1B31 Development of microporous covered stent for a treatment of cerebral aneurysm : aneurysmal embolization performance evaluation at curvature parent vessel-saccular aneurysm model

2015 ◽  
Vol 2015.27 (0) ◽  
pp. 73-74
Author(s):  
Takeshi MORIWAKI ◽  
Yasuhide NAKAYAMA ◽  
Ryo HIDAKA ◽  
Tetsu SATO ◽  
Eika HAMANO ◽  
...  
Keyword(s):  
Performance Evaluation ◽  
Cerebral Aneurysm ◽  
Covered Stent ◽  
Saccular Aneurysm ◽  
Parent Vessel ◽  
Aneurysm Model

Cerebral Aneurysm Hemodynamics and a Length of Parent Vessel

2009 ◽  
pp. 1608-1611
Author(s):  
J. Poethke ◽  
A. Spuler ◽  
Ch. Petz ◽  
H. -Ch. Hege ◽  
L. Goubergrits ◽  
...  
Keyword(s):  
Cerebral Aneurysm ◽  
Parent Vessel

Simplified experimental cerebral aneurysm model in rats: Comprehensive evaluation of induced aneurysms and arterial changes in the circle of Willis

2009 ◽  
Vol 1300 ◽  
pp. 159-168 ◽  
Author(s):  
Hany Eldawoody ◽  
Hiroaki Shimizu ◽  
Naoto Kimura ◽  
Atsushi Saito ◽  
Toshio Nakayama ◽  
...  
Keyword(s):  
Cerebral Aneurysm ◽  
Comprehensive Evaluation ◽  
Circle Of Willis ◽  
Aneurysm Model

Treatment of a canine carotid artery aneurysm model with a biodegradable nanofiber-covered stent: A prospective pilot study

2013 ◽  
Vol 61 (3) ◽  
pp. 282 ◽  
Author(s):  
Yong-Dong Li ◽  
Jian-Bo Wang ◽  
Bin Zhou ◽  
Xiu-Ling Gu ◽  
Ming-Hua Li ◽  
...  
Keyword(s):  
Pilot Study ◽  
Carotid Artery ◽  
Artery Aneurysm ◽  
Covered Stent ◽  
Prospective Pilot Study ◽  
Carotid Artery Aneurysm ◽  
Aneurysm Model

scholarly journals In Vitro Study of Near-Wall Flow in a Cerebral Aneurysm Model with and without Coils

2010 ◽  
Vol 31 (8) ◽  
pp. 1521-1528 ◽  
Author(s):  
L. Goubergrits ◽  
B. Thamsen ◽  
A. Berthe ◽  
J. Poethke ◽  
U. Kertzscher ◽  
...  
Keyword(s):  
Cerebral Aneurysm ◽  
In Vitro Study ◽  
Vitro Study ◽  
Wall Flow ◽  
Aneurysm Model ◽  
Near Wall

scholarly journals Genetic correlates of wall shear stress in a patient-specific 3D-printed cerebral aneurysm model

2019 ◽  
Vol 11 (10) ◽  
pp. 999-1003 ◽  
Author(s):  
Michael R Levitt ◽  
Christian Mandrycky ◽  
Ashley Abel ◽  
Cory M Kelly ◽  
Samuel Levy ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Shear Stress ◽  
Wall Shear Stress ◽  
Cerebral Aneurysm ◽  
Cell Morphology ◽  
Patient Specific ◽  
Parent Vessel ◽  
3D Printed ◽  
Wall Shear ◽  
Dynamics Simulations

ObjectivesTo study the correlation between wall shear stress and endothelial cell expression in a patient-specific, three-dimensional (3D)-printed model of a cerebral aneurysm.Materials and methodsA 3D-printed model of a cerebral aneurysm was created from a patient’s angiogram. After populating the model with human endothelial cells, it was exposed to media under flow for 24 hours. Endothelial cell morphology was characterized in five regions of the 3D-printed model using confocal microscopy. Endothelial cells were then harvested from distinct regions of the 3D-printed model for mRNA collection and gene analysis via quantitative polymerase chain reaction (qPCR.) Cell morphology and mRNA measurement were correlated with computational fluid dynamics simulations.ResultsThe model was successfully populated with endothelial cells, which survived under flow for 24 hours. Endothelial morphology showed alignment with flow in the proximal and distal parent vessel and aneurysm neck, but disorganization in the aneurysm dome. Genetic analysis of endothelial mRNA expression in the aneurysm dome and distal parent vessel was compared with the proximal parent vessels. ADAMTS-1 and NOS3 were downregulated in the aneurysm dome, while GJA4 was upregulated in the distal parent vessel. Disorganized morphology and decreased ADAMTS-1 and NOS3 expression correlated with areas of substantially lower wall shear stress and wall shear stress gradient in computational fluid dynamics simulations.ConclusionsCreating 3D-printed models of patient-specific cerebral aneurysms populated with human endothelial cells is feasible. Analysis of these cells after exposure to flow demonstrates differences in both cell morphology and genetic expression, which correlate with areas of differential hemodynamic stress.

scholarly journals A Cerebral Aneurysm Model for Clipping Training

2020 ◽  
Vol 48 (3) ◽  
pp. 161-167
Author(s):  
Hiroshi TENJIN ◽  
Osamu SAITO ◽  
Tsutomu TOKUYAMA ◽  
Toru KAWAKATSU ◽  
Yoshio OKANO
Keyword(s):  
Cerebral Aneurysm ◽  
Aneurysm Model
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