scholarly journals Comparison of Basal Gene Expression and Induction of CYP3As in HepG2 and Human Fetal Liver Cells

2007 ◽  
Vol 30 (11) ◽  
pp. 2091-2097 ◽  
Author(s):  
Masataka Maruyama ◽  
Tamihide Matsunaga ◽  
Eri Harada ◽  
Shigeru Ohmori
1989 ◽  
Vol 83 (3) ◽  
pp. 1032-1038 ◽  
Author(s):  
T J Ley ◽  
K A Maloney ◽  
J I Gordon ◽  
A L Schwartz

2012 ◽  
Vol 27 (4) ◽  
pp. 398-404 ◽  
Author(s):  
Eiji Suzuki ◽  
Tamihide Matsunaga ◽  
Akiko Aonuma ◽  
Takamitsu Sasaki ◽  
Kiyoshi Nagata ◽  
...  

2012 ◽  
Vol 27 (6) ◽  
pp. 653-657 ◽  
Author(s):  
Tamihide Matsunaga ◽  
Masataka Maruyama ◽  
Tsutomu Matsubara ◽  
Kiyoshi Nagata ◽  
Yasushi Yamazoe ◽  
...  

Hepatology ◽  
2011 ◽  
Vol 54 (6) ◽  
pp. 1901-1912 ◽  
Author(s):  
Linda Andrus ◽  
Svetlana Marukian ◽  
Christopher T. Jones ◽  
Maria Teresa Catanese ◽  
Timothy P. Sheahan ◽  
...  

1977 ◽  
Vol 55 (5) ◽  
pp. 571-575 ◽  
Author(s):  
L. F. Congote ◽  
F. Bruno ◽  
S. Solomon

α-Fetoprotein and the synthesis of heme associated with hemoglobin were measured simultaneously in short-term cultures of human fetal liver cells to correlate the relationship of α-fetoprotein to erythroid cell function. Both synthetic processes decreased exponentially during the first 5 days of culture. The use of media supplemented with different batches of fetal calf serum and porcine portal vein serum indicated that the optimal conditions for the production of α-fetoprotein were different from those required for the synthesis of heme associated with hemoglobin. Moreover, the α-fetoprotein-producing cells could be separated from erythroid cells after velocity sedimentation in Ficoll gradients. Although it is well known that erythropoiesis and α-fetoprotein production occur simultaneously during ontogenesis, α-fetoprotein itself (0.01–100 μg/ml) did not stimulate heme synthesis in liver erythroid cells. Erythropoietin did not stimulate α-fetoprotein production. It is concluded that there is no cause–effect relationship between α-fetoprotein production and erythroid cell function in human fetal liver cells and that the two processes occur independently in different cell types.


2004 ◽  
Vol 199 (3) ◽  
pp. 97
Author(s):  
Anming Xiong ◽  
Eric Lagasse ◽  
Nobuko Uchida ◽  
Tim Austin ◽  
Stanley Tamaki ◽  
...  

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