Role of Nitric Oxide in Cerebellar Development and Function: Focus on Granule Neurons

Matrix metalloproteinases (MMPs) play an important role in tissue remodeling that accompanies the rapid growth, differentiation, and structural changes of the placenta and several fetal organs. In the present study, we investigated whether the diabetic maternal environment may alter the regulatory homeostasis exerted by nitric oxide (NO) on MMPs activity in the feto-placental unit from rats at midgestation. We found that NADPH-diaphorase activity, which reflects the distribution and activity of NO synthases (NOS), was increased in both placenta and fetuses from diabetic rats when compared with controls. In addition, while a NO donor enhanced MMP2 and MMP9 activities, a NOS inhibitor reduced these activities in the maternal side of the placenta from control rats. This regulatory effect of NO was only observed on MMP9 in the diabetic group. On the other hand, the NO donor did not modify MMP2 and MMP9 activities, while the NOS inhibitor reduced MMP9 activity in the fetal side of both control and diabetic placentas. In the fetuses, MMP2 was enhanced by the NO donor and reduced by the NO inhibitor in both fetuses from control and diabetic rats. Overall, this study demonstrates that NO is able to modulate the activation of MMPs in the feto-placental unit, and provides supportive evidence that increased NOS activity leads to NO overproduction in the feto-placental unit from diabetic rats, an alteration closely related to the observed MMPs dysregulation that may have profound implications in the formation and function of the placenta and the fetal organs.

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Autoregulatory Role of Endothelium-derived Nitric Oxide (NO) on Lipopolysaccharide-induced Vascular Inducible NO Synthase Expression and Function

Journal of Biological Chemistry ◽

10.1074/jbc.m411317200 ◽

2004 ◽

Vol 280 (8) ◽

pp. 7236-7243 ◽

Cited By ~ 65

Author(s):

Phuong A. Vo ◽

Bhavini Lad ◽

James A. P. Tomlinson ◽

Stephanie Francis ◽

Amrita Ahluwalia

Keyword(s):

Nitric Oxide ◽

No Synthase ◽

Inducible No Synthase ◽

And Function

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The Role of Glycocalyx and Caveolae in Vascular Homeostasis and Diseases

Frontiers in Physiology ◽

10.3389/fphys.2020.620840 ◽

2021 ◽

Vol 11 ◽

Author(s):

Simone Regina Potje ◽

Tiago Dal-Cin Paula ◽

Michele Paulo ◽

Lusiane Maria Bendhack

Keyword(s):

Nitric Oxide ◽

Reactive Oxygen Species ◽

Cardiovascular Diseases ◽

Endothelial Glycocalyx ◽

Special Focus ◽

Oxygen Species ◽

Vascular Homeostasis ◽

Structure Synthesis ◽

And Function

This review highlights recent findings about the role that endothelial glycocalyx and caveolae play in vascular homeostasis. We describe the structure, synthesis, and function of glycocalyx and caveolae in vascular cells under physiological and pathophysiological conditions. Special focus will be given in glycocalyx and caveolae that are associated with impaired production of nitric oxide (NO) and generation of reactive oxygen species (ROS). Such alterations could contribute to the development of cardiovascular diseases, such as atherosclerosis, and hypertension.

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The role of nitric oxide and its donors in uterus contractility regulation

Journal of obstetrics and women s diseases ◽

10.17816/jowd87139 ◽

1998 ◽

Vol 47 (1) ◽

pp. 58-63

Author(s):

V. V. Abramchenko ◽

L. A. Sherbina ◽

S. V. Nikitin ◽

A. V. Nikitin ◽

T. U. Kuzminih

Keyword(s):

Nitric Oxide ◽

Uterine Contraction ◽

Therapeutic System ◽

Uterine Contractility ◽

Uterine Activity ◽

The Status ◽

Interruption Management ◽

And Function ◽

Pregnancy Interruption

This article presents comprehensive data on uterine contractility regulation by nitric oxide, including systematized contemporary data on the status and function of the human nitroxidergic vasodilator system, and our experience in threat of pregnancy interruption management by nitroglycerin given with the transdermal therapeutic system Deponit 5 (Schwarz Pharma, Germany). To control contractile uterine activity in pregnant women with pathologic preliminary period, the authors successfully used sublingual application of Nitrolingual aerosol (G. Pohl-Boskamp GmbH and Co, Germany) with prolongation of the effect by the Deponit system 5. As little as five minutes after aerosol application tocography revealed a decrease in uterine contraction frequency, duration and intensity. By effecting post- and preloading and lowering the resistance of spiral arteries, vasodilators provided increased intensity of placenta circulation, which had a great importance for anteintranatal care of the fetus and newborn. The advantages of nitric oxide donator application in obstetrics were also demonstrated.

