scholarly journals Enzymatic synthesis of nucleoside antibiotics. Part IV. Microbial synthesis of purine 2'-amino-2'-deoxyribosides.

1985 ◽  
Vol 49 (9) ◽  
pp. 2711-2717 ◽  
Author(s):  
Takashi UTAGAWA ◽  
Hirokazu MORISAWA ◽  
Shigeru YAMANAKA ◽  
Akihiro YAMAZAKI ◽  
Yoshio HIROSE
Keyword(s):  
Enzymatic Synthesis ◽  
Microbial Synthesis ◽  
Nucleoside Antibiotics

scholarly journals Enzymatic synthesis of nucleoside antibiotics. Part II. Microbial synthesis of purine arabinosides and their biological activity.

1985 ◽  
Vol 49 (7) ◽  
pp. 2167-2171 ◽  
Author(s):  
Takashi UTAGAWA ◽  
Hirokazu MORISAWA ◽  
Shigeru YAMANAKA ◽  
Akihiro YAMAZAKI ◽  
Fumihiro YOSHINAGA ◽  
...  
Keyword(s):  
Biological Activity ◽  
Enzymatic Synthesis ◽  
Microbial Synthesis ◽  
Nucleoside Antibiotics

scholarly journals Enzymatic Synthesis of the Ribosylated Glycyl-Uridine Disaccharide Core of Peptidyl Nucleoside Antibiotics

2018 ◽  
Vol 83 (13) ◽  
pp. 7239-7249 ◽  
Author(s):  
Zheng Cui ◽  
Xiaodong Liu ◽  
Jonathan Overbay ◽  
Wenlong Cai ◽  
Xiachang Wang ◽  
...  
Keyword(s):  
Enzymatic Synthesis ◽  
Nucleoside Antibiotics

scholarly journals Enzymatic synthesis of nucleoside antibiotics. Part I. Microbiological synthesis of adenine arabinoside.

1985 ◽  
Vol 49 (4) ◽  
pp. 1053-1058 ◽  
Author(s):  
Takashi UTAGAWA ◽  
Hirokazu MORISAWA ◽  
Fumihiro YOSHINAGA ◽  
Akihiro YAMAZAKI ◽  
Koji MITSUGI ◽  
...  
Keyword(s):  
Enzymatic Synthesis ◽  
Microbiological Synthesis ◽  
Nucleoside Antibiotics ◽  
Adenine Arabinoside

scholarly journals Enzymatic synthesis of nucleoside antibiotics. Part III. Mechanism of purine arabinoside synthesis by bacterial transarabinosylation reaction.

1985 ◽  
Vol 49 (8) ◽  
pp. 2425-2430 ◽  
Author(s):  
Takashi UTAGAWA ◽  
Hirokazu MORISAWA ◽  
Shigeru YAMANAKA ◽  
Akihiro YAMAZAKI ◽  
Fumihiro YOSHINAGA ◽  
...  
Keyword(s):  
Enzymatic Synthesis ◽  
Nucleoside Antibiotics

scholarly journals Enzymatic synthesis of nucleoside antibiotics. Part V. Properties of nucleoside phosphorylase from Enterobacter aerogenes.

1985 ◽  
Vol 49 (11) ◽  
pp. 3239-3246 ◽  
Author(s):  
Takashi UTAGAWA ◽  
Hirokazu MORISAWA ◽  
Shigeru YAMANAKA ◽  
Akihiro YAMAZAKI ◽  
Fumihiro YOSHINAGA ◽  
...  
Keyword(s):  
Enzymatic Synthesis ◽  
Enterobacter Aerogenes ◽  
Nucleoside Phosphorylase ◽  
Nucleoside Antibiotics

Enzymatic Synthesis of Enantiomerically Pure Chiral Synthons: Lipase-Catalyzed Resolution of (R/S, 4E)-2-Methyl-4-hexen-l-ol

Synlett ◽  
1991 ◽  
Vol 1991 (04) ◽  
pp. 310-312
Author(s):  
Patrizia Ferraboschi ◽  
Daria Brembilla ◽  
Paride Grisenti ◽  
Enzo Santaniello
Keyword(s):  
Enzymatic Synthesis ◽  
Enantiomerically Pure

A common precursor to both prebiotic and biological pathways to RNA nucleotides

2018 ◽  
Author(s):  
Andrea Pérez-Villa ◽  
Thomas Georgelin ◽  
Jean-François Lambert ◽  
Marie-Christine Maurel ◽  
François Guyot ◽  
...  
Keyword(s):  
Enzymatic Synthesis ◽  
De Novo ◽  
Life Forms ◽  
Hydrothermal Conditions ◽  
Modern Life ◽  
Ab Initio Simulations ◽  
Spontaneous Formation ◽  
Common Precursor ◽  
Open Issue ◽  
Anomeric Carbon

Understanding the mechanism of spontaneous formation of ribonucleotides under realistic prebiotic conditions is a key open issue of origins-of-life research. In cells, <i>de novo</i> and salvage nucleotide enzymatic synthesis combines 5-phospho-α -D-ribose-1-diphosphate ( α-PRPP) and nucleobases. Interestingly, these reactants are also known as prebiotically plausible compounds. Combining ab initio simulations with mass spectrometry experiments, we compellingly demonstrate that nucleobases and α -PRPP spontaneously combine, through the same facile mechanism, forming both purine and pyrimidine ribonucleotides, under mild hydrothermal conditions. Surprisingly, this mechanism is very similar to the biological one, and yields ribonucleotides with the same anomeric carbon chirality as in biological systems. These results suggest that natural selection might have optimized – through enzymes – a pre-existing ribonucleotide formation mechanism, carrying it forward to modern life forms.

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