scholarly journals Manila grass (Zoysia matrella) Zoy m 1 allergen may contribute to allergic sensitization in tropical/subtropical regions due to extensive cross-reactivity with other group-1 grass pollen allergens

2021 ◽  
Keyword(s):  
Grass Pollen ◽  
Allergic Sensitization ◽  
Cross Reactivity ◽  
Pollen Allergens ◽  
Zoysia Matrella ◽  
Group 1

Functional immunoglobulin E cross-reactivity between Pas n 1 of Bahia grass pollen and other group 1 grass pollen allergens

2011 ◽  
Vol 41 (2) ◽  
pp. 281-291 ◽  
Author(s):  
J. M. Davies ◽  
T. D. Dang ◽  
A. Voskamp ◽  
A. C. Drew ◽  
M. Biondo ◽  
...  
Keyword(s):  
Grass Pollen ◽  
Immunoglobulin E ◽  
Cross Reactivity ◽  
Pollen Allergens ◽  
Bahia Grass ◽  
Group 1

Molecular variability of group 1 and 5 grass pollen allergens between Pooideae species: implications for immunotherapy

2010 ◽  
Vol 40 (3) ◽  
pp. 505-519 ◽  
Author(s):  
H. Chabre ◽  
B. Gouyon ◽  
A. Huet ◽  
V. Boran-Bodo ◽  
E. Nony ◽  
...  
Keyword(s):  
Grass Pollen ◽  
Pollen Allergens ◽  
Molecular Variability ◽  
Group 1

Cross-reactivity between Acacia (wattle) and rye grass pollen allergens

1982 ◽  
Vol 12 (3) ◽  
pp. 259-268 ◽  
Author(s):  
B. J. HOWLETT ◽  
D. J. HILL ◽  
R. B. KNOX
Keyword(s):  
Grass Pollen ◽  
Cross Reactivity ◽  
Pollen Allergens ◽  
Rye Grass

scholarly journals Group-1 Grass Pollen Allergens with Near-Identical Sequences Identified in Species of Subtropical Grasses Commonly Found in Southeast Asia

Medicina ◽  
2019 ◽  
Vol 55 (5) ◽  
pp. 193 ◽  
Author(s):  
Sirirat Aud-in ◽  
Koravit Somkid ◽  
Wisuwat Songnuan
Keyword(s):  
Southeast Asia ◽  
Grass Pollen ◽  
Three Dimensional ◽  
Amino Acid Sequences ◽  
Dimensional Structure ◽  
Grass Species ◽  
Pollen Allergens ◽  
Allergenic Protein ◽  
The Relationship ◽  
Group 1

Background and objectives: Group-1 grass allergens or beta-expansins (EXPBs) are major allergens from pollen of all grass species. Previous studies showed that they are highly conserved (64–85%) in Pooideae species, which are found mostly in the temperate regions. However, the information about group-1 allergens from common grass species in subtropical areas is still lacking. This study aimed to assess the sequence diversity of group-1 grass pollen allergens in subtropical areas, especially in Southeast Asia. Materials and Methods: Group-1 allergens were cloned from pollen of eight grass species using a single set of primers. Sequences were analyzed and IgE and IgG4 binding regions were compared to the previously reported epitopes in homologous EXPBs. The phylogenetic analysis was used to assess the relationship between sequences of these species and previously characterized EXPBs. Moreover, three-dimensional structure of the EXPB was modeled based on homology to Zea m 1. Results: Sequences from eight grass species were nearly identical. It is conceivable that the primers used for cDNA amplification detected the same isoform in different species. In fact, the deduced amino acid sequences shared 97.79–100% identity with each other and 15/819 polymorphic nucleotide positions were identified. The predicted structure showed that the IgE and IgG4 epitopes and polymorphic residues were located in both domains 1 and 2. The dendrogram presents clustering of class A EXPBs into four groups corresponding to the grass subfamilies. Conclusions: This study identified the allergens with near-identical sequences from different grass species. This isoform could be the major cross-reacting allergenic protein from commonly found grass species.

