scholarly journals The Use of Thalidomide in Severe Refractory Anaemia Due to Gastric Antral Vascular Ectasia (GAVE) in Cirrhosis?

2020 ◽  
Author(s):  
Marcelo Aveiro ◽  
Tatiana Rodrigues ◽  
Tiago Rabadão ◽  
Filipa Ferreira ◽  
Mariana Teixeira ◽  
...  
Keyword(s):  
Upper Gastrointestinal Bleeding ◽  
Argon Plasma Coagulation ◽  
Argon Plasma ◽  
High Recurrence Rate ◽  
Gastric Antral Vascular Ectasia ◽  
Refractory Anaemia ◽  
First Line ◽  
Vascular Ectasia ◽  
Recent Diagnosis ◽  
Upper Gastrointestinal

Gastric antral vascular ectasia (GAVE) is a rare cause of upper gastrointestinal bleeding associated with cirrhosis. The first-line treatment is endoscopic therapy with argon plasma coagulation (APC). There is a high recurrence rate, but some evidence suggests that thalidomide could play an important role in controlling refractory anaemia due to GAVE. The authors present the case of a cirrhotic patient with a recent diagnosis of GAVE, who underwent multiple endoscopic treatments and blood transfusions because of haematemesis. The patient started thalidomide and 6 months later, there was no recurrence of haematemesis and haemoglobin levels were stable, with no reported adverse effects.

scholarly journals Gastric antral vascular ectasia: a case report

2014 ◽  
Vol 4 (2) ◽  
pp. 130-133 ◽  
Author(s):  
Amir Cehajic ◽  
Denis Mackic ◽  
Elvira Dzambasovic ◽  
Nijaz Tucakovic ◽  
Aida Mujakovic ◽  
...  
Keyword(s):  
Beta Blockers ◽  
Argon Plasma Coagulation ◽  
Argon Plasma ◽  
Endoscopic Examination ◽  
Chronic Illnesses ◽  
Gastrointestinal System ◽  
Gastric Antral Vascular Ectasia ◽  
Iron Supplements ◽  
Vascular Ectasia ◽  
Upper Gastrointestinal

Gastric antral vascular ectasia is a vascular gastric malformation which represents a rare cause of upper gastrointestinal system bleeding. It is usually presented with a significant anemia and it is diagnosed with an endoscopic examination of the upper gastrointestinal system. It is often associated with other chronic illnesses such as liver cirrhosis, sclerodermia, diabetes mellitus and arterial hypertension. It is treated symptomatically in terms of anemia correction with blood transfusions and iron supplements, proton pump inhibitors, beta-blockers and endoscopic procedures such as argon plasma coagulation which currently represents the treatment of choice in Sy. GAVE cases.

scholarly journals Endoscopic treatment for gastric antral vascular ectasia

2021 ◽  
Vol 12 ◽  
pp. 204062232110396
Author(s):  
Mengyuan Peng ◽  
Xiaozhong Guo ◽  
Fangfang Yi ◽  
Xiaodong Shao ◽  
Le Wang ◽  
...  
Keyword(s):  
Adverse Events ◽  
Endoscopic Treatment ◽  
Argon Plasma Coagulation ◽  
Argon Plasma ◽  
High Recurrence Rate ◽  
Gastric Antral Vascular Ectasia ◽  
Success Rates ◽  
Recurrence Rates ◽  
Vascular Ectasia ◽  
Major Treatment

