scholarly journals Chemical Studies on Crude Drug Processing. X. On the Constituents of Rehmanniae Radix (4) : Comparison of the Constituents of Various Rehmanniae Radixes Originating in China, Korea, and Japan

1995 ◽  
Vol 115 (12) ◽  
pp. 992-1003 ◽  
Author(s):  
Isao KITAGAWA ◽  
Youichi FUKUDA ◽  
Toshio TANIYAMA ◽  
Masayuki YOSHIKAWA
1984 ◽  
Vol 104 (8) ◽  
pp. 848-857 ◽  
Author(s):  
ISAO KITAGAWA ◽  
ZHAOLONG CHEN ◽  
MINORU YOSHIHARA ◽  
MASAYUKI YOSHIKAWA

1983 ◽  
Vol 31 (8) ◽  
pp. 2712-2717 ◽  
Author(s):  
MITSUGI KOZAWA ◽  
MASAYO FUKUMOTO ◽  
YOUKO MATSUYAMA ◽  
KIMIYE BABA
Keyword(s):  

2004 ◽  
Vol 32 (06) ◽  
pp. 829-839 ◽  
Author(s):  
Takako Yokozawa ◽  
Hyun Young Kim ◽  
Noriko Yamabe

The effects of dried Rehmanniae Radix (Di Huang) extract were investigated using a diabetic nephropathy model: rats given streptozotocin after nephrectomy. The results showed that this crude drug reduced the magnitudes of the increases in glucose, urea nitrogen, 5-hydroxymethylfurfural and thiobarbituric acid (TBA)-reactive substance levels, with the effects being most marked in the high blood glucose group. The renal histopathological lesions, which were conspicuous in rats not given dried Rehmanniae Radix extract, were ameliorated considerably in the high blood glucose group given this extract. It appears that dried Rehmanniae Radix extract may be useful as a therapeutic agent for inhibiting the progression of diabetic nephropathy. On the basis of these results, the possible mechanisms of action of this crude drug are discussed.


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