enhancing effect
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2022 ◽  
Vol 374 ◽  
pp. 131776
Author(s):  
Binbin Yu ◽  
Wei Wu ◽  
Bei Wang ◽  
Na Zhang ◽  
Kathrine H. Bak ◽  
...  
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2022 ◽  
Vol 2022 ◽  
pp. 1-7
Author(s):  
Yiren Wang ◽  
Ruilin Wu

Fasting is a prevalent approach to weight loss and is a feasible method for treating some diseases, such as type 2 diabetes. Meanwhile, the effects of intermittent fasting on health, aging, and disease process are hot issues and are of concern by researchers of multiple areas, even the public. This article introduces the effects of fasting on human lipid metabolism, glucose metabolism, protein metabolism, and neuroendocrine metabolism; demonstrates the metabolic conversion caused by fasting; and describes the effects of fasting on human psychological health, the relationship between mood regulation and glucose, and the emotional enhancing effect induced by fasting.


RSC Advances ◽  
2022 ◽  
Vol 12 (4) ◽  
pp. 2287-2291
Author(s):  
Hanan Althikrallah ◽  
Elena F. Kozhevnikova ◽  
Ivan V. Kozhevnikov

Addition of gold to the Pt–CsPW catalyst has an enhancing effect on the HDO of DMTHF, with a twofold increase of turnover rate at Pt sites.


2021 ◽  
Vol 28 ◽  
pp. 100906
Author(s):  
Wenmin Zhao ◽  
Rui Bao ◽  
Jianhong Yi ◽  
Yi Zhang ◽  
Youfu Pu ◽  
...  

Author(s):  
Tamas Kriska ◽  
Anja Herrnreiter ◽  
Sandra L. Pfister ◽  
Adeniyi Adebesin ◽  
John R. Falck ◽  
...  

12/15-LO (12/15-lipoxygenase), encoded by Alox15 gene, metabolizes arachidonic acid to 12(S)-HETE (12-HETE). Macrophages are the major source of 12/15-LO among immune cells, and 12/15-LO plays a crucial role in development of hypertension. Global Alox15- or macrophage-deficient mice are resistant to Ang II (angiotensin II)–induced hypertension. This study tests the hypothesis that macrophage 12(S)-HETE contributes to Ang II–mediated arterial constriction and thus to development of Ang II–induced hypertension. Ang II constricted isolated abdominal aortic and mesenteric arterial rings. 12(S)-HETE (100 nmol/L) alone was without effect; however, it significantly enhanced Ang II–induced constriction. The presence of wild-type macrophages also enhanced the Ang II–induced constriction, while Alox15 −/− macrophages did not. Using this model, pretreatment of aortic rings with inhibitors, receptor agonists/antagonists, or removal of the endothelium, systematically uncovered an endothelium-mediated, Ang II receptor-2–mediated and superoxide-mediated enhancing effect of 12(S)-HETE on Ang II constrictions. The role of superoxide was confirmed using aortas from p47 phox−/− mice where 12(S)-HETE failed to enhance constriction to Ang II. In cultured arterial endothelial cells, 12(S)-HETE increased the production of superoxide, and 12(S)-HETE or Ang II increased the production of an isothromboxane-like metabolite. A TP (thromboxane receptor) antagonist inhibited 12(S)-HETE enhancement of Ang II constriction. Both Ang II–induced hypertension and the enhancing effect of 12(S)-HETE on Ang II contractions were eliminated by a BLT2 (leukotriene B 4 receptor-2) antagonist. These results outline a mechanism where the macrophage 12/15-LO pathway enhances the action of Ang II. 12(S)-HETE, acting on the BLT2, contributes to the hypertensive action of Ang II in part by promoting endothelial synthesis of a superoxide-derived TP agonist.


Fuel ◽  
2021 ◽  
pp. 122606
Author(s):  
Hongyu Guo ◽  
Shangwei Shi ◽  
Guofu Li ◽  
Changjiang Ji ◽  
Chaoyong Fu ◽  
...  

2021 ◽  
Vol 53 ◽  
pp. 101740
Author(s):  
Simona Renda ◽  
Christian Di Stasi ◽  
Joan J. Manyà ◽  
Vincenzo Palma

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