scholarly journals EFFECTS OF CHRONIC TREATMENT WITH CAPTOPRIL(SQ 14,225), AN ORALLY ACTIVE INHIBITOR OFANGIOTENSIN I-CONVERTING ENZYME, INSPONTANEOUSLY HYPERTENSIVE RATS

1979 ◽  
Vol 29 (2) ◽  
pp. 285-294 ◽  
Author(s):  
Michael J. ANTONACCIO ◽  
Bernard RUBIN ◽  
Zola P. HOROVITZ ◽  
Robert J. LAFFAN ◽  
Morton E. GOLDBERG ◽  
...  
Keyword(s):  
Chronic Treatment ◽  
Converting Enzyme ◽  
Hypertensive Rats ◽  
Active Inhibitor ◽  
Orally Active

EFFECT OF INHIBITION OF CONVERTING ENZYME ON INACTIVE RENIN IN THE CIRCULATION OF SALT-REPLETE AND SALT-DEPLETE NORMAL SUBJECTS

1980 ◽  
Vol 86 (2) ◽  
pp. 329-335 ◽  
Author(s):  
J. A. MILLAR ◽  
M. T. HAMMAT ◽  
C. I. JOHNSTON
Keyword(s):  
Angiotensin Ii ◽  
Normal Subjects ◽  
Inhibitory Influence ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Active Inhibitor ◽  
Active Renin ◽  
Angiotensin I Converting Enzyme ◽  
Inactive Renin ◽  
Orally Active

Angiotensin II exerts an inhibitory influence on active renin release from the kidney. To assess a possible role for angiotensin II in the release of inactive renin, levels in the circulation were measured before and at regular intervals after the administration of captopril, an orally active inhibitor of angiotensin I-converting enzyme, to 12 salt-replete and six salt-deplete normal subjects. Concurrent measurements of active renin, angiotensin I and angiotensin II were also performed. Basal inactive renin in the salt-deplete group was increased compared with the salt-replete subjects, but inactive renin remained constant in both groups after treatment with captopril. There were significant increases in concentrations of both active renin and angiotensin I after treatment with captopril in all subjects and corresponding decreases in angiotensin II. These results suggested that angiotensin II does not influence the release of inactive renin, in contrast with its role in the release of active renin.

A SPECIFIC ORALLY ACTIVE INHIBITOR OF ANGIOTENSIN-CONVERTING ENZYME IN MAN

The Lancet ◽  
1977 ◽  
Vol 309 (8015) ◽  
pp. 775-778 ◽  
Author(s):  
RogerK Ferguson ◽  
HansR Brunner ◽  
GustaveA Turini ◽  
Haralambos Gavras ◽  
DorisN Mckinstry
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
Active Inhibitor ◽  
Orally Active

Ceranapril (SQ 29,852), an Orally Active Inhibitor of Angiotensin Converting Enzyme (ACE)

1990 ◽  
Vol 16 (1) ◽  
pp. 121-127 ◽  
Author(s):  
Jack M. DeForrest ◽  
Thomas L. Waldron ◽  
Charlotte Harvey ◽  
Robert Scalese ◽  
Susan Hammerstone ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
Active Inhibitor ◽  
Orally Active
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