Effects of Synthetic Sphingosine-1-Phosphate Analogs on Cytosolic Phospholipase A2α–Independent Release of Arachidonic Acid and Cell Toxicity in L929 Fibrosarcoma Cells: the Structure–Activity Relationship

Activity Relationship ◽

Cell Toxicity ◽

Cytosolic Phospholipase ◽

Structure Activity ◽

Fibrosarcoma Cells ◽

Sphingosine 1 Phosphate ◽

Structure–activity relationship studies of 3-dodecanoylindole-2-carboxylic acid inhibitors of cytosolic phospholipase A2α-mediated arachidonic acid release in intact platelets: variation of the keto moiety

Journal of Enzyme Inhibition and Medicinal Chemistry ◽

10.1080/14756360500228338 ◽

2005 ◽

Vol 20 (5) ◽

pp. 429-437 ◽

Cited By ~ 2

Author(s):

Afshin Ghasemi ◽

Alwine Schulze Elfringhoff ◽

Matthias Lehr

Keyword(s):

Arachidonic Acid ◽

Carboxylic Acid ◽

Activity Relationship ◽

Arachidonic Acid Release ◽

Cytosolic Phospholipase ◽

Structure Activity ◽

Acid Release ◽

Structure—Activity Relationship Studies of 1-Substituted 3-Dodecanoylindole-2-carboxylic Acids as Inhibitors of Cytosolic Phospholipase A2-Mediated Arachidonic Acid Release in Intact Platelets.

ChemInform ◽

10.1002/chin.200323215 ◽

2003 ◽

Vol 34 (23) ◽

Author(s):

Klaus Griessbach ◽

Monika Klimt ◽

Alwine Schulze Elfringhoff ◽

Matthias Lehr

Keyword(s):

Arachidonic Acid ◽

Phospholipase A2 ◽

Carboxylic Acids ◽

Cytosolic Phospholipase A2 ◽

Activity Relationship ◽

Arachidonic Acid Release ◽

Cytosolic Phospholipase ◽

Structure Activity ◽

Acid Release

Structure–activity relationship studies on 1-(2-oxopropyl)indole-5-carboxylic acids acting as inhibitors of cytosolic phospholipase A2α: Effect of substituents at the indole 3-position on activity, solubility, and metabolic stability

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2016.10.039 ◽

2017 ◽

Vol 125 ◽

pp. 1107-1114 ◽

Cited By ~ 2

Author(s):

Martina Arnsmann ◽

Walburga Hanekamp ◽

Alwine Schulze Elfringhoff ◽

Matthias Lehr

Keyword(s):

Carboxylic Acids ◽

Metabolic Stability ◽

Activity Relationship ◽

Effect Of Substituents ◽

Cytosolic Phospholipase ◽

Structure Activity ◽

Study of indole derivative inhibitors of Cytosolic phospholipase A2α based on Quantitative Structure Activity Relationship

Chemometrics and Intelligent Laboratory Systems ◽

10.1016/j.chemolab.2011.11.011 ◽

2012 ◽

Vol 114 ◽

pp. 1-9 ◽

Cited By ~ 2

Author(s):

Xiaoquan Lu ◽

Dongqin Ji ◽

Jing Chen ◽

Xibin Zhou ◽

Haicai Shi

Keyword(s):

Indole Derivative ◽

Quantitative Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Cytosolic Phospholipase ◽

Structure Activity ◽

Hologram quantative structure–activity relationship studies on 1-(5-carboxyindol-1-yl)propan-2-one inhibitors of human cytosolic phospholipase A2α

Medicinal Chemistry Research ◽

10.1007/s00044-013-0763-5 ◽

2013 ◽

Vol 23 (3) ◽

pp. 1512-1518 ◽

Cited By ~ 7

Author(s):

Xiang-Lin Yang ◽

Yuan Zhou ◽

Xin-Ling Liu

Keyword(s):

Activity Relationship ◽

Cytosolic Phospholipase ◽

Structure Activity ◽

Structure–activity relationship studies on 1-(5-carboxyindol-1-yl)-propan-2-one inhibitors of human cytosolic phospholipase A2α: Variation of the activated ketone moiety

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2011.01.085 ◽

2011 ◽

Vol 21 (6) ◽

pp. 1773-1776 ◽

Cited By ~ 6

Author(s):

Martina Kaptur ◽

Alwine Schulze Elfringhoff ◽

Matthias Lehr

Keyword(s):

Activity Relationship ◽

Cytosolic Phospholipase ◽

Structure Activity ◽

Structure-Activity Relationship Studies of 1-Substituted 3-Dodecanoylindole-2-carboxylic Acids as Inhibitors of Cytosolic Phospholipase A2-Mediated Arachidonic Acid Release in Intact Platelets

Archiv der Pharmazie ◽

10.1002/ardp.200290008 ◽

2002 ◽

Vol 335 (1112) ◽

pp. 547-555 ◽

Cited By ~ 6

Author(s):

Klaus Griessbach ◽

Monika Klimt ◽

Alwine Schulze Elfringhoff ◽

Matthias Lehr

Keyword(s):

Arachidonic Acid ◽

Phospholipase A2 ◽

Carboxylic Acids ◽

Cytosolic Phospholipase A2 ◽

Activity Relationship ◽

Arachidonic Acid Release ◽

Cytosolic Phospholipase ◽

Structure Activity ◽

Acid Release

Discovery and Structure–Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1)

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.6b00373 ◽

2016 ◽

Vol 59 (13) ◽

pp. 6248-6264 ◽

Cited By ~ 16

Author(s):

John L. Gilmore ◽

James E. Sheppeck ◽

Scott H. Watterson ◽

Lauren Haque ◽

Parag Mukhopadhyay ◽

...

Keyword(s):

Activity Relationship ◽

Structure Activity ◽

Sphingosine 1 Phosphate ◽

Direct Acting

Characterization of the Human and Mouse Sphingosine 1-Phosphate Receptor, S1P5(Edg-8): Structure−Activity Relationship of Sphingosine1-Phosphate Receptors†

Biochemistry ◽

10.1021/bi011606i ◽

2001 ◽

Vol 40 (46) ◽

pp. 14053-14060 ◽

Cited By ~ 58

Author(s):

Dong-Soon Im ◽

Jeremy Clemens ◽

Timothy L. Macdonald ◽

Kevin R. Lynch

Keyword(s):

Activity Relationship ◽

Structure Activity ◽

Sphingosine 1 Phosphate ◽

Relationship Of ◽

Human And Mouse

Structure–activity relationship studies on 1-heteroaryl-3-phenoxypropan-2-ones acting as inhibitors of cytosolic phospholipase A2α and fatty acid amide hydrolase: replacement of the activated ketone group by other serine traps

Journal of Enzyme Inhibition and Medicinal Chemistry ◽

10.3109/14756366.2015.1057721 ◽

2015 ◽

Vol 31 (4) ◽

pp. 653-663 ◽

Cited By ~ 3

Author(s):

Tom Sundermann ◽

Walburga Hanekamp ◽

Matthias Lehr

Keyword(s):

Fatty Acid ◽

Fatty Acid Amide Hydrolase ◽

Acid Amide ◽

Activity Relationship ◽

Ketone Group ◽

Cytosolic Phospholipase ◽

Structure Activity ◽

Cytosolic Phospholipase A2α ◽

Amide Hydrolase ◽

Fatty Acid Amide