Molecular-Docking-Based Anti-Allergic Drug Design

2016 ◽  
pp. 232-248
Author(s):  
Anamika Basu ◽  
Piyali Basak ◽  
Anasua Sarkar
Keyword(s):  
Molecular Docking ◽  
Rna Interference ◽  
Grass Pollen ◽  
Pollen Allergen ◽  
Allergic Reactions ◽  
Hypersensitivity Reactions ◽  
Pollen Allergens ◽  
Rna Molecules ◽  
Post Transcriptional Gene Silencing ◽  
Group 1

Allergens are foreign proteins that when come in contact of part(s) of human body stimulate the production of immunoglobulin types of proteins (antibodies). These allergens react with antibodies (immunoglobulin type E or IgE) produces allergic reactions, also known as immediate-type hypersensitivity reactions. As much as 20% of the general population may be affected by grass pollen as a major cause of allergic disease. EXPB class of proteins are known in the immunological literature as group-1 grass pollen allergens Molecular docking method can be used to identify the predicated the interaction of pollen allergen EXPB1 (Zea m 1), a beta-expansin and group-1 pollen allergen from maize with IgE molecules of human. The World Health Organization recognised allergen immunotherapy, as therapeutics for allergic diseases. RNA Interference (RNAi) is a biological process in which RNA molecules e.g. Small Interfering RNAs (siRNAs) inhibit gene expression, by cleavage and destruction of specific mRNA molecules. Use of Small Interfering RNA (siRNA) is a novel method in the induction of RNA Interference (RNAi), which is a potent method for therapeutics of allergic reactions. Due to various effects of STAT 6 proteins during hypersensitivity reactions caused by pollen allergens, mRNA of STAT6 gene is selected as target gene for allergy therapeutics via Post-Transcriptional Gene Silencing (PTGS). Using molecular docking study a specific sense siRNA is identified as anti allergic drug to treat allergic asthma during immediate type of hypersensitivity reaction, caused by Zea m 1 pollen allergen.

scholarly journals Molecular-Docking-Based Anti-Allergic Drug Design

2017 ◽  
pp. 711-726
Author(s):  
Anamika Basu ◽  
Piyali Basak ◽  
Anasua Sarkar
Keyword(s):  
Molecular Docking ◽  
Rna Interference ◽  
Grass Pollen ◽  
Pollen Allergen ◽  
Allergic Reactions ◽  
Hypersensitivity Reactions ◽  
Pollen Allergens ◽  
Rna Molecules ◽  
Post Transcriptional Gene Silencing ◽  
Group 1

Allergens are foreign proteins that when come in contact of part(s) of human body stimulate the production of immunoglobulin types of proteins (antibodies). These allergens react with antibodies (immunoglobulin type E or IgE) produces allergic reactions, also known as immediate-type hypersensitivity reactions. As much as 20% of the general population may be affected by grass pollen as a major cause of allergic disease. EXPB class of proteins are known in the immunological literature as group-1 grass pollen allergens Molecular docking method can be used to identify the predicated the interaction of pollen allergen EXPB1 (Zea m 1), a beta-expansin and group-1 pollen allergen from maize with IgE molecules of human. The World Health Organization recognised allergen immunotherapy, as therapeutics for allergic diseases. RNA Interference (RNAi) is a biological process in which RNA molecules e.g. Small Interfering RNAs (siRNAs) inhibit gene expression, by cleavage and destruction of specific mRNA molecules. Use of Small Interfering RNA (siRNA) is a novel method in the induction of RNA Interference (RNAi), which is a potent method for therapeutics of allergic reactions. Due to various effects of STAT 6 proteins during hypersensitivity reactions caused by pollen allergens, mRNA of STAT6 gene is selected as target gene for allergy therapeutics via Post-Transcriptional Gene Silencing (PTGS). Using molecular docking study a specific sense siRNA is identified as anti allergic drug to treat allergic asthma during immediate type of hypersensitivity reaction, caused by Zea m 1 pollen allergen.

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