scholarly journals Synthesis of the Furan Derivatives. XLIX. : Wittig Reaction of Organosulfurphosphoranes with Some Aromatic Aldehydes

1969 ◽  
Vol 89 (10) ◽  
pp. 1446-1456 ◽  
Author(s):  
HARUO SAIKACHI ◽  
SHUZO NAKAMURA
Keyword(s):  
Wittig Reaction ◽  
Aromatic Aldehydes ◽  
Furan Derivatives

scholarly journals Synthesis of the Furan Derivatives. XXXV : Stereospecification of Wittig Reaction

1968 ◽  
Vol 88 (1) ◽  
pp. 110-115 ◽  
Author(s):  
HARUO SAIKACHI ◽  
SHUZO NAKAMURA
Keyword(s):  
Wittig Reaction ◽  
Furan Derivatives

The Wittig Reaction of 2-t-Butoxycarbonyl-1-methoxycarbonylethylidenetriphenylphosphorane: A Surrogate for the Stobbe Reaction

1987 ◽  
Vol 40 (10) ◽  
pp. 1737 ◽  
Author(s):  
MA Rizzacasa ◽  
MV Sargent
Keyword(s):  
Wittig Reaction ◽  
Aromatic Aldehydes ◽  
High Yield

The reaction of 2-t-butoxycarbonyl-l-methoxycarbonylethylidenetriphenylphosphorane (3) with a range of aromatic aldehydes has been explored. The resultant itaconic esters, obtained in high yield, are readily converted into methyl 4-acetoxynaphthalene-2-carboxylates.

scholarly journals Synthesis and Antitumor Activity of Novel Pyridoxine-Based Bioisosteric Analogs of trans-Stilbenes

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Mikhail V. Pugachev ◽  
Thang T. N. Nguyen ◽  
Timur M. Bulatov ◽  
Roman S. Pavelyev ◽  
Alfia G. Iksanova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Anticancer Agents ◽  
Breast Cancer Cells ◽  
Wittig Reaction ◽  
Cancer Cell Line ◽  
Aromatic Aldehydes ◽  
Blue Fluorescence ◽  
Starting Point ◽  
Estrogen Receptor Negative ◽  
Mcf 7

A series of trans-6-phenylethenyl substituted pyridoxine derivatives, novel bioisosteric analogs of drugs based on trans-stilbene scaffold, were synthesized using the Wittig reaction of a bis-triphenylphosphonium pyridoxine derivative with various aromatic aldehydes. Two compounds demonstrated high activity against the estrogen-dependent MCF-7 (breast cancer) cell line with IC50 in the range of 1.9–7.9 µM and very good selectivity for other studied normal and tumor cells, including the estrogen receptor negative MDA-MB-231 breast cancer cells. The active compounds possessed an intense blue fluorescence, and this feature allowed us to effectively visualize them in cytoplasm and in nucleus. The obtained results make the described chemotype a promising starting point for the development of new anticancer agents for the therapy of estrogen-dependent malignancies.

A modular olefination reaction between aldehydes and diborylsilylmethide lithium salts

2021 ◽  
Author(s):  
Elena Fernandez ◽  
Oriol Salvado
Keyword(s):  
Wittig Reaction ◽  
Aromatic Aldehydes ◽  
Lithium Salts ◽  
Unsaturated Aldehydes ◽  
Trisubstituted Alkenes

We describe the preparation of densely functionalised 1,1,-silylborylated trisubstituted alkenes, via boron-Wittig reaction, between LiC(Bpin)2(SiMe3) and aliphatic or aromatic aldehydes. The condensation of diborylsilylmethide lithium salts with α,β-unsaturated aldehydes provides...

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