Determination of the stability constants for inclusion complexes of cyclodextrins with various drug molecules by high performance liquid chromatography.

Amoxicillin, substance-related to semisynthetic penicillin, has been widely used to treat infections caused by various microorganisms, however reports of suitable methods for the quantitative determination and indicative of the stability of formulations containing this substance are rare. Due to lack of studies on the forced degradation of the substance and on the need to monitor the quality of this type of formulation was proposed and validated a method for the determination of amoxicillin content in capsules by high-performance liquid chromatography - HPLC for the quality control of amoxicillin capsules, allowing the provision of useful information about the characteristics of this type of formulation and its stability. The method was validated for parameters of linearity, specificity, accuracy, precision, and robustness

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THE NEW METHOD FOR DETERMINATION OF THE STABILITY CONSTANTS OF CYCLODEXTRIN–PROSTAGLANDIN INCLUSION COMPLEXES BY LIQUID CHROMATOGRAPHY

Chemistry Letters ◽

10.1246/cl.1978.661 ◽

1978 ◽

Vol 7 (7) ◽

pp. 661-664 ◽

Cited By ~ 21

Author(s):

Kaneto Uekama ◽

Fumitoshi Hirayama ◽

Tetsumi Irie

Keyword(s):

Liquid Chromatography ◽

Inclusion Complexes ◽

Stability Constants ◽

New Method ◽

The Stability

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High-performance liquid chromatography with ion pairing and electrochemical detection for the determination of the stability of two forms of vitamin C

Journal of Chromatography A ◽

10.1016/0021-9673(93)80030-c ◽

1993 ◽

Vol 632 (1-2) ◽

pp. 91-96 ◽

Cited By ~ 3

Author(s):

Kathryn M. De Antonis ◽

Phyllis R. Brown ◽

Zhen Yi ◽

Paul D. Maugle

Keyword(s):

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Vitamin C ◽

Electrochemical Detection ◽

High Performance ◽

Ion Pairing ◽

The Stability

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Development and Validation of a High-performance Liquid Chromatography Method with Ultraviolet Detection for the Determination of Flunitrazepam in Human Plasma

Revista de Chimie ◽

10.37358/rc.08.12.2047 ◽

2009 ◽

Vol 59 (12) ◽

Author(s):

Bela Kiss ◽

Daniela-Saveta Popa ◽

Marius Bojita ◽

Felicia Loghin

Keyword(s):

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Human Plasma ◽

High Performance ◽

Hplc Method ◽

Simple Liquid ◽

Chromatography Method ◽

Liquid Chromatography Method ◽

The Stability

A high performance liquid chromatography (HPLC) method was developed and validated for determination of flunitrazepam in human plasma. After a simple liquid-liquid extraction, the analyses were carried out on a ODS column with diode array detection at 330nm. The mobile phase consisted in a mixture of potassium dihydrogene phosphate/acetonitrile (40/60, v/v). The method showed good linearity, accuracy and precision. Advantages of this validated assay include a simple plasma extraction method, short analysis time and good sensitivity (LLOQ = 5ng/mL). The stability data indicated a potential instability of flunitrazepam in plasma at room temperature.

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