primary monolayer culture
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Hepatology ◽  
2007 ◽  
Vol 2 (1) ◽  
pp. 13S-18S ◽  
Author(s):  
Scheffer C. G. Tseng ◽  
Philip C. Lee ◽  
Peter F. Ells ◽  
D. Montgomery Bissell ◽  
Edward A. Smuckler ◽  
...  

2006 ◽  
Vol 39 (1) ◽  
pp. 23-26
Author(s):  
Hyuk-Chu Kwon ◽  
Seong-Hee Choi ◽  
Eun-Hee Kim ◽  
Deug-Woo Han ◽  
Joon-Yeong Kwon

2003 ◽  
Vol 22 (12) ◽  
pp. 639-645 ◽  
Author(s):  
S A Tasaduq ◽  
K Singh ◽  
S Sethi ◽  
S C Sharma ◽  
K L Bedi ◽  
...  

HP-1 a herbal formulation comprising of Phyllanthus niruri and extracts of Terminalia belerica, Terminalia chebula, Phyllanthus emblica and Tinospora cordifoliahas been evaluated for hepatoprotective activity against carbon tetrachloride (CCl4) induced toxicity. Results show that HP-1 reversed the leakage of lactate dehydrogenase (LDH) and glutamate pyruvate transaminase (GPT) and prevented the depletion of glutathione (GSH) levels in a primary monolayer culture of rat hepatocytes (in vitro). HP-1 attenuated the serum toxicity as manifested in elevated levels of transaminases (glutamate oxaloacetate transaminase (GOT), and GPT) The anti-oxidative enzymes in liver (catalase and superoxide dismutase (SOD)) were restored to normal values after the oral administration of HP-1. HP-1 suppressed the formation of the superoxide anion radical and reduced CCl4 mediated lipid peroxidation (LPO). Silymarin and antioxidants (ascorbic acid,β-carotene and tocopherol) were used for comparison. The present study showed that HP-1 is a potential hepatoprotective formulation with an additional attribute of being anti-peroxidative.


1992 ◽  
Vol 270 (3) ◽  
pp. 513-519 ◽  
Author(s):  
S. Raczek ◽  
C. H. Yeung ◽  
L. Hertle ◽  
H. Schulze ◽  
T. G. Cooper

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