The Secret Life of Waste: Recycling Dreams of Migration

This essay opens up a new perspective on migration through the lens of waste, tracing the effects of war, border securitization, and global capitalism on a local scale. The analysis of Afganistanbul (2018), a short documentary produced by a team at Kadir Has University in Istanbul where the book in hand originated, captures the predicament of undocumented waste workers in the city who lack the means to continue their journey to Europe or return to their homeland, while resources and revenue in the global recycling business circulate freely. Following the film in its close-up on a specific site of life and labour, this essay teases out competing aspirations among local and migrant city dwellers, arguing that representations of migrant experiences are prone to the temptation of poverty porn and calling on spectators to consider their own implication in interlocking systems of inequity.

Functionality, Emotion, and Acceptance of Artificial Intelligence Virtual Assistants

This paper aims to expand the acceptance of the AI Virtual Assistant model from the perspective of user’s cognition. Based on the 240 samples, we used multi-layer regression analysis to investigate the influencing factors and differential effects of users' acceptance of AI Virtual Assistant. The results show that functional cognition and emotional cognition of users are important influencing factors for an artificial intelligence virtual assistant. This provides a new perspective for user acceptance processes of the AI Virtual Assistant. We also examined the moderating effect of social norms between user cognition and AI Virtual Assistant. At last, a new AI acceptance model of AI Virtual Assistant was established.

miR-129 Promotes the Proliferation of Alzheimer’s Neuronal Cells by Binding the 3′ Untranslated Regions (3′ UTR) of Amyloid Precursor Protein (APP)

Alzheimer’s disease (AD) is a neurodegenerative disease with memory loss and cognitive impairment. Short non-coding RNAs (miRNAs) are potential biomarkers and therapeutic targets for AD. This study aims to investigate miR-129’s role in AD. miR-129 and amyloid precursor protein (APP) expression was measured by Q-PCR, and LC3, p62, ATG5, Bcl-2, p-Tau and Caspase3 protein was detected by Western blot. Hydrogenase kits and DCFH-DA detected cell apoptosis, cytotoxicity and ROS generation. The interaction between APP and miR-129 was assessed by luciferase report experiment. HE staining and TUNEL assay evaluated hippocampal neuron damage. In AD patient serum, AD transgenic (TG) mouse brain tissue, and AB1-42-treated SH-SY5Y cells, miR-129 was downregulated but autophagy was increased. Overexpression of miR-129 reduced cell damage induced by AB1-42, and miR-129 can directly regulate APP expression by binding APP 3′-UTR. miR-129 inhibitors reversed the protective effect of shAPP on AB1-42-induced cell damage. In addition, miR-129 overexpression reduced neuronal damage through inhibiting autophagy in vivo. APP expression in AD patient and AD cell model was significantly increased compared to controls. Aβ-42 treatment caused up-regulation of APP expression, while APP knockdown inhibited neurons through autophagy. In conclusion, miR-129 overexpression can regulate autophagy by targeting APP5, thereby reducing neuronal damage in AD. These findings provide a new perspective for treating AD.

Farmers’ Strategies to Climate Change and Urbanization: Potential of Ecosystem-Based Adaptation in Rural Chengdu, Southwest China

Ecosystem-based adaptation (EbA) is emerging as a cost-effective approach for helping people adapt to climate and non-climate changes. Nowadays, climate change and urbanization have affected agricultural systems, but it is not clear how rural communities have responded or adapted to those changes. Here, we chose two typical villages in the Chengdu Plain, southwest China, through sociological surveys on 90 local farmers with a semi-structured questionnaire, participatory observation, geospatial analysis of land use and land cover, and a literature review, to explore the local people’s perception of changes or disturbances and their adaptation strategies from the perspective of EbA. The results showed that climate change and urbanization had impacted agricultural systems dramatically in the last 40 years. In two case-study sites, climate change and urbanization were perceived by most local farmers as the main drivers impacting on agricultural production, but various resource-use models containing abundant traditional knowledge or practices as well as modern tools, such as information communication technology (ICT), were applied to adapt to these changes. Moreover, culture service through the adaptive decoration of rural landscapes is becoming a new perspective for implementing an EbA strategy. Finally, our findings highlighted the potential value of an EbA strategy for sustaining urban-rural integrated development and enhancing the resilience of agricultural systems.

