scholarly journals Isolation of Serotype 2 Marek's Disease Virus from a Cell Line of Avian Lymphoid Leukosis.

1998 ◽  
Vol 60 (2) ◽  
pp. 143-148 ◽  
Author(s):  
Hiroshi HIHARA ◽  
Kunitoshi IMAI ◽  
Kenji TSUKAMOTO ◽  
Kikuyasu NAKAMURA
Keyword(s):  
Cell Line ◽  
Disease Virus ◽  
Marek's Disease Virus ◽  
Marek's Disease ◽  
Marek’S Disease Virus ◽  
Marek’S Disease ◽  
Lymphoid Leukosis ◽  
A Cell

scholarly journals Development of a Sustainable Chick Cell Line Infected with Marek's Disease Virus

Virology ◽  
1995 ◽  
Vol 214 (2) ◽  
pp. 541-549 ◽  
Author(s):  
AMIN ABUJOUB ◽  
PAUL M. COUSSENS
Keyword(s):  
Cell Line ◽  
Disease Virus ◽  
Marek's Disease Virus ◽  
Marek's Disease ◽  
Marek’S Disease Virus ◽  
Marek’S Disease

Pathogenicity of a Quail (Coturnix coturnix japonica)-Derived Marek's Disease Virus Rescued from the QT35 Cell Line

2010 ◽  
Vol 54 (1) ◽  
pp. 126-130 ◽  
Author(s):  
Kelly L. Crucillo ◽  
Karel A. Schat ◽  
Ynte H. Schukken ◽  
Amy E. Brown ◽  
Patricia S. Wakenell
Keyword(s):  
Cell Line ◽  
Disease Virus ◽  
Marek's Disease Virus ◽  
Marek's Disease ◽  
Coturnix Japonica ◽  
Marek’S Disease Virus ◽  
Marek’S Disease ◽  
Coturnix Coturnix Japonica ◽  
Coturnix Coturnix

Efficacy and safety of cell associated vaccines against Marek's disease virus grown in a continuous cell line from chickens

Vaccine ◽  
2008 ◽  
Vol 26 (44) ◽  
pp. 5595-5600 ◽  
Author(s):  
Harm Geerligs ◽  
Sandra Quanz ◽  
Brenda Suurland ◽  
Ine E.M. Spijkers ◽  
Jeff Rodenberg ◽  
...  
Keyword(s):  
Cell Line ◽  
Disease Virus ◽  
Marek's Disease Virus ◽  
Marek's Disease ◽  
Continuous Cell Line ◽  
Marek’S Disease Virus ◽  
Marek’S Disease ◽  
Efficacy And Safety

scholarly journals Marek's disease virus undergoes complete morphogenesis after reactivation in a T-lymphoblastoid cell line transformed by recombinant fluorescent marker virus

2016 ◽  
Vol 97 (2) ◽  
pp. 480-486 ◽  
Author(s):  
Caroline Denesvre ◽  
Sylvie Rémy ◽  
Laetitia Trapp-Fragnet ◽  
Lorraine P. Smith ◽  
Sonia Georgeault ◽  
...  
Keyword(s):  
Cell Line ◽  
Disease Virus ◽  
Lymphoblastoid Cell Line ◽  
Marek's Disease Virus ◽  
Marek's Disease ◽  
Marek’S Disease Virus ◽  
Marek’S Disease ◽  
Fluorescent Marker ◽  
Marker Virus

scholarly journals The RNA Subunit of Telomerase Is Encoded by Marek's Disease Virus

2003 ◽  
Vol 77 (10) ◽  
pp. 5985-5996 ◽  
Author(s):  
Laëtitia Fragnet ◽  
Maria A. Blasco ◽  
Wolfram Klapper ◽  
Denis Rasschaert
Keyword(s):  
Cell Line ◽  
Disease Virus ◽  
Telomerase Activity ◽  
Marek's Disease Virus ◽  
Marek's Disease ◽  
Marek’S Disease Virus ◽  
Marek’S Disease ◽  
Blood Leukocytes ◽  
Potential Implication

ABSTRACT Marek's disease virus (MDV) is a herpesvirus of chickens that induces T lymphomas and tumors within 4 to 5 weeks of infection. Although the ability of MDV to induce tumors was demonstrated many years ago and although a number of viral oncogenic proteins have been identified, the mechanism by which the MDV is implicated in tumorigenesis is still unknown. We report the identification of a virus-encoded RNA telomerase subunit (vTR) within the genome of MDV. This gene is found in the genomic DNA of the oncogenic MDV strains, whereas it is not carried by the nononcogenic MDV strains. The vTR sequence exhibits 88% sequence identity with the chicken gene (cTR). Our functional analysis suggests that this telomerase RNA can reconstitute telomerase activity in a heterologous system (the knockout murine TR−/− cell line) by interacting with the telomerase protein component encoded by the host cell. We have also demonstrated that the vTR promoter region is efficient whatever the species of cell line considered and that vTR is expressed in vivo in peripheral blood leukocytes from chickens infected with the oncogenic MDV-RB1B and the vaccine MDV-Rispens strains. The functionality of the vTR gene and the potential implication of vTR in the oncogenesis induced by MDV is discussed.

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