scholarly journals Chemical Studies on Crude Drug Processing. VIII. On the Constituents of Rehmanniae Radix. (2): Absolute Stereostructures of Rehmaglutin C and Glutinoside Isolated from Chinese Rehmanniae Radix, the Dried Root of Rehmannia glutinosa Libosch.

1995 ◽  
Vol 43 (7) ◽  
pp. 1096-1100 ◽  
Author(s):  
Isao KITAGAWA ◽  
Youichi FUKUDA ◽  
Toshio TANIYAMA ◽  
Masayuki YOSHIKAWA
Keyword(s):  
Rehmannia Glutinosa ◽  
Crude Drug ◽  
Chemical Studies ◽  
Rehmanniae Radix ◽  
Rehmannia Glutinosa Libosch

scholarly journals Improvement of the Field Productivity in Rehmannia glutinosa Libosch. Crops by Application of N, P and K Fertilizers and Plant Spacing

2020 ◽  
Vol 19 (3) ◽  
pp. 214-222
Author(s):  
Thanh Loan Pham ◽  
Van Huy Nguyen ◽  
Thi Le Thu Hoang ◽  
Thi Tam Tien Ha ◽  
Chi Nghia Phan ◽  
...  
Keyword(s):  
Plant Spacing ◽  
Rehmannia Glutinosa ◽  
Rehmannia Glutinosa Libosch

scholarly journals Rehmannia glutinosa Libosch Extracts Prevent Bone Loss and Architectural Deterioration and Enhance Osteoblastic Bone Formation by Regulating the IGF-1/PI3K/mTOR Pathway in Streptozotocin-Induced Diabetic Rats

2019 ◽  
Vol 20 (16) ◽  
pp. 3964 ◽  
Author(s):  
Wan Gong ◽  
Naidan Zhang ◽  
Gang Cheng ◽  
Quanlong Zhang ◽  
Yuqiong He ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bone Formation ◽  
Signaling Pathways ◽  
Bone Microarchitecture ◽  
Diabetic Rats ◽  
Mtor Pathway ◽  
Mtor Signaling ◽  
Rehmannia Glutinosa ◽  
Mineral Density ◽  
Rehmannia Glutinosa Libosch

Rehmanniae Radix Praeparata (RR, named as Shudihuang in traditional Chinese medicine), the steamed roots of Rehmannia glutinosa Libosch (Scrophulariaceae), has been demonstrated to have anti-diabetic and anti-osteoporotic activities. This study aimed to explore the protective effect and underlying mechanism of RR on diabetes-induced bone loss. It was found that RR regulated the alkaline phosphatase activity and osteocalcin level, enhanced bone mineral density, and improved the bone microarchitecture in diabetic rats. The catalpol (CAT), acteoside (ACT), and echinacoside (ECH) from RR increased the proliferation and differentiation of osteoblastic MC3T3-E1 cells injured by high glucose and promoted the production of IGF-1 and expression of related proteins in BMP and IGF-1/PI3K/mammalian target of rapamycin complex 1 (mTOR) signaling pathways. The verifying tests of inhibitors of BMP pathway (noggin) and IGF-1/PI3K/mTOR pathway (picropodophyllin) and molecular docking of IGF-1R further indicated that CAT, ACT, and ECH extracted from RR enhanced bone formation by regulating IGF-1/PI3K/mTOR signaling pathways. These findings suggest that RR may prove to be a promising candidate drug for the prevention and treatment of diabetes-induced osteoporosis.

scholarly journals Chemical Studies on Crude Drug Processing. II. Aconiti Tuber (1). : On the Constituents of "Chuan-wu", the Dried Tuber of Aconitum carmichaeli DEBX.

1984 ◽  
Vol 104 (8) ◽  
pp. 848-857 ◽  
Author(s):  
ISAO KITAGAWA ◽  
ZHAOLONG CHEN ◽  
MINORU YOSHIHARA ◽  
MASAYUKI YOSHIKAWA
Keyword(s):  
Crude Drug ◽  
Chemical Studies ◽  
Aconitum Carmichaeli
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