Efficacy of artificial liver support system in severe immune-associated hepatitis caused by camrelizumab: A case report and review of the literature

Objective. An artificial liver support system (ALSS) is an effective therapy for patients with severe liver injury. A vasovagal reaction (VVR) is a common complication in various treatment settings but has not been reported previously in ALSS. Methods. This study retrospectively evaluated patients who suffered an ALSS-related VRR between January 2018 and June 2019. We collected data from VVR episodes including onset time, duration, changes in heart rate (HR) and blood pressure (BP), and drug treatment. Results. Among 637 patients who underwent ALSS treatment, 18 were included in the study. The incidence of VVR was approximately 2.82%. These patients were characterized by a rapid decrease in BP or HR with associated symptoms such as chest distress, nausea, and vomiting. The majority of patients (78%) suffered a VVR during their first ALSS treatment. Sixteen patients (89%) had associated symptoms after treatment began. Sixteen patients (89%) received human albumin or Ringer’s solution. Atropine was used in 11 patients (61%). The symptoms were relieved within 20 min in 15 patients and over 20 min in 3 patients. Conclusions. A VVR is a rare complication in patients with severe liver injury undergoing ALSS treatment. Low BP and HR are the main characteristics of a VVR.

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Biological and artificial liver support system in children: A new perspective*

Pediatric Critical Care Medicine ◽

10.1097/01.pcc.0000170609.49863.03 ◽

2005 ◽

Vol 6 (5) ◽

pp. 616-617 ◽

Cited By ~ 3

Author(s):

George Mazariegos ◽

Yun Chen ◽

Robert Squires

Keyword(s):

Support System ◽

Artificial Liver ◽

Liver Support ◽

Artificial Liver Support ◽

Liver Support System ◽

Artificial Liver Support System ◽

New Perspective

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Efficacy of a Larger Version of the Hybrid Artificial Liver Support System Using a Polyurethane Foam/Spheroid Packed-Bed Module in a Warm Ischemic Liver Failure Pig Model for Preclinical Experiments

Cell Transplantation ◽

10.3727/000000003108746687 ◽

2003 ◽

Vol 12 (2) ◽

pp. 101-107 ◽

Cited By ~ 17

Author(s):

Yo-Ichi Yamashita ◽

Mitsuo Shimada ◽

Eiji Tsujita ◽

Ken Shirabe ◽

Hiroyuki Ijima ◽

...

Keyword(s):

Liver Failure ◽

Polyurethane Foam ◽

Support System ◽

Packed Bed ◽

Artificial Liver ◽

Liver Support ◽

Artificial Liver Support ◽

Liver Support System ◽

Artificial Liver Support System ◽

Group Serum

We have reported the usefulness of a polyurethane foam packed-bed culture system of hepatocyte spheroids as a hybrid artificial liver support system (PUF-HALSS). The aim of this study was to evaluate in detail the efficacy in serum parameters regarding the liver function of a larger version of the PUF-HALSS containing 2 × 1010 porcine hepatocytes for clinical use in warm ischemic liver failure pigs. Warm ischemic liver failure pigs weighing 25 kg were divided into two groups: (1) a control group (n = 3), in which each pig was attached to a PUF-HALSS without hepatocytes, and (2) a HALSS group (n = 3), in which each pig was attached to a PUF-HALSS. In the HALSS group, the increase of blood ammonia was completely suppressed and blood lactate levels were significantly suppressed. The Fisher's ratio was better maintained, and the increase of total bile acid, glycochenodeoxycholic acid, and taurochenodeoxycholic acid was significantly suppressed in the HALSS group. Serum creatinine levels were significantly lower, and blood glucose levels were significantly higher in the HALSS group. Serum levels of tumor necrosis factor- a were not elevated in either group. In conclusion, the larger version of the PUF-HALSS demonstrated many advantages as a liver support system in warm ischemic liver failure pigs.

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