Structure–activity relationship studies of 3-dodecanoylindole-2-carboxylic acid inhibitors of cytosolic phospholipase A2α-mediated arachidonic acid release in intact platelets: variation of the keto moiety

Activity Relationship ◽

Cytosolic Phospholipase ◽

Structure Activity ◽

Acid Release ◽

Structure—Activity Relationship Studies of 1-Substituted 3-Dodecanoylindole-2-carboxylic Acids as Inhibitors of Cytosolic Phospholipase A2-Mediated Arachidonic Acid Release in Intact Platelets.

ChemInform ◽

10.1002/chin.200323215 ◽

2003 ◽

Vol 34 (23) ◽

Author(s):

Klaus Griessbach ◽

Monika Klimt ◽

Alwine Schulze Elfringhoff ◽

Matthias Lehr

Keyword(s):

Arachidonic Acid ◽

Phospholipase A2 ◽

Carboxylic Acids ◽

Cytosolic Phospholipase A2 ◽

Activity Relationship ◽

Cytosolic Phospholipase ◽

Structure Activity ◽

Acid Release

Structure-Activity Relationship Studies of 1-Substituted 3-Dodecanoylindole-2-carboxylic Acids as Inhibitors of Cytosolic Phospholipase A2-Mediated Arachidonic Acid Release in Intact Platelets

Archiv der Pharmazie ◽

10.1002/ardp.200290008 ◽

2002 ◽

Vol 335 (1112) ◽

pp. 547-555 ◽

Cited By ~ 6

Author(s):

Klaus Griessbach ◽

Monika Klimt ◽

Alwine Schulze Elfringhoff ◽

Matthias Lehr

Keyword(s):

Arachidonic Acid ◽

Phospholipase A2 ◽

Carboxylic Acids ◽

Cytosolic Phospholipase A2 ◽

Activity Relationship ◽

Cytosolic Phospholipase ◽

Structure Activity ◽

Acid Release

Effects of Synthetic Sphingosine-1-Phosphate Analogs on Cytosolic Phospholipase A2α–Independent Release of Arachidonic Acid and Cell Toxicity in L929 Fibrosarcoma Cells: the Structure–Activity Relationship

Journal of Pharmacological Sciences ◽

10.1254/jphs.08284fp ◽

2009 ◽

Vol 109 (3) ◽

pp. 431-443 ◽

Cited By ~ 6

Author(s):

Masaya Shimizu ◽

Yuki Muramatsu ◽

Eiko Tada ◽

Takeshi Kurosawa ◽

Erika Yamaura ◽

...

Keyword(s):

Arachidonic Acid ◽

Activity Relationship ◽

Cell Toxicity ◽

Cytosolic Phospholipase ◽

Structure Activity ◽

Fibrosarcoma Cells ◽

Sphingosine 1 Phosphate ◽

A pyrrolidine-based specific inhibitor of cytosolic phospholipase A2α blocks arachidonic acid release in a variety of mammalian cells

Biochimica et Biophysica Acta (BBA) - Biomembranes ◽

10.1016/s0005-2736(01)00349-2 ◽

2001 ◽

Vol 1513 (2) ◽

pp. 160-166 ◽

Cited By ~ 70

Author(s):

Farideh Ghomashchi ◽

Allison Stewart ◽

Ying Hefner ◽

Sasanka Ramanadham ◽

John Turk ◽

...

Keyword(s):

Arachidonic Acid ◽

Mammalian Cells ◽

Specific Inhibitor ◽

Cytosolic Phospholipase ◽

Acid Release ◽

Inhibition of arachidonic acid release and cytosolic phospholipase A2α activity by d-erythro-sphingosine

European Journal of Pharmacology ◽

10.1016/j.ejphar.2003.10.053 ◽

2004 ◽

Vol 484 (1) ◽

pp. 9-17 ◽

Cited By ~ 22

Author(s):

Hiroyuki Nakamura ◽

Testuya Hirabayashi ◽

Akiyoshi Someya ◽

Masaya Shimizu ◽

Toshihiko Murayama

Keyword(s):