Gastric antral vascular ectasia (GAVE) is one of the uncommon causes of upper gastrointestinal bleeding. Major treatment of GAVE includes pharmacotherapy, endoscopy, and surgery. The efficacy and safety of pharmacotherapy have not been sufficiently confirmed; and surgery is just considered when conservative treatment is ineffective. By comparison, endoscopy is a common treatment option for GAVE. This paper reviews the currently used endoscopic approaches for GAVE, mainly including argon plasma coagulation (APC), radiofrequency ablation (RFA), and endoscopic band ligation (EBL). It also summarizes their efficacy and procedure-related adverse events. The endoscopic success rate of APC is 40–100%; however, APC needs several treatment sessions, with a high recurrence rate of 10–78.9%. The endoscopic success rates of RFA and EBL are 90–100% and 77.8–100%, respectively; and their recurrence rates are 21.4–33.3% and 8.3–48.1%, respectively. Hyperplastic gastric polyps and sepsis are major adverse events of APC and RFA; and Mallory–Weiss syndrome is occasionally observed after APC. Adverse events of EBL are rare and mild, such as nausea, vomiting, esophageal or abdominal pain, and hyperplastic polyps. APC is often considered as the first-line choice of endoscopic treatment for GAVE. RFA and EBL have been increasingly used as alternatives in patients with refractory GAVE. A high recurrence of GAVE after endoscopic treatment should be fully recognized and cautiously managed by follow-up endoscopy. In future, a head-to-head comparison of different endoscopic approaches for GAVE is warranted.

Refractory Gave Treated with Radiofrequency: Two Cases of Complete Response

2018 ◽  
pp. 1-3
Keyword(s):  
Upper Gastrointestinal Bleeding ◽  
Argon Plasma Coagulation ◽  
Argon Plasma ◽  
Standard Of Care ◽  
Complete Response ◽  
Blood Transfusions ◽  
Gastric Antral Vascular Ectasia ◽  
Plasma Coagulation ◽  
Endoscopic Band Ligation ◽  
Upper Gastrointestinal

Gastric antral vascular ectasia (GAVE) is an uncommon cause of upper gastrointestinal bleeding. Up to date, standard of care of GAVE is endoscopic treatment with argon plasma coagulation (APC) or endoscopic band ligation (EBL). Despite good technical efficacy of these techniques, approximately two third of patients remain dependent on blood transfusions after therapy. One of the emerging and more promising endoscopic treatments for GAVE is radiofrequency ablation (RFA) with focal catheters (e.g. HALO90 and HALOULTRA).

Endoscopic mucosal resection for recurrent gastric antral vascular ectasia

VASA ◽  
2008 ◽  
Vol 37 (3) ◽  
pp. 289-292 ◽  
Author(s):  
Katsinelos ◽  
Chatzimavroudis ◽  
Katsinelos ◽  
Panagiotopoulou ◽  
Kotakidou ◽  
...  
Keyword(s):  
Endoscopic Mucosal Resection ◽  
Argon Plasma Coagulation ◽  
Argon Plasma ◽  
Deficiency Anemia ◽  
Gastric Antral Vascular Ectasia ◽  
Therapeutic Approaches ◽  
Plasma Coagulation ◽  
Vascular Ectasia ◽  
Mucosal Resection ◽  
First Case

Gastric antral vascular ectasia (GAVE) is an overt or occult source of gastrointestinal bleeding. Despite several therapeutic approaches have been successfully tested for preventing chronic bleeding, some patients present recurrence of GAVE lesions. To the best of our knowledge, we report the first case, of a 86-year-old woman who presented severe iron-deficiency anemia due to GAVE and showed recurrence of GAVE lesion despite the intensive argon plasma coagulation treatment. We performed endoscopic mucosal resection of bleeding GAVE with resolution of anemia.

scholarly journals Hyperplastic gastric polyps after argon plasma coagulation treatment of gastric antral vascular ectasia (GAVE)

Endoscopy ◽  
2007 ◽  
Vol 39 (S 1) ◽  
pp. E320-E320 ◽  
Author(s):  
J. Baudet ◽  
H. Salata ◽  
M. Soler ◽  
V. Castro ◽  
D. Díaz-Bethencourt ◽  
...  
Keyword(s):  
Argon Plasma Coagulation ◽  
Argon Plasma ◽  
Gastric Antral Vascular Ectasia ◽  
Plasma Coagulation ◽  
Vascular Ectasia ◽  
Gastric Polyps
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