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Role of nitric oxide in placental vascular development and function

Placenta ◽

10.1016/j.placenta.2011.06.025 ◽

2011 ◽

Vol 32 (11) ◽

pp. 797-805 ◽

Cited By ~ 107

Author(s):

B.J. Krause ◽

M.A. Hanson ◽

P. Casanello

Keyword(s):

Nitric Oxide ◽

Vascular Development ◽

And Function

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Glycyrrhizin as a Nitric Oxide Regulator in Cancer Chemotherapy

Cancers ◽

10.3390/cancers13225762 ◽

2021 ◽

Vol 13 (22) ◽

pp. 5762

Author(s):

Minsu Kim ◽

Seok Chan Park ◽

Dong Yun Lee

Keyword(s):

Nitric Oxide ◽

Multidrug Resistance ◽

Tumor Microenvironment ◽

Cancer Chemotherapy ◽

Active Compound ◽

Potential Role ◽

No Production ◽

Therapeutic Benefits ◽

And Function

Chemotherapy is used widely for cancer treatment; however, the evolution of multidrug resistance (MDR) in many patients limits the therapeutic benefits of chemotherapy. It is important to overcome MDR for enhanced chemotherapy. ATP-dependent efflux of drugs out of cells is the main mechanism of MDR. Recent studies have suggested that nitric oxide (NO) can be used to overcome MDR by inhibiting the ATPase function of ATP-dependent pumps. Several attempts have been made to deliver NO to the tumor microenvironment (TME), however there are limitations in delivery. Glycyrrhizin (GL), an active compound of licorice, has been reported to both reduce the MDR effect by inhibiting ATP-dependent pumps and function as a regulator of NO production in the TME. In this review, we describe the potential role of GL as an NO regulator and MDR inhibitor that efficiently reduces the MDR effect in cancer chemotherapy.

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The Role of Nitric Oxide in Lung Growth and Function

The Newborn Lung: Neonatology Questions and Controversies ◽

10.1016/b978-1-4377-2682-4.00005-6 ◽

2012 ◽

pp. 111-132

Author(s):

Girija G. Konduri

Keyword(s):

Nitric Oxide ◽

Lung Growth ◽

And Function

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GSG1L regulates the strength of AMPA receptor-mediated synaptic transmission but not AMPA receptor kinetics in hippocampal dentate granule neurons

Journal of Neurophysiology ◽

10.1152/jn.00307.2016 ◽

2017 ◽

Vol 117 (1) ◽

pp. 28-35 ◽

Cited By ~ 9

Author(s):

Xia Mao ◽

Xinglong Gu ◽

Wei Lu

Keyword(s):

Ampa Receptor ◽

Pyramidal Neurons ◽

Granule Cells ◽

Granule Neurons ◽

Ca1 Pyramidal Neurons ◽

Auxiliary Subunit ◽

Hippocampal Ca1 ◽

Ampar Trafficking ◽

And Function

GSG1L is an AMPA receptor (AMPAR) auxiliary subunit that regulates AMPAR trafficking and function in hippocampal CA1 pyramidal neurons. However, its physiological roles in other types of neurons remain to be characterized. Here, we investigated the role of GSG1L in hippocampal dentate granule cells and found that GSG1L is important for the regulation of synaptic strength but is not critical for the modulation of AMPAR deactivation and desensitization kinetics. These data demonstrate a neuronal type-specific role of GSG1L and suggest that physiological function of AMPAR auxiliary subunits may vary in different types of neurons. NEW & NOTEWORTHY GSG1L is a newly identified AMPA receptor (AMPAR) auxiliary subunit and plays a unique role in the regulation of AMPAR trafficking and function in hippocampal CA1 pyramidal neurons. However, its role in the regulation of AMPARs in hippocampal dentate granule cells remains to be characterized. The current work reveals that GSG1L regulates strength of AMPAR-mediated synaptic transmission but not the receptor kinetic properties in hippocampal dentate granule neurons.

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Molecular Regulation of Microlymphatic Formation and Function: Role of Nitric Oxide

Trends in Cardiovascular Medicine ◽

10.1016/j.tcm.2005.06.003 ◽

2005 ◽

Vol 15 (5) ◽

pp. 169-173 ◽

Cited By ~ 15

Author(s):

Jeroen Hagendoorn ◽

Timothy P. Padera ◽

Dai Fukumura ◽

Rakesh K. Jain

Keyword(s):

Nitric Oxide ◽

Molecular Regulation ◽

And Function

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Copper deficiency and cardiovascular disease: role of peroxidation, glycation, and nitration

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y00-054 ◽

2000 ◽

Vol 78 (10) ◽

pp. 848-855 ◽

Cited By ~ 46

Author(s):

Jack T Saari

Keyword(s):

Nitric Oxide ◽

Blood Vessels ◽

Energy Use ◽

Copper Deficiency ◽

Structural Integrity ◽

Dietary Copper ◽

Cardiovascular Defects ◽

And Function ◽

Reduced Activity

Dietary copper deficiency causes a variety of cardiovascular deficits. Systemic effects include high blood pressure, enhancement of inflammation, anemia, reduced blood clotting, and possibly arteriosclerosis. Effects on specific organs or tissues include weakened structural integrity of the heart and blood vessels, impairment of energy use by the heart, reduced ability of the heart to contract, altered ability of blood vessels to control their diameter and grow, and altered structure and function of circulating blood cells. In some instances, the cause of a defect can be directly attributed to reduced activity of a specific copper-dependent enzyme. However, three nonspecific mechanisms of damage have been implicated in cardiovascular defects of copper deficiency. They are peroxidation, the interaction of oxygen-derived free radicals with lipids and proteins (possibly DNA); glycation, the nonenzymatic glycosylation of proteins; and nitration, the interaction of nitric oxide and its metabolites with peptides and proteins. Though independently these mechanisms present great potential for damage, the possibility that they may interact presents an added reason for concern. Furthermore, the fact that at least two of these mechanisms are associated with diabetes and aging suggests that copper deficiency may exacerbate deficits associated with these two conditions.Key words: copper, heart, circulation, peroxidation, glycation, nitric oxide.

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