scholarly journals Cell Age Distribution of Erythrocytes at the Incidence of Cerebral Stroke in Stroke-Prone Spontaneously Hypertensive Rats, and Their Glutathione Peroxidase Activity.

1998 ◽  
Vol 62 (3) ◽  
pp. 484-490 ◽  
Author(s):  
Tetsuo MURAKAMI ◽  
Kumiko TAKEMORI ◽  
Norifumi SHIRASAkA ◽  
Hajime YOSHIZUMI ◽  
Hiroyuki ITO
Keyword(s):  
Glutathione Peroxidase ◽  
Peroxidase Activity ◽  
Spontaneously Hypertensive Rats ◽  
Age Distribution ◽  
Cerebral Stroke ◽  
Hypertensive Rats ◽  
Glutathione Peroxidase Activity ◽  
Spontaneously Hypertensive ◽  
Cell Age

scholarly journals Changes in Cell Age Distribution of Erythrocytes and in Glutathione Peroxidase Activity along with Aging of SHRSP

1996 ◽  
Vol 37 (4) ◽  
pp. 556-556
Author(s):  
Tetsuo Murakami ◽  
Kumiko Takemori ◽  
Hajime Yoshizumi ◽  
Hiroyuki Ito
Keyword(s):  
Glutathione Peroxidase ◽  
Peroxidase Activity ◽  
Age Distribution ◽  
Glutathione Peroxidase Activity ◽  
Cell Age

scholarly journals Prevention of cerebral stroke, cardiac and vascular hypertrophy in stroke-prone spontaneously hypertensive rats by arotmolol (Report II)

1988 ◽  
Vol 46 ◽  
pp. 264
Author(s):  
Akira Miyagishi ◽  
Takashi Maniwa ◽  
Tsuyoshi Noguchi ◽  
Takashi Miyano ◽  
Youichi Hara
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Cerebral Stroke ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Vascular Hypertrophy

GLUTATHIONE PEROXIDASE, GLUTATHIONE REDUCTASE, SUPEROXIDE DISMUTASE, AND CATALASE ACTIVITY IN THE KIDNEY OF SPONTANEOUSLY HYPERTENSIVE RATS: EFFECT OF WILD THYME

2011 ◽  
Vol 29 ◽  
pp. e317-e318
Author(s):  
N. Mihailovic-Stanojevic ◽  
B. Bugarski ◽  
D. Komes ◽  
Z. Miloradovic ◽  
J. Grujic Milanovic ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Glutathione Reductase ◽  
Catalase Activity ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Wild Thyme

scholarly journals Hemodynamics and Metabolism in Stroke-Prone Spontaneously Hypertensive Rats before Manifestation of Brain Infarcts

1999 ◽  
Vol 19 (11) ◽  
pp. 1238-1246 ◽  
Author(s):  
Günter Mies ◽  
Dirk Hermann ◽  
Ursula Ganten ◽  
Konstantin-Alexander Hossmann
Keyword(s):  
Protein Synthesis ◽  
Spontaneously Hypertensive Rats ◽  
Brain Infarction ◽  
Chromosome 1 ◽  
Cerebral Stroke ◽  
Hypertensive Rats ◽  
Tissue Ph ◽  
Spontaneously Hypertensive ◽  
Brain Infarcts ◽  
Functional Symptoms

