scholarly journals Factors affecting facial development and formation of cleft lip and palate: a literature review

2020 ◽  
Vol 29 (2) ◽  
pp. 22-35
Author(s):  
Mārtiņš Vaivads ◽  
Evija Balode ◽  
Māra Pilmane
Keyword(s):  
Growth Factors ◽  
Literature Review ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Developmental Process ◽  
Factors Affecting ◽  
Facial Region ◽  
Facial Anomalies ◽  
Multiple Genes ◽  
Facial Development

The craniofacial region forms in a complicated developmental process regulated by multiple genes and growth factors. Disruption and dysregulation during facial development can lead to multiple congenital facial anomalies including cleft lip and palate. This literature review collects and analyses the existing information about the interaction of multiple growth factors and genes within the developing facial region and their association with facial pathology. The factors analysed in this review are DLX4, FOXE1, HOXB3, MSX2, PAX7, PAX9, RYK, SHH, SOX3, WNT3A, WNT9B and BARX1.

scholarly journals Maxillary expansion in grafted alveolar arches in patients with cleft lip and palate: A literature review

2021 ◽  
pp. 100034
Author(s):  
Adriana Parra Barillas ◽  
Dimitrios Michelogiannakis ◽  
P. Emile Rossouw ◽  
Fawad Javed
Keyword(s):  
Literature Review ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Maxillary Expansion

Genetics of cleft lip and palate revisited

2003 ◽  
Vol 27 (4) ◽  
pp. 311-320 ◽  
Author(s):  
Puneet Batra ◽  
Ritu Duggal ◽  
Hari Parkash
Keyword(s):  
Cleft Palate ◽  
Cleft Lip ◽  
Speech Therapy ◽  
Cleft Lip And Palate ◽  
Gene List ◽  
Complex Trait ◽  
Case Control Studies ◽  
Systematic Screening ◽  
Complex Interactions ◽  
Facial Development

Cleft lip with or without cleft palate (CL/CP) is one of the most common structural birth defects, with treatment including multiple surgeries, speech therapy, and dental and orthodontic treatments over the first 18 years of life. Providing care for these patients and families includes educating patients and parents about the genetics of CL/CP, as well as meeting the immediate medical needs.Attempts at identifying susceptibility loci via family and case-control studies have proved inconsistent. It is likely that initial predictions of the complex interactions involved in facial development were underestimated. The candidate gene list for CL/P is getting longer and the need for an impartial, systematic screening technique, to implicate or refute the inclusion of particular loci, is apparent. So we are faced with the question "Can this complex trait be too complex?"The aim of this review is to make the dentist aware of the differences between syndromic and non-syndromic cleft as well as understanding the etiological variation in cleft lip with and without cleft palate. This will aid the dentist in diagnosis and give proper genetic counseling to parents and patients of cleft lip and palate.

Fetal dental panorama on three-dimensional ultrasound imaging of cleft lip and palate and other facial anomalies

2018 ◽  
Vol 23 (4) ◽  
pp. 1561-1568
Author(s):  
Romain Nicot ◽  
Daniel Rotten ◽  
Yasmin Opdenakker ◽  
Bothild Kverneland ◽  
Joël Ferri ◽  
...  
Keyword(s):  
Ultrasound Imaging ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Three Dimensional ◽  
Facial Anomalies

Assessing Intelligibility in Speakers with Cleft Palate: A Critical Review of the Literature

2002 ◽  
Vol 39 (1) ◽  
pp. 50-58 ◽  
Author(s):  
Tara L. Whitehill
Keyword(s):  
Literature Review ◽  
Speech Intelligibility ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Relevant Literature ◽  
Reliability And Validity ◽  
Review Of The Literature ◽  
Similar Measure ◽  
Adequate Definition ◽  
Research Questions

Objective A literature review was conducted in order to investigate three research questions: how is speech intelligibility being measured in speakers with cleft lip and palate? Is intelligibility adequately being distinguished from related measures such as acceptability? Has there been an increased understanding of intelligibility deficits in speakers with cleft lip and palate? Fifty-seven relevant articles published between 1960 and 1998 were included in the analysis. Results The results showed an increase in the number of articles that included a measure of intelligibility or a similar measure. Several concerns were raised as a result of the review, including the reliability and validity of measures being employed, adequate definition and differentiation of terms, and the need to determine speech and nonspeech variables contributing to reductions in intelligibility. Relevant literature on intelligibility from fields outside cleft lip and palate is reviewed, and a number of recommendations are made regarding the measurement of intelligibility in speakers with cleft lip and palate.

Multivariate analysis of factors affecting dental arch relationships in Japanese unilateral cleft lip and palate patients at Hokkaido University Hospital

2008 ◽  
Vol 67 (2) ◽  
pp. 45-53 ◽  
Author(s):  
Mohammad Khursheed Alam ◽  
Takashi S. Kajii ◽  
Mino Koshikawa-Matsuno ◽  
Yuki Sugawara-Kato ◽  
Yoshiaki Sato ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
University Hospital ◽  
Dental Arch ◽  
Factors Affecting
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