scholarly journals New methods for high-throughput synthesis

2001 ◽  
Vol 73 (7) ◽  
pp. 1103-1111 ◽  
Author(s):  
Shū Kobayashi ◽  
Ryo Akiyama

New methodologies for library synthesis have been developed. They are based on new carbon­carbon bond-formation reactions in the solid-phase and organic synthesis using polymer-supported catalysts. We have immobilized alkyl glyoxylate equivalents onto resins and prepared novel polymer-supported imines. We have also developed unprecedented polymer-supported catalysts such as microencapsulated scandium trifluoromethanesulfonate [MC Sc(OTf)3], osmium tetroxide (MC OsO4), and palladium triphenylphosphine [MC Pd(PPh3)] for high-throughput synthesis.

2019 ◽  
Vol 23 (6) ◽  
pp. 643-678
Author(s):  
Lalthazuala Rokhum ◽  
Ghanashyam Bez

Recent years have witnessed a fast development of solid phase synthetic pathways, a variety of solid-supported reagent and its applications in diverse synthetic strategies and pharmaceutical applicability’s. Polymer-supported triphenylphosphine is getting a lot of applications owing to the speed and simplicity in the process. Furthermore, ease of recyclability and reuse of polymer-supported triphenylphosphine added its advantages. This review covers a wide range of useful organic transformations which are accomplished using cross-linked polystyrene-supported triphenylphosphine with the aim of giving renewed interest in the field of organic and medicinal-combinatorial chemistry.


ARKIVOC ◽  
2008 ◽  
Vol 2008 (2) ◽  
pp. 287-293 ◽  
Author(s):  
Gui-Yun Fu ◽  
Lei Guo ◽  
Xue-Chun Mao ◽  
Shou-Ri Sheng ◽  
Shi-Yang Fei ◽  
...  

2003 ◽  
Vol 5 (5) ◽  
pp. 549-553 ◽  
Author(s):  
Ken-ichi Fujita ◽  
Shigeru Hashimoto ◽  
Mitsuhiro Kanakubo ◽  
Akihiro Oishi ◽  
Yoichi Taguchi

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