Genomic screening of hybrids from stroke-prone (SHR-SP) and stroke-resistant spontaneously hypertensive rats (SHR) identified a STR1 locus on the rat chromosome 1, which correlates with the susceptibility to cerebral stroke but not with hypertension. The authors examined whether this genetic abnormality is associated with hemodynamic or metabolic alterations in the brain that can be detected before the manifestation of brain infarction. Starting at 6 weeks of age, SHR-SP were fed with a salt-rich diet to accelerate arterial hypertension. At the age of 12 weeks, animals developed functional symptoms and were age-matched with symptom-negative SHR-SP to differentiate between presymptomatic and postsymptomatic changes. Brains were investigated by multiparametric imaging comprising quantitative double-tracer autoradiography of CBF and cerebral protein synthesis (CPS); bioluminescence imaging of regional ATP, glucose, and lactate content; and umbelliferone fluoroscopic imaging of tissue pH. None of the animals exhibited focal hemodynamic or biochemical abnormalities. In symptom-negative SHR-SP, global CBF was 1.1 ± 0.3 mL. g–1 · min–1, cortical CPS was 10.1 ± 3.1 nmol · g–1 · min–1, and cortical ATP, glucose, lactate, and pH levels were in the normal range. In SHR-SP with functional symptoms, ATP, glucose, and lactate levels also were normal, but tissue pH exhibited periventricular alkalosis, CBF was significantly reduced to 0.7 ± 0.2 mL · g–1 · min–1 ( P < 0.001), and cortical CPS was significantly reduced to 6.7 ± 2.1 nmol · g–1 · min–1 ( P < 0.001). The decline in brain perfusion of SHR-SP correlated significantly with both the severity of functional deficits and the decline of protein synthesis. Our observations demonstrate that SHR-SP had already developed functional symptoms before the manifestation of overt brain infarcts and that the symptoms are initiated by a decline in global CBF and cortical CPS. Genetic abnormalities in SHR-SP are associated with a diffuse vascular process that results in global decompensation of blood flow well before the onset of focal brain infarction.

Prediction of Stroke Lesions in Stroke-prone Spontaneously Hypertensive Rats by Glutathione Peroxidase in Erythrocytes

1995 ◽  
Vol 59 (8) ◽  
pp. 1459-1463 ◽  
Author(s):  
Tetsuo Murakami ◽  
Kumiko Takemori ◽  
Hajime Yoshizumi
Keyword(s):  
Glutathione Peroxidase ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals Effect of Chlorella and Its Fractions on Blood Pressure, Cerebral Stroke Lesions, and Life-Span in Stroke-Prone Spontaneously Hypertensive Rats

2006 ◽  
Vol 52 (6) ◽  
pp. 457-466 ◽  
Author(s):  
Hiroshi SANSAWA ◽  
Masatoshi TAKAHASHI ◽  
Satoru TSUCHIKURA ◽  
Hiroshi ENDO
Keyword(s):  
Blood Pressure ◽  
Life Span ◽  
Spontaneously Hypertensive Rats ◽  
Cerebral Stroke ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals Prevention of cerebral stroke in salt loaded stroke-prone spontaneously hypertensive rats with severe hypertension by SM-6586

1992 ◽  
Vol 58 ◽  
pp. 288
Author(s):  
Takashi Maniwa ◽  
Tsuyoshi Noguchi ◽  
Akira Miyagishi ◽  
Youichi Hara
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Severe Hypertension ◽  
Cerebral Stroke ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals Vibroacustic microvibrations enhance kidney blood supply, glomerular filtration and glutathione peroxidase activity in spontaneously hypertensive rats

2015 ◽  
Vol 34 (01) ◽  
pp. 89-94
Author(s):  
Zoran Miloradović ◽  
Nevena Mihailović-Stanojević ◽  
Đurđica Jovović ◽  
Milan Ivanov ◽  
Una J. Vajić ◽  
...  
Keyword(s):  
Glomerular Filtration ◽  
Blood Supply ◽  
Peroxidase Activity ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals Prevention of cerebral stroke, cardiac and vascular hypertrophy in stroke-prone spontaneously hypertensive rats by arotinolol (Report I)

1988 ◽  
Vol 46 ◽  
pp. 263
Author(s):  
Takashi Maniwa ◽  
Akira Miyagishi ◽  
Tsuyoshi Noguchi ◽  
Takashi Miyano ◽  
Youichi Hara
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Cerebral Stroke ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Vascular Hypertrophy
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