scholarly journals HIV/AIDS Clinical Trials: A Statistical Review

2006 ◽  
Vol 5 (2) ◽  
pp. 71-85
Author(s):  
Annie Sumithri Soans ◽  
Nagaraja Rao Chillale ◽  
T. Srivenkataramana
Keyword(s):  
Infectious Disease ◽  
Clinical Trials ◽  
Bayesian Analysis ◽  
Incomplete Data ◽  
Meta Analysis ◽  
Economic Stability ◽  
Statistical Review ◽  
The World ◽  
Aids Clinical Trials ◽  
Hiv Aids

The HIV pandemic has grown to become one of the greatest infectious disease threats, to human health and to socio-economic stability that the world has ever encountered.It is imperative that the epidemic is controlled as rapidly as possible through prevention of new infections.Carefully conducted clinical trials are the fastest and safest way to find treatments that work in people to improve health.When the objectives or the endpoints of clinical trials for HIV/AIDS are carefully defined then Statistics will be very useful not only in designing the trial and formulating hypothesis but also in providing guidance in the analysis of the data on completion of the trial and to enhance the credibility of the results.This article mainly reviews the analysis of HIV/AIDS clinical trials.Concepts such as meta-analysis,analysis in the case of incomplete data and Bayesian analysis in the context of HIV/AIDS have also been covered.

scholarly journals Community-Researcher Partnerships at NIAID HIV/AIDS Clinical Trials Sites: Insights for Evaluation and Enhancement

2012 ◽  
Vol 6 (3) ◽  
pp. 311-320 ◽  
Author(s):  
Jonathan M. Kagan ◽  
Scott R. Rosas ◽  
Rona L. Siskind ◽  
Russell D. Campbell ◽  
Daniel Gondwe ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Aids Clinical Trials ◽  
Hiv Aids

Use of Complementary Medicine by Adult Patients Participating in HIV/AIDS Clinical Trials

2000 ◽  
Vol 6 (5) ◽  
pp. 415-422 ◽  
Author(s):  
Andrew Sparber ◽  
Jacqueline C. Wootton ◽  
Larry Bauer ◽  
Gregory Curt ◽  
David Eisenberg ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Complementary Medicine ◽  
Adult Patients ◽  
Aids Clinical Trials ◽  
Hiv Aids

scholarly journals How Researchers Define Vulnerable Populations in HIV/AIDS Clinical Trials

2010 ◽  
Vol 14 (6) ◽  
pp. 1313-1319 ◽  
Author(s):  
Sohini Sengupta ◽  
Bernard Lo ◽  
Ronald P. Strauss ◽  
Joseph Eron ◽  
Allen L. Gifford
Keyword(s):  
Clinical Trials ◽  
Vulnerable Populations ◽  
Aids Clinical Trials ◽  
Hiv Aids

scholarly journals The efficacy and safety of interferons for the treatment of patients with COVID-19: protocol for systematic review and meta-analysis of controlled trials

2021 ◽  
Author(s):  
Afsaneh Noormandi ◽  
Mohammad Fathalipour ◽  
Reza Daryabeygi-Khotbehsara ◽  
Soheil Hassanipour
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Meta Analysis ◽  
World Health ◽  
Controlled Trials ◽  
Efficacy And Safety ◽  
Global Pandemic ◽  
The World ◽  
Health Organization ◽  
Time Of Administration

Background and objective: COVID-19 has since been declared a global pandemic by the World Health Organization (WHO), infecting millions worldwide. The use of Interferon (INF) subtypes previously examined in the treatment of SARS and MERS is also being initiated in some clinical trials. Although different clinical trials were evaluated IFNs in the treatment of COVID-19, their efficacy and safety remain unknown. Therefore, this study aims to systematically assess IFNs efficacy and safety in treating patients with COVID-19. Methods: The protocol has been registered in the PROSPERO International Prospective Register (CRD42020200643) on 24 July 2020. This protocol has been arranged according to the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) 2015 checklist. Discussion: Due to lack of approved medication for the covid-19 treatment and also various mutations of this virus, evaluated the efficacy and safety of medications by various studies could help for finding treatments with high effectiveness. IFNs are one of the medications that have been administered in covid-19 infection.  Moreover, the best time of administration and dose of this medication was unknown. Although meta-analysis is a potent source for assessing the accuracy of subjects, heterogeneity of articles is a potent limitation of our work.

Implementing Community Involvement in National Institutes of Health (NIH) HIV/AIDS Clinical Trials Networks

2014 ◽  
Vol 30 (S1) ◽  
pp. A107-A107
Author(s):  
Rona Siskind ◽  
Neetha S. Morar ◽  
Russell D. Campbell ◽  
Jeffrey Schouten
Keyword(s):  
Clinical Trials ◽  
Community Involvement ◽  
National Institutes Of Health ◽  
Aids Clinical Trials ◽  
Hiv Aids

scholarly journals Engaging Transgender People in NIH-Funded HIV/AIDS Clinical Trials Research

2016 ◽  
Vol 72 ◽  
pp. S243-S247 ◽  
Author(s):  
Rona L. Siskind ◽  
Michele Andrasik ◽  
Shelly T. Karuna ◽  
Gail B. Broder ◽  
Clare Collins ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Transgender People ◽  
Aids Clinical Trials ◽  
Hiv Aids

scholarly journals Evaluating protocol lifecycle time intervals in HIV/AIDS clinical trials

2014 ◽  
Vol 11 (5) ◽  
pp. 553-559 ◽  
Author(s):  
Scott R Rosas ◽  
Jeffrey T Schouten ◽  
Dennis Dixon ◽  
Suresh Varghese ◽  
Marie T Cope ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Time Intervals ◽  
Aids Clinical Trials ◽  
Hiv Aids

Compensation for Research-Related Injury in NIH-Sponsored HIV/AIDS Clinical Trials in Africa

2013 ◽  
Vol 8 (1) ◽  
pp. 45-54 ◽  
Author(s):  
Nicole Mamotte ◽  
Douglas Wassenaar ◽  
Nivedhna Singh
Keyword(s):  
Clinical Trials ◽  
Aids Clinical Trials ◽  
Hiv Aids
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