scholarly journals Hybrid Vigor and Variation of Mammary Growth Response and Body Growth in F1 Hybrid between Inbred Strains of Mice

1960 ◽  
Vol 10 (4) ◽  
pp. 233-246
Author(s):  
Junzo YAMADA
Keyword(s):  
Growth Response ◽  
Inbred Strains ◽  
Body Growth ◽  
Hybrid Vigor ◽  
F1 Hybrid ◽  
Inbred Strains Of Mice

scholarly journals Histoincompatibility and maternal immunological status as determinants of fetoplacental weight and litter size in rodents.

1975 ◽  
Vol 142 (1) ◽  
pp. 180-196 ◽  
Author(s):  
A E Beer ◽  
J R Scott ◽  
R E Billingham
Keyword(s):  
Significant Contribution ◽  
Passive Immunization ◽  
Inbred Strains ◽  
Hybrid Vigor ◽  
F1 Hybrid ◽  
Inbred Strains Of Mice ◽  
Tissue Antigens ◽  
Similar Weight ◽  
Rat Strain ◽  
Additional Support

Studies conducted upon inbred strains of mice, hamsters and rats have shown that following the interstrain matings the now familiar covert reactivity of pregnant females to the alloantigens of their conceptuses may benefit the latter in two ways; firstly, it exerts a significant influence upon placental weight, and indirectly upon the birth weight of the fetus-allogeneic placentas tending to be heavier than syngeneic placentas, and mothers specifically presensitized against alien paternal tissue antigens gestate fetuses with heavier placentas than normal females. Specifically tolerant mothers, on the other hand, produce smaller, F1 hybrid, fetoplacental (fp) units. The classic notion that the disparity between the birth weights of F1 hybrid and homozygous offspring is due to hybrid vigor has been challenged by the finding that DA and (DA times F1)F1 hybrid blastocysts transferred to the uteri of genetically tolerant (DA times F1)F1 hybrid rats produce fp units of similar weight Maternal immunological reactivity against the fetus qua allograft may make a significant contribution here. Additional support for the premise that maternal reactivity against fetal alloantigens in some way promotes the growth of the fp unit was afforded by the finding that excision of the para-aortic lymph nodes (which drain the uterine horns) from females before interstrain matings resulted in smaller fp units than in females subjected to sham operations. The finding with one rat strain combination that passive immunization of females with serum against their F1 hybrid conceptuses promoted the growth of the latter suggests that a humoral rather than a cellular immunity may be involved. Secondly, in the three species studied, it was observed that genetic disparity between a conceptus and its mother significantly improved its chances of implantation and development to term.

TRANSPLANTATION OF THYMIC TISSUE IN INBRED STRAINS OF MICE

1961 ◽  
Vol 22 (4) ◽  
pp. 349-359 ◽  
Author(s):  
FLORENCE J. PEPPER
Keyword(s):  
Lymph Nodes ◽  
Adrenal Glands ◽  
Inbred Strains ◽  
Body Growth ◽  
Thymus Gland ◽  
Thymic Tissue ◽  
Adrenocortical Hormones ◽  
Loss Of Weight ◽  
Inbred Strains Of Mice ◽  
Different Ages

SUMMARY Thymic tissue has been transplanted between donor and host mice of different ages. It has been found that thymic tissue more than a few days old loses weight rapidly when transplanted to a host, and that beyond this age loss of weight is independent of the age of either donor or host. For the first few days after birth the thymus gland is capable of growth when transplanted to a host and, unlike the host's own thymus, it is unaffected by the increased output of adrenocortical hormones which occurs during pregnancy. The behaviour of a thymic graft seems to be independent of the presence or absence of the host's own thymus gland. The presence of additional thymic tissue in a host appears to have no effect on body growth, weight of adrenal glands, gonads and superficial lymph nodes, or on the weight and histological condition of the thymus of the host.

scholarly journals STRAIN DIFFERENCES IN LOCAL HEMORRHAGIC RESPONSE (SHWARTZMAN-LIKE REACTION) OF MICE TO A SINGLE INTRADERMAL INJECTION OF BACTERIAL POLYSACCHARIDES

1957 ◽  
Vol 105 (6) ◽  
pp. 653-664 ◽  
Author(s):  
Margaret G. Kelly ◽  
Norman H. Smith ◽  
Isidore Wodinsky ◽  
David P. Rall
Keyword(s):  
Strain Differences ◽  
Inbred Strains ◽  
Blocking Agent ◽  
Intradermal Injection ◽  
F1 Hybrid ◽  
Hemorrhagic Necrosis ◽  
Inbred Strains Of Mice ◽  
Anticoagulant Drug ◽  
Shwartzman Reaction ◽  
Hemorrhagic Lesion

