Chronic venous insufficiency of the lower limbs: Suitability of transcutaneous blood gas monitoring as an endpoint to evaluate the outcome of pharmacological treatment with calcium dobesilate

Author(s):  
J. Marinello ◽  
S. Videla
1996 ◽  
Vol 34 (1) ◽  
pp. 163-168
Author(s):  
Lynn K. Bower ◽  
Sherry L. Barnhart ◽  
Peter Betit ◽  
Barbara Hendon ◽  
Joanne Masi-Lynch ◽  
...  

1992 ◽  
Vol 14 (2) ◽  
pp. 75-79 ◽  
Author(s):  
D. Holmgren ◽  
J. Bjure ◽  
I. Engström ◽  
R. Sixt ◽  
G. Sten ◽  
...  

2011 ◽  
Vol 100 (5) ◽  
pp. 676-679 ◽  
Author(s):  
Kenneth L Sandberg ◽  
Hrolfur Brynjarsson ◽  
Ola Hjalmarson

2015 ◽  
Vol 31 (4) ◽  
pp. 264-274 ◽  
Author(s):  
Eberhard Rabe ◽  
Stefania Ballarini ◽  
Lorenz Lehr

Objective To show the superiority of 500 mg calcium dobesilate vs. placebo in reduction of edema of the lower limbs in patients with chronic venous insufficiency, Clinical, Etiological, Anatomical and Pathophysiological classes C3/C4. Methods A total of 351 patients were randomized (n = 174 calcium dobesilate, n = 177 placebo). Active treatment was 500 mg calcium dobesilate, three times daily for 12 weeks, with a 12-week follow-up. Results At the end of treatment, the relative volume change in the most pathological leg was −0.6 ± 4.8% with calcium dobesilate compared to −0.3 ± 3.3% with placebo (p = 0.09). At the end of follow-up, this was −1.01 ± 5.4% for calcium dobesilate vs. −0.08 ± 3.5% for placebo (p = 0.002). Conclusions Calcium dobesilate treatment resulted in no significant volume change in the most pathological leg between baseline and end of treatment. However, the calcium dobesilate group showed a significantly greater volume decrease in the most pathological leg at the end of follow-up. Calcium dobesilate was well-tolerated, with a safety profile consistent with previously published data.


RSC Advances ◽  
2020 ◽  
Vol 10 (60) ◽  
pp. 36386-36395 ◽  
Author(s):  
Ragnar Seton ◽  
Greger Thornell ◽  
Anders Persson

Replacing rigid transcutaneous blood gas monitoring sensors with microstructured silicone patches, makes the proof of concept system developed and evaluated here a viable first step towards truly continuous measurement on premature neonates.


2020 ◽  
Vol 62 (2) ◽  
pp. 169-174
Author(s):  
Masayuki Ochiai ◽  
Hiroaki Kurata ◽  
Hirosuke Inoue ◽  
Masako Ichiyama ◽  
Junko Fujiyoshi ◽  
...  

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