scholarly journals Synthetic approach to the synthesis of eudesmane type of sesquiterpenes by using furan derivatives as a starting material.

1976 ◽  
Vol 24 (6) ◽  
pp. 1354-1361 ◽  
Author(s):  
TETSUJI KAMETANI ◽  
HIDEO NEMOTO ◽  
MIE TAKEUCHI ◽  
SATOSHI HIBINO ◽  
KEIICHIRO FUKUMOTO
Keyword(s):  
Starting Material ◽  
Synthetic Approach ◽  
Furan Derivatives

scholarly journals A Newfangled Synthesis of Integrase Inhibitor Drug Substance Raltegravir Potassium

2019 ◽  
Vol 31 (11) ◽  
pp. 2618-2622
Author(s):  
S. Venkat Rao ◽  
Vamsi Krishna Potluri ◽  
Ramesh Babu Potluri
Keyword(s):  
Integrase Inhibitor ◽  
Starting Material ◽  
Drug Substance ◽  
Synthetic Approach ◽  
Carbonyl Chloride ◽  
Stability Issue ◽  
Inhibitor Drug ◽  
Almost All

Raltegravir sodium synthesis was achieved from its one of the key starting materials with retro synthetic approach, in which without using its critical starting material chemically known as 5-methyl-1,3,4-oxadiazole-2-carbonyl chloride and which is more unstable during the synthesis of raltegravir potassium. Almost all the existed literatures commonly using this starting material in its synthesis even it is having a stability issue and hence to achieve a stable and economically viable synthesis. The current research describes a new route of synthesis by constructing an oxadiazole ring in a retro synthetic manner.

An improved and practical synthesis of Fmoc Rink linker

2019 ◽  
Vol 43 (3-4) ◽  
pp. 81-85
Author(s):  
Ling-yan Qin ◽  
Hao-ting Zhu ◽  
Li Zhan ◽  
Yong Zhu ◽  
Yu Luo
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Scale Up ◽  
Starting Material ◽  
Synthetic Approach ◽  
Phase Synthesis ◽  
Practical Synthesis

Fmoc Rink linker is a widely used peptide-resin linker in the solid-phase synthesis of peptide-amides. This paper describes an improved and practical eight-step synthetic approach for this compound in a 50% overall yield, using p-hydroxybenzaldehyde as the starting material. The procedure is operationally simple and amenable to scale-up synthesis.

A novel synthetic approach to the ecdysone side chain via furan derivatives

1981 ◽  
Vol 22 (25) ◽  
pp. 2373-2374 ◽  
Author(s):  
Tetsuji Kametani ◽  
Masayoshi Tsubuki ◽  
Hideo Nemoto
Keyword(s):  
Side Chain ◽  
Synthetic Approach ◽  
Furan Derivatives

The chemistry of thujone. XX. New enantioselective syntheses of Ambrox and epi-Ambrox

1997 ◽  
Vol 75 (8) ◽  
pp. 1136-1150 ◽  
Author(s):  
James P. Kutney ◽  
Carles Cirera
Keyword(s):  
Starting Material ◽  
Synthetic Approach ◽  
Formal Synthesis ◽  
Red Cedar ◽  
Western Red Cedar ◽  
Enantioselective Syntheses ◽  
Chiral Synthon

The development of a new synthetic approach to (−)-Ambrox® (37) and epi-Ambrox® (29) using thujone (1) as a chiral synthon, is presented. Thujone (1), a readily available starting material obtained from Western red cedar, can be efficiently converted to β-cyperone (2) and the latter is then chemically elaborated to the key intermediate, the enone 6. A carbonyl transposition of 6 to enone 9 also allows a formal synthesis of (−)-Polywood® (18). Keywords: thujone, β-cyperone, (−)-Ambrox®, epi-Ambrox®, synthesis.

Enantioselective total synthesis of (+)-serinolamide A

RSC Advances ◽  
2015 ◽  
Vol 5 (51) ◽  
pp. 41013-41016 ◽  
Author(s):  
Suraksha Gahalawat ◽  
Satyendra Kumar Pandey
Keyword(s):  
Total Synthesis ◽  
Starting Material ◽  
Synthetic Approach ◽  
Enantioselective Total Synthesis ◽  
Highly Efficient

A short and highly efficient enantioselective synthetic approach to (+)-serinolamide A 1 from racemic butadiene monoepoxide as a starting material is described.

Synthesis and Characterization of meso-Tetraphenylporphyrin-Corrole Unsymmetrical Dyads

1998 ◽  
Vol 02 (06) ◽  
pp. 501-510 ◽  
Author(s):  
ROBERTO PAOLESSE ◽  
ANTONELLA MACAGNANO ◽  
DONATO MONTI ◽  
PIETRO TAGLIATESTA ◽  
TRISTANO BOSCHI
Keyword(s):  
Starting Material ◽  
Synthesis And Characterization ◽  
Synthetic Approach ◽  
Formyl Group ◽  
Stepwise Approach ◽  
Biomimetic Models ◽  
Photochemical Processes

Flat and gable meso-tetraphenylporphyrin-corrole heterodimers have been synthesized following a stepwise approach. The macrocyclic precursor for both isomers is a functionalized meso-tetraphenylporphyrin (TPP) bearing a formyl group at one of the peripheral phenyl groups. The preparation of these starting materials has been improved with respect to the previously reported method. Acidic condensation with pyrrole 8 allows the preparation of a TPP-dipyrromethane intermediate. Subsequent decarboxylation followed by reaction with formylpyrrole 2 affords the corresponding TPP–a,c-biladiene species. Final cyclization of this intermediate affords the desired heterodimer. Attempts to use the functionalized corrole 5 as starting material were unsuccessful, as this corrole failed to condense with pyrrole and benzaldehyde. This synthetic approach provides new examples of tetrapyrrolic heterodimers, which can represent useful biomimetic models to study photochemical processes.

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