scholarly journals Antagonistic Interaction Between BIIE 0246, a Neuropeptide Y Y2-Receptor Antagonist, and ωy-Conotoxin GVIA, a Ca2+ Channel Antagonist, in Presynaptic Transmitter Releases in Dog Splenic Arteries

2002 ◽  
Vol 89 (2) ◽  
pp. 188-191 ◽  
Author(s):  
Xiao-Ping Yang ◽  
Shigetoshi Chiba
Keyword(s):  
Neuropeptide Y ◽  
Receptor Antagonist ◽  
Antagonistic Interaction ◽  
Y2 Receptor

Characterization of the Brain Penetrant Neuropeptide Y Y2 Receptor Antagonist SF-11

2019 ◽  
Vol 10 (8) ◽  
pp. 3454-3463 ◽  
Author(s):  
Helena Domin ◽  
Natalia Piergies ◽  
Ewa Pięta ◽  
Elżbieta Wyska ◽  
Bartłomiej Pochwat ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Receptor Antagonist ◽  
Y2 Receptor ◽  
The Brain

scholarly journals BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y2 receptor antagonist

2000 ◽  
Vol 129 (6) ◽  
pp. 1075-1088 ◽  
Author(s):  
Yvan Dumont ◽  
Alain Cadieux ◽  
Henri Doods ◽  
Leng Hong Pheng ◽  
Roger Abounader ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Receptor Antagonist ◽  
Y2 Receptor

scholarly journals Neuropeptide Y reduces expression of social fear via simultaneous activation of Y1 and Y2 receptors

2019 ◽  
Vol 33 (12) ◽  
pp. 1533-1539 ◽  
Author(s):  
Johannes Kornhuber ◽  
Iulia Zoicas
Keyword(s):  
Neuropeptide Y ◽  
Receptor Antagonist ◽  
Social Experience ◽  
Fear Extinction ◽  
Dependent Manner ◽  
Contextual Fear ◽  
Y1 Receptor ◽  
Y2 Receptor ◽  
Social Fear ◽  
Simultaneous Activation

Background: Neuropeptide Y (NPY) has anxiolytic effects and facilitates extinction of cued and contextual fear in rodents, thereby acting as a resilience factor against exaggerated fear responses after adverse events. We investigated whether NPY influences acquisition, expression and extinction of social fear in a mouse model of social fear conditioning (SFC). Methods: NPY was administered intracerebroventricularly before SFC or before social fear extinction with or without prior administration of Y1 and/or Y2 receptor antagonists. Results: We show that NPY affects SFC-induced social fear in a time point–dependent manner. When administered before SFC, NPY did not affect acquisition, expression and extinction of social fear. However, when administered before social fear extinction, NPY reduced expression of social fear via simultaneous activation of Y1 and Y2 receptors. As such, neither the Y1 receptor antagonist BIBO3304 trifluoroacetate nor the Y2 receptor antagonist BIIE0246 was able to block the effects of NPY completely. However, when administered in combination, they completely blocked the effects of NPY on social fear expression. Conclusions: These findings have important clinical implications, as they suggest that although medication strategies aimed at increasing brain NPY activity are unlikely to prevent the formation of aversive memories after a traumatic social experience, they might improve the recovery from a traumatic social experience by reducing the expression of social fear.

BIIE0246: A selective and high affinity neuropeptide Y Y2 receptor antagonist

1999 ◽  
Vol 384 (2-3) ◽  
pp. R3-R5 ◽  
Author(s):  
Henri Doods ◽  
Wolfram Gaida ◽  
Heike A Wieland ◽  
Horst Dollinger ◽  
Gerd Schnorrenberg ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Receptor Antagonist ◽  
High Affinity ◽  
Y2 Receptor

Anxiolytic-like effect of the selective Neuropeptide Y Y2 receptor antagonist BIIE0246 in the elevated plus-maze

Peptides ◽  
2006 ◽  
Vol 27 (12) ◽  
pp. 3202-3207 ◽  
Author(s):  
Fabrizio Bacchi ◽  
Aleksander A. Mathé ◽  
Patricia Jiménez ◽  
Luigi Stasi ◽  
Roberto Arban ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Receptor Antagonist ◽  
Elevated Plus Maze ◽  
Y2 Receptor ◽  
Plus Maze
Sign in / Sign up

Export Citation Format

Share Document