A survey of inbred strains of mice was made to determine whether the phenomenon of dermal hemorrhagic necrosis, as described in rabbits by Shwartzman, could be elicited in mice by bacterial polysaccharide preparations of demonstrated activity in rabbits. The polysaccharide preparations used were obtained from cultures of S. marcescens, S. typhosa, Ps. aeruginosa, and H. pertussis. Ten of the strains tested were unreactive. Three strains of mice and one F1 hybrid subline developed a hemorrhagic lesion at the site of injection of a single, relatively high intradermal dose of polysaccharide. Some increase in incidence of hemorrhagic lesions was obtained when the intradermal dose was followed in 24 hours by an intravenous injection. In the gross and microscopically, the skin lesion produced in mice resembled the Shwartzman reaction in rabbits. An adrenergic blocking agent, SY-28, and an anticoagulant drug, coumadin, both of which block the dermal Shwartzman reaction in rabbits, also blocked the hemorrhagic skin reaction in mice.

Thyroidal Iodine Metabolism in Inbred and F1 Hybrid Mice

1957 ◽  
Vol 188 (3) ◽  
pp. 499-502 ◽  
Author(s):  
C. K. Chai ◽  
A. Amin ◽  
E. P. Reineke
Keyword(s):  
Inverse Relationship ◽  
Genetic Factors ◽  
Strain Differences ◽  
Inbred Strains ◽  
The Other ◽  
Output Rate ◽  
F1 Hybrid ◽  
Inbred Strains Of Mice ◽  
Iodine Metabolism ◽  
Hybrid Mice

Thyroidal iodine metabolism was studied in four inbred strains of mice and two groups of F1 hybrids by use of radioiodine. Significant strain differences were found in both the 48-hour thyroidal retention of I131 and its output rate constant. Three closely related groups studied were C57BL/6, C57BR/cd and BBF1, their F1 hybrid. The other three groups included A/Jax, BALB/c and CAF1, their F1 hybrid. C57BL/6 mice had a significantly faster output rate and lower 48-hour I131 retention than any other group. The first three groups listed had a more rapid output rate and lower 48-hour retention than the last three. In intergroup comparisons and inverse relationship between I131 output rate and 48-hour retention was clearly shown. The results indicate that in mice pituitary TSH output, as indicated by thyroidal I131 output rate and thyroidal iodine pool size, is controlled by separate genetic factors.

scholarly journals FURTHER STUDIES OF THE STIMULATION OF DNA SYNTHESIS IN CULTURES OF SPLEEN CELL SUSPENSIONS BY HOMOLOGOUS CELLS IN INBRED STRAINS OF MICE AND RATS

1965 ◽  
Vol 122 (4) ◽  
pp. 759-770 ◽  
Author(s):  
Richard W. Dutton
Keyword(s):  
Spleen Cell ◽  
Large Fraction ◽  
Inbred Strains ◽  
Cell Suspensions ◽  
F1 Hybrids ◽  
Hybrid Cells ◽  
F1 Hybrid ◽  
Inbred Strains Of Mice ◽  
Different Strains

The early proliferative response previously demonstrated in rabbits has now been shown to follow the mixing of spleen cell suspensions from 2 inbred strains of mice or rats. The size of the response is comparable to that seen in cells from hyperimmune animals exposed to antigen in vitro. Autoradiographs of cells from stimulated cultures showed 1 to 4 per cent of the total population had incorporated thymidine. Modifications in the conditions necessary for the culture of mice and rat spleen cell suspensions and the measurement of thymidine incorporation are described. No responses were observed in isologous mixes. The responses obtained on mixing individual pairs of spleens from different strains showed relatively little variation. Responses were obtained in all of the 21 possible combinations between 7 inbred strains of mice. Responses were obtained when parental cells were mixed with their F1 hybrids. Analysis of these responses showed that, in every case, parental-F1 hybrid responses were less intense than those between the 2 parents. It was shown that there was no inherent defect in the ability of the hybrid cells to respond when mixed with an unrelated strain. The results suggested that the hybrid cells made no response to the parent cells although this was not conclusively established. This has been taken as circumstantial evidence that the response is immunological in nature. The significance of the vigor of the response and the large fraction of the immunologically competent cells that take part is discussed.

Effects of Foster Nursing on Alcohol Selection in Inbred Strains of Mice

1972 ◽  
Vol 33 (2) ◽  
pp. 494-503 ◽  
Author(s):  
Setsuo Komura ◽  
Masao Ueda ◽  
Toshikiyo Kobayashi
Keyword(s):  
Inbred Strains ◽  
Inbred Strains Of Mice
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