scholarly journals Enhancing Effect of N-Acetyl-L-cysteine or 2-Mercaptoethanol on the in Vitro Permeation of 5-Fluorouracil or Tolnaftate through the Human Nail Plate.

1998 ◽  
Vol 46 (11) ◽  
pp. 1797-1802 ◽  
Author(s):  
Yoichi KOBAYASHI ◽  
Misao MIYAMOTO ◽  
Kenji SUGIBAYASHI ◽  
Yasunori MORIMOTO
Keyword(s):  
Nail Plate ◽  
Enhancing Effect ◽  
Human Nail ◽  
In Vitro Permeation

In vitro permeation of several drugs through the human nail plate: relationship between physicochemical properties and nail permeability of drugs

2004 ◽  
Vol 21 (4) ◽  
pp. 471-477 ◽  
Author(s):  
Yoichi Kobayashi ◽  
Tsunehisa Komatsu ◽  
Machiko Sumi ◽  
Sachihiko Numajiri ◽  
Misao Miyamoto ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Nail Plate ◽  
Human Nail ◽  
In Vitro Permeation

In Vitro Penetration of a Novel Oxaborole Antifungal (AN2690) Into the Human Nail Plate

2007 ◽  
Vol 96 (10) ◽  
pp. 2622-2631 ◽  
Author(s):  
Xiaoying Hui ◽  
Stephen J. Baker ◽  
Ronald C. Wester ◽  
Sherry Barbadillo ◽  
Anne K. Cashmore ◽  
...  
Keyword(s):  
Nail Plate ◽  
Human Nail

In vitro permeation of desmopressin across rabbit nasal mucosa from liquid nasal sprays: The enhancing effect of potassium sorbate

2009 ◽  
Vol 37 (1) ◽  
pp. 36-42 ◽  
Author(s):  
Bortolotti Fabrizio ◽  
Balducci Anna Giulia ◽  
Sonvico Fabio ◽  
Russo Paola ◽  
Colombo Gaia
Keyword(s):  
Nasal Mucosa ◽  
Potassium Sorbate ◽  
Enhancing Effect ◽  
Nasal Sprays ◽  
In Vitro Permeation

Enhancing effect of alpha-hydroxyacids on “in vitro” permeation across the human skin of compounds with different lipophilicity

2006 ◽  
Vol 314 (1) ◽  
pp. 31-36 ◽  
Author(s):  
A. Copoví ◽  
O. Díez-Sales ◽  
J.V. Herráez-Domínguez ◽  
M. Herráez-Domínguez
Keyword(s):  
Human Skin ◽  
Enhancing Effect ◽  
In Vitro Permeation

scholarly journals A Preliminary Investigation of Additive Manufacture to Fabricate Human Nail Plate Surrogates for Pharmaceutical Testing

Pharmaceutics ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 250
Author(s):  
Bruno C. Sil ◽  
Avnish Patel ◽  
Jonathan M. Crowther ◽  
David J. Moore ◽  
Jonathan Hadgraft ◽  
...  
Keyword(s):  
Preliminary Investigation ◽  
Nail Plate ◽  
Additive Manufacture ◽  
Human Nail ◽  
Ongoing Work ◽  
Permeation Studies ◽  
3D Printed ◽  
Design And Manufacture ◽  
Physical And Chemical

In vitro permeation studies using nail clippings or nail plates are commonly used in the development of transungual formulations. However, there are ethical, safety and cost issues associated with sourcing such tissues. Herein, we describe a preliminary approach is described for the design and manufacture of a human nail model surrogate based on 3D printing. To evaluate these 3D printed constructs, nails were mounted in conventional glass Franz cells and a commercial antifungal lacquer formulation containing ciclopirox olamine was applied daily to the surrogate printed surfaces for a period of 14 days. On days 8 and 14, the surfaces of the 3D printed nails were washed with ethanol to remove excess formulation. Confocal Raman spectroscopy (CRS) was used to profile the drug in the 3D printed nail. At the end of the Franz cell studies, no drug was observed in the receptor phase. CRS studies confirmed penetration of the active into the model nails with reproducible depth profiles. Our ongoing work is focused on synthesising commercial and non-commercial printable resins that can replicate the physical and chemical characteristics of the human nail. This will allow further evaluation of actives for ungual therapy and advance the development of the surrogate nail tissue model.

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