Correlation of Receptor Occupancy of Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Mouse Brain With In Vivo Activity of Allosteric mGluR1 Antagonists

Receptor Occupancy ◽

Receptor Subtype ◽

Relationship between In Vivo Receptor Occupancy and Efficacy of Metabotropic Glutamate Receptor Subtype 5 Allosteric Modulators with Different In Vitro Binding Profiles

Neuropsychopharmacology ◽

10.1038/npp.2014.245 ◽

2014 ◽

Vol 40 (3) ◽

pp. 755-765 ◽

Cited By ~ 22

Author(s):

Jerri M Rook ◽

Mohammed N Tantawy ◽

Mohammad S Ansari ◽

Andrew S Felts ◽

Shaun R Stauffer ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Occupancy ◽

Receptor Subtype ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

In Vitro Binding ◽

Vitro Binding

In vivo positron emission tomography imaging with [11C]ABP688: binding variability and specificity for the metabotropic glutamate receptor subtype 5 in baboons

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-010-1723-7 ◽

2011 ◽

Vol 38 (6) ◽

pp. 1083-1094 ◽

Cited By ~ 39

Author(s):

Christine DeLorenzo ◽

Matthew S. Milak ◽

Kathleen G. Brennan ◽

J. S. Dileep Kumar ◽

J. John Mann ◽

...

Keyword(s):

Positron Emission Tomography ◽

Glutamate Receptor ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Receptor Subtype ◽

Tomography Imaging ◽

Metabotropic Glutamate ◽

Positron Emission

Synthesis, radiolabeling, in vitro and in vivo evaluation of [18F]-FPECMO as a positron emission tomography radioligand for imaging the metabotropic glutamate receptor subtype 5

Nuclear Medicine and Biology ◽

10.1016/j.nucmedbio.2009.03.005 ◽

2009 ◽

Vol 36 (6) ◽

pp. 613-622 ◽

Cited By ~ 14

Author(s):

Christophe Lucatelli ◽

Michael Honer ◽

Jean-Frédéric Salazar ◽

Tobias L. Ross ◽

P. August Schubiger ◽

...

Keyword(s):

Positron Emission Tomography ◽

Glutamate Receptor ◽

Emission Tomography ◽

Receptor Subtype ◽

In Vivo Evaluation ◽

Metabotropic Glutamate ◽

Positron Emission

[3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine Binding to Metabotropic Glutamate Receptor Subtype 5 in Rodent Brain: In Vitro and in Vivo Characterization

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.102.040618 ◽

2002 ◽

Vol 303 (3) ◽

pp. 1044-1051 ◽

Cited By ~ 83

Author(s):

Jeffery J. Anderson ◽

Sara P. Rao ◽

Blake Rowe ◽

Darlene R. Giracello ◽

Greg Holtz ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Subtype ◽

Metabotropic Glutamate ◽

Rodent Brain ◽

In Vivo Characterization

In Vivo Ketamine-Induced Changes in [ 11 C]ABP688 Binding to Metabotropic Glutamate Receptor Subtype 5

Biological Psychiatry ◽

10.1016/j.biopsych.2014.06.024 ◽

2015 ◽

Vol 77 (3) ◽

pp. 266-275 ◽

Cited By ~ 46

Author(s):

Christine DeLorenzo ◽

Nicole DellaGioia ◽

Michael Bloch ◽

Gerard Sanacora ◽

Nabeel Nabulsi ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Subtype ◽

Metabotropic Glutamate ◽

Induced Changes

Discovery of Molecular Switches That Modulate Modes of Metabotropic Glutamate Receptor Subtype 5 (mGlu5) Pharmacology in Vitro and in Vivo within a Series of Functionalized, Regioisomeric 2- and 5-(Phenylethynyl)pyrimidines

Journal of Medicinal Chemistry ◽

10.1021/jm900654c ◽

2009 ◽

Vol 52 (14) ◽

pp. 4103-4106 ◽

Cited By ~ 63

Author(s):

Sameer Sharma ◽

Jeffrey Kedrowski ◽

Jerri M. Rook ◽

Randy L. Smith ◽

Carrie K. Jones ◽

...

Keyword(s):

Glutamate Receptor ◽

Molecular Switches ◽

Receptor Subtype ◽

In vitro and in vivo evaluation of [18F]-FDEGPECO as a PET tracer for imaging the metabotropic glutamate receptor subtype 5 (mGluR5)

NeuroImage ◽

10.1016/j.neuroimage.2011.03.024 ◽

2011 ◽

Vol 56 (3) ◽

pp. 984-991 ◽

Cited By ~ 11

Author(s):

Cindy A. Wanger-Baumann ◽

Linjing Mu ◽

Michael Honer ◽

Sara Belli ◽

Malte F. Alf ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Subtype ◽

In Vivo Evaluation ◽

Metabotropic Glutamate ◽

Pet Tracer

Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity

Molecular Pharmacology ◽

10.1124/mol.110.067207 ◽

2010 ◽

Vol 78 (6) ◽

pp. 1105-1123 ◽

Cited By ~ 139

Author(s):

Alice L. Rodriguez ◽

Mark D. Grier ◽

Carrie K. Jones ◽

Elizabeth J. Herman ◽

Alexander S. Kane ◽

...

Keyword(s):

Functional Diversity ◽

Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulators ◽

Behavioral Models ◽

Metabotropic Glutamate ◽

Antipsychotic Activity

Pharmacogenomics of metabotropic glutamate receptor subtype 1 and in vivo malignant melanoma formation

The Journal of Dermatology ◽

10.1111/j.1346-8138.2010.00833.x ◽

2010 ◽

Vol 37 (7) ◽

pp. 635-646 ◽

Cited By ~ 15

Author(s):

Mohamed ABDEL-DAIM ◽

Yoko FUNASAKA ◽

Mari KOMOTO ◽

Yoko NAKAGAWA ◽

Emmy YANAGITA ◽

...

Keyword(s):

Malignant Melanoma ◽

Glutamate Receptor ◽

Receptor Subtype ◽

A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.104.079244 ◽

2004 ◽

Vol 313 (1) ◽

pp. 199-206 ◽

Cited By ~ 218

Author(s):

Gene G. Kinney ◽

Julie A. O'Brien ◽

Wei Lemaire ◽

Maryann Burno ◽

Denise J. Bickel ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Behavioral Models ◽

Positive Allosteric Modulator ◽