scholarly journals Immunohistochemical analysis for acetylcholinesterase and choline acetyltransferase in mouse cerebral cortex after traumatic brain injury

2020 ◽  
Vol 82 (6) ◽  
pp. 827-835
Author(s):  
Tomoyo HORIO ◽  
Aisa OZAWA ◽  
Junichi KAMIIE ◽  
Motoharu SAKAUE
Keyword(s):  
Traumatic Brain Injury ◽  
Cerebral Cortex ◽  
Brain Injury ◽  
Choline Acetyltransferase ◽  
Immunohistochemical Analysis ◽  
Mouse Cerebral Cortex

scholarly journals Web Application for Quantification of Traumatic Brain Injury-Induced Cortical Lesions in Adult Mice

2019 ◽  
Vol 18 (2) ◽  
pp. 307-317
Author(s):  
Robert Ciszek ◽  
Pedro Andrade ◽  
Jesse Tapiala ◽  
Asla Pitkänen ◽  
Xavier Ekolle Ndode-Ekane
Keyword(s):  
Traumatic Brain Injury ◽  
Cerebral Cortex ◽  
Brain Injury ◽  
Web Application ◽  
Cortical Lesion ◽  
Lesion Area ◽  
Manual Method ◽  
Automated Method ◽  
Mouse Cerebral Cortex ◽  
The Web

AbstractDisabilities resulting from traumatic brain injury (TBI) strongly correlate with the cytoarchitectonic part of the brain damaged, lesion area, and type of lesion. We developed a Web application to estimate the location of the lesion on mouse cerebral cortex caused by TBI induced by lateral fluid-percussion injury. The application unfolds user-determined TBI lesion measurements, e.g., from histologic sections to a reference template, and estimates the total lesion area, including the percentage of cortex damaged in different cytoarchitectural cortical regions. The resulting lesion can be visualized on a two-dimensional map of mouse cerebral cortex. The application also visualizes the development of the lesion over time when measurements from multiple time points are available. The web application was validated by comparing its performance to the manual method. The total area of the cortical lesion was similar between the manual (9.19 ± 0.66 mm2, range 4.25–14.93 mm2) and the automated analysis (9.27 ± 0.66 mm2, range 4.50–15.10 mm2) (p = 0.938). The results of the manual and automated analyses were strongly correlated (r = 0.999, p < 0.0001, Pearson correlation). The lesion localized in the same cytoarchitectonic regions when the unfolded map from the automated method was superimposed onto the map obtained using the manual method. The Web application-automated method is faster than the manual method in generating unfolded cortical lesion maps. The accuracy of the presented automated method in determining the anteroposterior level and outlining the lesion is equal to or greater than that of the manual method. Our application provides a novel tool for accurately quantifying and visualizing TBI lesions on mouse cerebral cortex.

Significant changes in circular RNA in the mouse cerebral cortex around an injury site after traumatic brain injury

2019 ◽  
Vol 313 ◽  
pp. 37-48 ◽  
Author(s):  
Zhihao Chen ◽  
Hong Wang ◽  
Jianjun Zhong ◽  
Junqing Yang ◽  
Rami Darwazeh ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Cerebral Cortex ◽  
Brain Injury ◽  
Circular Rna ◽  
Injury Site ◽  
Mouse Cerebral Cortex

scholarly journals Biomechanics of Traumatic Brain Injury: Influences of the Morphologic Heterogeneities of the Cerebral Cortex

2008 ◽  
Vol 36 (7) ◽  
pp. 1203-1215 ◽  
Author(s):  
R.J.H. Cloots ◽  
H.M.T. Gervaise ◽  
J.A.W. van Dommelen ◽  
M.G.D. Geers
Keyword(s):  
Traumatic Brain Injury ◽  
Cerebral Cortex ◽  
Brain Injury

Development of a de novo arteriovenous malformation after severe traumatic brain injury

2014 ◽  
Vol 14 (4) ◽  
pp. 418-420 ◽  
Author(s):  
Brandon A. Miller ◽  
David I. Bass ◽  
Joshua J. Chern
Keyword(s):  
Traumatic Brain Injury ◽  
Cerebral Cortex ◽  
Brain Injury ◽  
Arteriovenous Malformation ◽  
Severe Traumatic Brain Injury ◽  
Arteriovenous Malformations ◽  
De Novo ◽  
First Report ◽  
Congenital Lesions

Arteriovenous malformations (AVMs) are typically considered congenital lesions, although there is growing evidence for de novo formation of these lesions as well. The authors present the case of an AVM in the same cerebral cortex that had been affected by a severe traumatic brain injury (TBI) more than 6 years earlier. To the best of the authors' knowledge, this is the first report attributing the formation of an AVM directly to TBI.

Temporal Lobe Syndromes

2020 ◽  
pp. 122-135
Author(s):  
Arpit Parmar ◽  
G. S. Kaloiya ◽  
Harsimarpreet Kaur
Keyword(s):  
Traumatic Brain Injury ◽  
Cerebral Cortex ◽  
Brain Injury ◽  
Middle Cerebral Artery ◽  
Temporal Lobe ◽  
Cerebral Artery ◽  
Left Temporal Lobe ◽  
Temporal Lobes ◽  
Functional Aspects ◽  
The Common

Temporal lobes are one of the four major lobes of the cerebral cortex and perform a complex array of interrelated functions. They play an important role in various day-to-day functioning. The common pathologies leading to isolated temporal lobe dysfunction are infarction (of the middle cerebral artery), hemorrhage, seizures, tumors, encephalitis, and traumatic brain injury. Temporal lobe syndromes include a wide array of various neurological (Kluver-Bucy syndrome, Geschwind Gastaut syndrome, etc.), elementary (e.g., vertiginous syndromes, hallucinations, etc.), neuropsychiatric (e.g., anxiety, agitation, aggression, etc.), and cognitive (e.g., Korsakoff amnesia, cortical deafness, etc.) disorders. The presentation depends on a multitude of factors including involvement of dominant or non-dominant lobe. Left temporal lobe involvement usually leads to various forms of aphasia while right side involvement leads to more covert and varied syndromes. In this chapter, the authors discuss the anatomy of the temporal lobe, its functional aspects, and various syndromes of temporal lobe dysfunction.

Increased expression of ferritin in cerebral cortex after human traumatic brain injury

2012 ◽  
Vol 34 (7) ◽  
pp. 1173-1180 ◽  
Author(s):  
Huan-Dong Liu ◽  
Wei Li ◽  
Zhen-Rui Chen ◽  
Meng-Liang Zhou ◽  
Zong Zhuang ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Cerebral Cortex ◽  
Brain Injury
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