scholarly journals Erratum: Population Pharmacokinetic Analysis of Metformin Administered as Fixed-Dose Combination in Korean Healthy Adults

2018 ◽  
Vol 26 (3) ◽  
pp. 143
Author(s):  
Suein Choi ◽  
Sangil Jeon ◽  
Seunghoon Han ◽  
Dong-Seok Yim
Keyword(s):  
Population Pharmacokinetic Analysis ◽  
Healthy Adults ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Pharmacokinetic Analysis ◽  
Population Pharmacokinetic ◽  
Dose Combination

Fixed dose rivaroxaban can be used in extremes of bodyweight: A population pharmacokinetic analysis ‐ Reply to Jacobs & Ryan comment

2021 ◽  
Vol 19 (3) ◽  
pp. 872-873
Author(s):  
Victoria Speed ◽  
Lara N. Roberts ◽  
Roopen Arya ◽  
Jignesh P. Patel
Keyword(s):  
Population Pharmacokinetic Analysis ◽  
Fixed Dose ◽  
Pharmacokinetic Analysis ◽  
Population Pharmacokinetic

scholarly journals Is Dosing of Ethambutol as Part of a Fixed-Dose Combination Product Optimal for Mechanically Ventilated ICU Patients with Tuberculosis? A Population Pharmacokinetic Study

Antibiotics ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1559
Author(s):  
Francisco Beraldi-Magalhaes ◽  
Suzanne L. Parker ◽  
Cristina Sanches ◽  
Leandro Sousa Garcia ◽  
Brenda Karoline Souza Carvalho ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
Oral Absorption ◽  
Compartment Model ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Population Pharmacokinetic ◽  
Icu Patients ◽  
Population Pharmacokinetic Study ◽  
Dosing Regimens ◽  
Dose Combination

Background: Tuberculosis (TB) patients admitted to intensive care units (ICU) have high mortality rates. It is uncertain whether the pharmacokinetics of first-line TB drugs in ICU patients are different from outpatients. This study aims to compare the pharmacokinetics of oral ethambutol in TB patients in ICU versus TB outpatients and to determine whether contemporary dosing regimens achieve therapeutic exposures. Methods: A prospective population pharmacokinetic study of ethambutol was performed in Amazonas State, Brazil. Probability of target attainment was determined using AUC/MIC > 11.9 and Cmax/MIC > 0.48 values. Optimized dosing regimens were simulated at steady state. Results: Ten ICU patients and 20 outpatients were recruited. Ethambutol pharmacokinetics were best described using a two-compartment model with first-order oral absorption. Neither ICU patients nor outpatients consistently achieved optimal ethambutol exposures. The absorption rate for ethambutol was 2-times higher in ICU patients (p < 0.05). Mean bioavailability for ICU patients was >5-times higher than outpatients (p < 0.0001). Clearance and volume of distribution were 93% (p < 0.0001) and 53% (p = 0.002) lower in ICU patients, respectively. Conclusions: ICU patients displayed significantly different pharmacokinetics for an oral fixed-dose combination administration of ethambutol compared to outpatients, and neither patient group consistently achieved pre-defined therapeutic exposures.

Phase I dose-escalation study and population pharmacokinetic analysis of fixed dose rate gemcitabine plus carboplatin as second-line therapy in patients with ovarian cancer

2013 ◽  
Vol 130 (3) ◽  
pp. 511-517 ◽  
Author(s):  
Suzanne Leijen ◽  
Stephan A. Veltkamp ◽  
Alwin D.R. Huitema ◽  
E. van Werkhoven ◽  
Jos H. Beijnen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Population Pharmacokinetic Analysis ◽  
Fixed Dose ◽  
Pharmacokinetic Analysis ◽  
Population Pharmacokinetic ◽  
Second Line ◽  
Second Line Therapy ◽  
Dose Escalation Study ◽  
Line Therapy ◽  
Fixed Dose Rate

scholarly journals Fixed Dose of Cemiplimab in Patients with Advanced Malignancies Based on Population Pharmacokinetic Analysis

2021 ◽  
Author(s):  
Anne J. Paccaly ◽  
Michael R. Migden ◽  
Kyriakos P. Papadopoulos ◽  
Feng Yang ◽  
John D. Davis ◽  
...  
Keyword(s):  
Population Pharmacokinetic Analysis ◽  
Fixed Dose ◽  
Pharmacokinetic Analysis ◽  
Population Pharmacokinetic ◽  
Advanced Malignancies

scholarly journals A Population Pharmacokinetic Analysis of Dextroamphetamine in the Plasma and Hair of Healthy Adults

2015 ◽  
Vol 35 (10) ◽  
pp. 633-643 ◽  
Author(s):  
Jessica K. Roberts ◽  
Sarah F. Cook ◽  
Chris Stockmann ◽  
Douglas E. Rollins ◽  
Diana G. Wilkins ◽  
...  
Keyword(s):  
Population Pharmacokinetic Analysis ◽  
Healthy Adults ◽  
Pharmacokinetic Analysis ◽  
Population Pharmacokinetic
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