lmx1b-associated cis-regulatory modules (LARM1 and LARM2) that are bound by Lmx1b, amplify Lmx1b expression in the limb and are necessary for Lmx1b-mediated limb dorsalization. Remarkably, we also report on two NPS patient families with normal LMX1B coding sequence, but loss-of-function variations in the LARM1/2 region, stressing the role of regulatory modules in disease pathogenesis.

P 1086. Role of PTRH2 in Cerebellar Development

2018 ◽  
Author(s):  
Sylvie Picker-Minh ◽  
Ilaria Luperi ◽  
Magdalena John ◽  
Hao Hu ◽  
Luis Hernandez-Miranda ◽  
...  
Keyword(s):  
Cerebellar Development

scholarly journals Role of CXCL12 and CXCR4 in normal cerebellar development and medulloblastoma

2014 ◽  
Vol 138 (1) ◽  
pp. 10-13 ◽  
Author(s):  
Patricia Midori Murobushi Ozawa ◽  
Carolina Batista Ariza ◽  
Cintya Mayumi Ishibashi ◽  
Thiago Cezar Fujita ◽  
Bruna Karina Banin-Hirata ◽  
...  
Keyword(s):  
Cerebellar Development

scholarly journals A Novel and Multivalent Role of Pax6 in Cerebellar Development

2016 ◽  
Vol 36 (35) ◽  
pp. 9057-9069 ◽  
Author(s):  
J. Yeung ◽  
T. J. Ha ◽  
D. J. Swanson ◽  
D. Goldowitz
Keyword(s):  
Cerebellar Development

scholarly journals The Role of Thyroid Hormone in the Regulation of Cerebellar Development

2021 ◽  
Author(s):  
Sumiyasu Ishii ◽  
Izuki Amano ◽  
Noriyuki Koibuchi
Keyword(s):  
Thyroid Hormone ◽  
Cerebellar Development
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