scholarly journals Chemical studies on optically active natural products with interesting biological activities.

1987 ◽  
Vol 61 (8) ◽  
pp. 925-930 ◽  
Author(s):  
Takeyoshi SUGIYAMA
Keyword(s):  
Natural Products ◽  
Biological Activities ◽  
Optically Active ◽  
Chemical Studies ◽  
Active Natural

scholarly journals Palladium-Catalyzed Coupling Reactions on Functionalized 2-Trifluoromethyl-4-chromenone Scaffolds: Synthesis of Highly Functionalized Trifluoromethyl Heterocycles

Synthesis ◽  
2018 ◽  
Vol 51 (06) ◽  
pp. 1342-1352 ◽  
Author(s):  
Javier Izquierdo ◽  
Atul Jain ◽  
Sarki Abdulkadir ◽  
Gary Schiltz
Keyword(s):  
Natural Products ◽  
Organic Synthesis ◽  
Biological Activities ◽  
Structural Complexity ◽  
Biologically Active ◽  
Coupling Reactions ◽  
Trifluoromethyl Group ◽  
Palladium Catalyzed ◽  
Active Natural

The chromenone core is an ubiquitous group in biologically active natural products and has been extensively used in organic synthesis. Fluorine-derived compounds, including those with a trifluoromethyl group (CF3), have shown enhanced biological activities in numerous pharmaceuticals compared with their non-fluorinated analogues. 2-Trifluoromethylchromenones can be readily functionalized at the 8- and 7-positions, providing chromenones cores of high structural complexity, which are excellent precursors for numerous trifluoromethyl heterocycles.

ChemInform Abstract: Application of Butane-2,3-diacetals in the Synthesis of Optically Active Natural Products

ChemInform ◽  
2014 ◽  
Vol 46 (3) ◽  
pp. no-no
Author(s):  
Weronika Waclawczyk-Biedron ◽  
Adam Drop ◽  
Bozena Frackowiak-Wojtasek
Keyword(s):  
Natural Products ◽  
Optically Active ◽  
Active Natural

Enantioselective constructions of quaternary carbons and their application to the asymmetric total syntheses of fredericamycin A and discorhabdin A

2007 ◽  
Vol 79 (4) ◽  
pp. 701-713 ◽  
Author(s):  
Yasuyuki Kita ◽  
Hiromichi Fujioka
Keyword(s):  
Natural Products ◽  
Optically Active ◽  
Biologically Active ◽  
Hypervalent Iodine ◽  
Total Syntheses ◽  
Carbon Centers ◽  
Phenol Derivatives ◽  
Fredericamycin A ◽  
Active Natural ◽  
Quaternary Carbons

An efficient enantioselective construction of quaternary carbons including spiro carbons is an area of intense interest due to the importance of these units as components of biologically active natural products. Prominent methods are presented for the synthesis of chiral, nonracemic quaternary carbon centers by (i) stereospecific rearrangement of optically active epoxides, (ii) enzyme-catalyzed resolution, and (iii) hypervalent iodine reagent-induced ipso-substitution of para-substituted phenol derivatives. These methods were applied to the total syntheses of fredericamycin A and discorhabdin A.

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