InterTADs: integration of multi-omics data on topologically associated domains, application to chronic lymphocytic leukemia

ABSTRACT The integration of multi-omics data can greatly facilitate the advancement of research in Life Sciences by highlighting new interactions. However, there is currently no widespread procedure for meaningful multi-omics data integration. Here, we present a robust framework, called InterTADs, for integrating multi-omics data derived from the same sample, and considering the chromatin configuration of the genome, i.e. the topologically associating domains (TADs). Following the integration process, statistical analysis highlights the differences between the groups of interest (normal versus cancer cells) relating to (i) independent and (ii) integrated events through TADs. Finally, enrichment analysis using KEGG database, Gene Ontology and transcription factor binding sites and visualization approaches are available. We applied InterTADs to multi-omics datasets from 135 patients with chronic lymphocytic leukemia (CLL) and found that the integration through TADs resulted in a dramatic reduction of heterogeneity compared to individual events. Significant differences for individual events and on TADs level were identified between patients differing in the somatic hypermutation status of the clonotypic immunoglobulin genes, the core biological stratifier in CLL, attesting to the biomedical relevance of InterTADs. In conclusion, our approach suggests a new perspective towards analyzing multi-omics data, by offering reasonable execution time, biological benchmarking and potentially contributing to pattern discovery through TADs.

Antisense agents against antibiotic-resistant bacteria

The dramatically increasing levels of antibiotic resistance are being seen worldwide, and is a significant threat to public health. Antibiotic and drug resistance is seen in various bacterial species. Antibiotic resistance is associated with increased morbidity and mortality and increased treatment costs. Antisense-relevant technologies include the utilization of oligonucleotide molecules to interfere with gene expression, as a new technique for the treatment of antibiotic-resistant bacteria has been proposed antisense agents or nucleic acids analogs with antibacterial properties, which are commonly very short and their size almost 10-20 bases and can be hinted to peptide nucleic acids (PNAs), phosphorodiamidate morpholino oligomers (PPMOs) and locked nucleic acids (LNAs). This review highlights that PNAs, PPMOs, and LNAs target the genes that cause destroy the gene and inhibit the growth of bacteria. These results open a new perspective for therapeutic intervention. In future studies, it is necessary to examine different aspects of antisense agents, for example, safety, toxicity, and pharmacokinetic properties of antisense agents to be employed in clinical treatment.

Electrophysiological Biomarkers for the Assessment of Motor Efficiency in Sport

Many disciplines have approached the study of human motor behavior. The motor learning theory based on information processing proposes a learning loop through interaction between the external environment and the central nervous system. Different neuroscience fields and technological advances provide a new perspective for the intensive study of the intrinsic processes of motor behavior, which modify the most visible aspect: motor efficiency. The aim of the present review was to determine which cortical and muscular electrophysiological biomarkers available in the literature could be representative for the study and quantification of motor efficiency. In this review, a survey of the literature related to motor production has been performed. The continuous development of biological signal monitoring techniques has allowed to understand part of the communication methods of the central nervous system, the integration of neural networks, and the interaction between different anatomic structures through rhythmic patterns of discharge known as brain waves. Motor production has been characterized by detecting electrophysiological biomarkers, taking into account the connectivity that can be represented by the corticomuscular and intermuscular coherence indices in different frequency bands. The present work proposes an approach to use these biomarkers on beta-band (for muscle stability synergies) and gamma-band (for mobility synergies). These indices will allow establishing quantitative parameters for motor efficiency, which could improve the precision of sports assessment.

New Insight into the Coupled Grain–Disaster–Economy System Based on a Multilayer Network: An Empirical Study in China

Natural disasters occur frequently causing huge economic losses and reduced grain production. Therefore, it is important to thoroughly explore the spatial correlations between grain, disaster, and the economy. Based on inter-provincial panel data in China in 2019, this study integrates complex network and co-occurrence theory into a coupled grain–disaster–economy (GDE) multilayer network, which provides a new perspective to further explore the spatial correlation between these three systems. We identify the spatial coupled characteristics of the GDE multilayer network using three aspects: degree, centrality, and community detection. The research results show the following: (1) Provinces in the major grain-producing regions have a stronger role in allocating and controlling grain resources, and the correlation between grain and disasters in these provinces is stronger and more prone to disasters. Whereas provinces in the Beijing–Tianjin–Hebei economic zone, and the Yangtze River Delta and Pearl River Delta economic zones, such as Beijing, Tianjin, Jiangsu, Shanghai, and Zhejiang, have a high level of economic development, thereby a stronger ability to allocate economic resources. (2) The economic subsystem assumes a more important, central role compared with the grain and disaster subsystems in the formation and development of the coupled GDE multilayer network, with a stronger coordination for the co-development between the complex grain, disaster, and economy systems in the nodal provinces of the network. (3) The community modularity of the coupled GDE multilayer network is significantly higher than that of the three single-layer networks, indicating a more reasonable community division after coupling the three subsystems. The identification of the spatial characteristics of GDE using multilayer network analysis offers a new perspective on taking various measures to improve the joint sustainable development of grain, disaster, and the economy in different regions of China according to local conditions.