Arachidonic Acid ◽

Cytosolic Phospholipase ◽

Acid Release ◽

Expression of Cytosolic Phospholipase A2α in Murine C12 Cells, a Variant of L929 Cells, Induces Arachidonic Acid Release in Response to Phorbol Myristate Acetate and Ca2+ Ionophores, but Not to Tumor Necrosis Factor-α

Journal of Pharmacological Sciences ◽

10.1254/jphs.fpj04033x ◽

2004 ◽

Vol 96 (3) ◽

pp. 324-332 ◽

Cited By ~ 25

Author(s):

Masaya Shimizu ◽

Chihiro Azuma ◽

Tomoko Taniguchi ◽

Toshihiko Murayama

Keyword(s):

Arachidonic Acid ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Myristate Acetate ◽

Cytosolic Phospholipase ◽

Acid Release ◽

Cytosolic Phospholipase A2α ◽

Factor Α ◽

Necrosis Factor

Structure–activity relationship studies on 1-(2-oxopropyl)indole-5-carboxylic acids acting as inhibitors of cytosolic phospholipase A2α: Effect of substituents at the indole 3-position on activity, solubility, and metabolic stability

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2016.10.039 ◽

2017 ◽

Vol 125 ◽

pp. 1107-1114 ◽

Cited By ~ 2

Author(s):

Martina Arnsmann ◽

Walburga Hanekamp ◽

Alwine Schulze Elfringhoff ◽

Matthias Lehr

Keyword(s):

Carboxylic Acids ◽

Metabolic Stability ◽

Activity Relationship ◽

Effect Of Substituents ◽

Cytosolic Phospholipase ◽

Structure Activity ◽

Cross-talk between Cytosolic Phospholipase A2α (cPLA2α) and Secretory Phospholipase A2(sPLA2) in Hydrogen Peroxide-induced Arachidonic Acid Release in Murine Mesangial Cells

Journal of Biological Chemistry ◽

10.1074/jbc.m300424200 ◽

2003 ◽

Vol 278 (26) ◽

pp. 24153-24163 ◽

Cited By ~ 110

Author(s):

Won K. Han ◽

Adam Sapirstein ◽

Cheng C. Hung ◽

Alessandro Alessandrini ◽

Joseph V. Bonventre

Keyword(s):

Hydrogen Peroxide ◽

Arachidonic Acid ◽

Phospholipase A2 ◽

Cross Talk ◽

Mesangial Cells ◽

Secretory Phospholipase A2 ◽

Cytosolic Phospholipase ◽

Acid Release ◽

Hydrogen peroxide-induced arachidonic acid release in L929 cells; roles of Src, protein kinase C and cytosolic phospholipase A2α

European Journal of Pharmacology ◽

10.1016/j.ejphar.2006.06.071 ◽

2006 ◽

Vol 546 (1-3) ◽

pp. 1-10 ◽

Cited By ~ 8

Author(s):

Tomoko Taniguchi ◽

Masaya Shimizu ◽

Hiroyuki Nakamura ◽

Tetsuya Hirabayashi ◽

Hiromichi Fujino ◽

...

Keyword(s):

Hydrogen Peroxide ◽

Arachidonic Acid ◽

Protein Kinase C ◽

Protein Kinase ◽

L929 Cells ◽

Cytosolic Phospholipase ◽

Kinase C ◽

Acid Release ◽

Corrigendum to “A pyrrolidine-based specific inhibitor of cytosolic phospholipase A2α blocks arachidonic acid release in a variety of mammalian cells.” [Biochem. Biophys. Acta 1513 (2001) 160–166]

Biochimica et Biophysica Acta (BBA) - Biomembranes ◽

10.1016/j.bbamem.2010.11.018 ◽

2011 ◽

Vol 1808 (6) ◽

pp. 1779 ◽

Cited By ~ 1

Author(s):

Farideh Ghomashchi ◽

Allison Stewart ◽

Ying Hefner ◽

Sasanka Ramanadham ◽

John Turk ◽

...

Keyword(s):

Arachidonic Acid ◽

Mammalian Cells ◽

Specific Inhibitor ◽

Cytosolic Phospholipase ◽

Acid Release ◽