scholarly journals Design, Synthesis and Discovery of 1-(2-(6-Chloro-3-methylsulfonyl)-naphthyl)-1H-pyrazole-5-carboxylamides as Highly Potent Factor Xa Inhibitors

2009 ◽  
Vol 57 (9) ◽  
pp. 1004-1007 ◽  
Author(s):  
Zhaozhong Jon Jia ◽  
Robert Murry Scarborough ◽  
Penglie Zhang ◽  
Sherin Halfon ◽  
Ann Elizabeth Arfsten ◽  
...  
Keyword(s):  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Design Synthesis ◽  
Potent Factor

ChemInform Abstract: Design, Synthesis and Discovery of 1-(2-(6-Chloro-3-methylsulfonyl)-naphthyl)-1H-pyrazole-5-carboxylamides as Highly Potent Factor Xa Inhibitors.

ChemInform ◽  
2010 ◽  
Vol 41 (8) ◽  
Author(s):  
Zhaozhong Jon Jia ◽  
Robert Murry Scarborough ◽  
Penglie Zhang ◽  
Sherin Halfon ◽  
Ann Elizabeth Arfsten ◽  
...  
Keyword(s):  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Design Synthesis ◽  
Potent Factor

Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: Exploration of 6–6 fused rings as alternative S1 moieties

2009 ◽  
Vol 17 (24) ◽  
pp. 8221-8233 ◽  
Author(s):  
Kenji Yoshikawa ◽  
Shozo Kobayashi ◽  
Yumi Nakamoto ◽  
Noriyasu Haginoya ◽  
Satoshi Komoriya ◽  
...  
Keyword(s):  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Design Synthesis ◽  
Potent Factor

Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: Exploration of 5–6 fused rings as alternative S1 moieties

2009 ◽  
Vol 17 (24) ◽  
pp. 8206-8220 ◽  
Author(s):  
Kenji Yoshikawa ◽  
Aki Yokomizo ◽  
Hiroyuki Naito ◽  
Noriyasu Haginoya ◽  
Shozo Kobayashi ◽  
...  
Keyword(s):  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Design Synthesis ◽  
Potent Factor

Design, Synthesis, and SAR of Amino Acid Derivatives as Factor Xa Inhibitors

2001 ◽  
Vol 11 (22) ◽  
pp. 2947-2950 ◽  
Author(s):  
Ting Su ◽  
Yanhong Wu ◽  
Brandon Doughan ◽  
Zhaozhong J. Jia ◽  
John Woolfrey ◽  
...  
Keyword(s):  
Amino Acid ◽  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Amino Acid Derivatives ◽  
Design Synthesis

Design, synthesis, and in vitro biological activity of benzimidazole based factor Xa inhibitors

2000 ◽  
Vol 10 (9) ◽  
pp. 963-966 ◽  
Author(s):  
Zuchun (Spring) Zhao ◽  
Damian O Arnaiz ◽  
Brian Griedel ◽  
Steven Sakata ◽  
Jerry L Dallas ◽  
...  
Keyword(s):  
Biological Activity ◽  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Design Synthesis

Design, Synthesis, and Biological Evaluation of Potent and Selective Amidino Bicyclic Factor Xa Inhibitors

2000 ◽  
Vol 43 (23) ◽  
pp. 4398-4415 ◽  
Author(s):  
Qi Han ◽  
Celia Dominguez ◽  
Pieter F. W. Stouten ◽  
Jeongsook M. Park ◽  
Daniel E. Duffy ◽  
...  
Keyword(s):  
Factor Xa ◽  
Biological Evaluation ◽  
Factor Xa Inhibitors ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation
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