scholarly journals Macular ganglion cell complex injury in different stages of anterior ischemic optic neuropathy

2021 ◽  
Vol 9 (21) ◽  
pp. 5830-5839
Author(s):  
Wei Zhang ◽  
Xin-Quan Sun ◽  
Xiao-Yan Peng
Keyword(s):  
Ganglion Cell ◽  
Optic Neuropathy ◽  
Cell Complex ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ganglion Cell Complex ◽  
Ischemic Optic Neuropathy ◽  
Complex Injury

A case report of ganglion cell complex change in incipient nonarteritic anterior ischemic optic neuropathy

2019 ◽  
Vol 30 (6) ◽  
pp. NP17-NP20
Author(s):  
Jiyeon Kim ◽  
Arvind Gupta
Keyword(s):  
Case Report ◽  
Ganglion Cell ◽  
Optic Neuropathy ◽  
Structural Changes ◽  
Retinal Nerve Fibre Layer ◽  
Cell Complex ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ganglion Cell Complex ◽  
Ischemic Optic Neuropathy ◽  
Limited Information

Background: Incipient nonarteritic anterior ischemic optic neuropathy is a heavily underdiagnosed ophthalmic condition due to its nature of being asymptomatic. Only a handful of cases have been reported and, therefore, limited information is available in respect to it. To date, incipient nonarteritic anterior ischemic optic neuropathy has been viewed as threatened nonarteritic anterior ischemic optic neuropathy, which does not cause any symptoms or structural change to the affected eye. Case presentation: A 68-year-old female was diagnosed with right incipient nonarteritic anterior ischemic optic neuropathy and left classic nonarteritic anterior ischemic optic neuropathy. Despite her right eye remaining asymptomatic, the optical coherence tomography scan of her right macula at her 3-month follow-up appointment showed thinning of retinal nerve fibre layer and ganglion cell complex. Conclusions: To our knowledge, this is the first ever case report describing a thinning of ganglion cell complex in a patient with incipient nonarteritic anterior ischemic optic neuropathy. This suggests that contrary to current belief, incipient nonarteritic anterior ischemic optic neuropathy can result in subclinical structural changes to the affected eye.

Possibilities of OCT Angiography for Diagnosis of Anterior Ischemic Optic Neuropathy: Parameters of the Ganglion Cell Complex, Optic Disc and Peripapillary Retina

2020 ◽  
pp. 25-28
Author(s):  
E.E. Ioyleva ◽  
◽  
A.Y. Safonenko ◽  
N.A. Gavrilova ◽  
E.P. Andrusyakova ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Optic Disc ◽  
Optic Neuropathy ◽  
Cell Complex ◽  
Anterior Ischemic Optic Neuropathy ◽  
Oct Angiography ◽  
Ganglion Cell Complex ◽  
Ischemic Optic Neuropathy ◽  
Correlation Relationship ◽  
Spectral Oct

Purpose. Study the thickness of periapillary retina, ganglion cell complex and optic disc parameters in patients with nonarteritised anterior ischemic optic neuropathy using the spectral OCT angiography. Material and Methods. We examined 17 people (17 eyes) with unilateral non-arteritised anterior ischemic optic neuropathy (no more than 30 days from the appearance of complaints), the average age was 64.1±8.1 years. The control group consisted of 37 volunteers. All the subjects were treated with spectral OCT angiography on RTVue XR Avanti device (Optovue Inc., USA). Results. In patients with non-arteritised anterior ischemic optic neuropathy, compared to the control group, there was a statistically significant increase in the average thickness of periapillary retina nerve fiber layer from 136 to 403 µm, an increase in optic disc area and neuroretinal belt (p < 0.0001) and the absence of cupping (Cup Volume = 0). A decrease in average thickness of ganglion cell complex was found in 8 out of 17 patients, while all patients showed increases in FLV (p=0.008) and GLV (p=0.036). A direct correlation relationship between FLV (r=0.64; p<0.05) and GLV (r=0.51; p<0.05) was found, as well as a moderate negative correlation relationship between uncorrected visual acuity (r=-0.58; p<0,05), moderate direct correlation relationship between average thickness of periapillary retina nerve fiber layer and thickness of ganglion cell complex (r=0.68; p<0,05), and high inverse correlation relationship between FLV (r=-0.77; p<0,05) and GLV (r=-0.76; p<0,05). Conclusion. A comprehensive analysis of thickness of periapillary retina nerve fiber layer and parameters of ganglion cell complex using spectral OCT angiography may allow for a more accurate detection of early retinal structural abnormalities and the timely commencement of conservative therapy to preserve functional parameters. Key words: spectral OCT angiography, anterior ischemic optic neuropathy, ganglion cell complex, optic disc.

Retinal nerve fiber layer and ganglion cell complex thickness as a diagnostic tool in early stage dysthyroid optic neuropathy

2021 ◽  
pp. 112067212110620
Author(s):  
Lihua Luo ◽  
Dongmei Li ◽  
Lixin Gao ◽  
Wei Wang
Keyword(s):  
Ganglion Cell ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Optic Neuropathy ◽  
Cell Complex ◽  
Ganglion Cell Complex ◽  
Fiber Layer ◽  
Dysthyroid Optic Neuropathy ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness

Purpose To compare the diagnostic accuracy of peripapillary retinal nerve fiber layer with macular ganglion cell complex thickness as an auxiliary tool for the early diagnosis of dysthyroid optic neuropathy and help assess the effectiveness of the treatment. Methods In this retrospective case–control study, a total of 58 thyroid-associated opthalmopathy patients and 58 healthy participants were enrolled in the study. Thyroid-associated opthalmopathy patients were divided according to the European Group Graves’ Orbitopathy severity classification. The thicknesses of peripapillary nerve fiber layer and macular ganglion cell complex were measured using optical coherence tomography and their correlation with the severity of the disease as well as the effect of the treatment was investigated. Results No statistically significant differences were found between the mild thyroid-associated opthalmopathy group and the control group in both peripapillary nerve fiber layer and macular ganglion cell complex thickness. In the moderate-to-severe thyroid-associated opthalmopathy group, however, Temporal and Nasal peripapillary nerve fiber layer thicknesses were lower compared to the control group ( p = 0.041, p = 0.012), whereas in the sight-threatening thyroid-associated opthalmopathy group Temporal Inferior, Nasal Superior, and mean (G) peripapillary nerve fiber layer thicknesses were larger ( p = 0.000, p = 0.004, p = 0.000). No significant differences were observed in the macular ganglion cell complex thickness among the different severity groups and the control groups ( p > 0.05). After treatment, the mean peripapillary nerve fiber layer thickness decreased whereas mean macular ganglion cell complex thickness showed no significant change in the sight-threatening group. A correlation was established between exophthalmos, best corrected visual acuity, clinical activity score, disease course, and the mean peripapillary nerve fiber layer thickness. The area under curve analysis indicated that mean peripapillary nerve fiber layer thickness can be used as a powerful diagnostic tool in early stage dysthyroid optic neuropathy in thyroid-associated opthalmopathy patients. Conclusion Our study indicates that peripapillary nerve fiber layer act as an auxiliary tool for the early diagnosis of dysthyroid optic neuropathy and helps assess the effectiveness of the treatment.

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