scholarly journals The inhibitory effect of 3,3',4,5'-tetrahydroxystilbene, a constituent of Cassia garrettiana, on anti-IgE-induced histamine release from human basophils in vitro.

1991 ◽  
Vol 39 (3) ◽  
pp. 805-807 ◽  
Author(s):  
Yoshihiko INAMORI ◽  
Masafumi OGAWA ◽  
Hiroshi TSUJIBO ◽  
Kimiye BABA ◽  
Mitsugi KOZAWA ◽  
...  
Keyword(s):  
Histamine Release ◽  
Inhibitory Effect ◽  
Human Basophils

scholarly journals Selective inhibition by antiflamrnin-2 of thromboxane B2release from isolated and perfused guinea-pig lung

1992 ◽  
Vol 1 (4) ◽  
pp. 251-254
Author(s):  
Lidia Sautebin ◽  
Giuseppe Cirino ◽  
Massimo Di Rosa
Keyword(s):  
Guinea Pig ◽  
Histamine Release ◽  
Calcium Ionophore ◽  
Selective Inhibition ◽  
Inhibitory Effect ◽  
Amino Acid Residues ◽  
A 23187 ◽  
Normal Lungs

Antiflammin-2 (AF2) is a nonapeptide corresponding to the amino acid residues 246–254 of lipocortin-1 showing anti-inflammatory activity both in vitro and in vivo. The effect of AF2 on the thromboxane B2(TXB2) and histamine release from isolated and perfused guinea-pig lungs has been studied. AF-2 (10–100 nM) inhibited leukotriene C4- (LTC4) (3 ng) and antigen-induced (ovalbumin, 1 mg) TXB2release in normal and sensitized lungs, respectively. In contrast AF-2 (100 nM) did not modify TXB2release induced by histamine (5 μg) or bradykinin (5 μg) in normal lungs. Antigen-induced histamine release was not affected by 100 nM AF-2 infusion. When tested in chopped lung fragments AF-2 (0.1–25 μM) did not modify the release of histamine and TXB2induced by antigen (ovalbumin, 10 μg ml−1) or calcium ionophore A 23187 (1 μM). Our results show that the inhibitory effect of AF-2 on TXB2release is selective and depends on the stimulus applied. In this respect AF-2 mimics, at least in part, the actions of both glucocorticoids and lipocortin-1.

Inhibition of histamine release from human basophils in vitro by calmodulin antagonists

1983 ◽  
Vol 28 (3) ◽  
pp. 334-340 ◽  
Author(s):  
Gianni Marone ◽  
Michele Columbo ◽  
Sergio Poto ◽  
Mario Condorelli
Keyword(s):  
Histamine Release ◽  
Calmodulin Antagonists ◽  
Human Basophils
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